[1]LEY TJ,MILLER C,DING L,et al.Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia[J].The New England Journal of Medicine,2013,368(22):2059-2074.
[2]ZHENG RS,ZHANG SW,SUN KX,et al.Cancer statistics in China,2016[J].Chinese Journal of Oncology,2023,45(3):212-220.
[3]陈万青,单保恩,郑荣寿,等.2003-2007年中国肿瘤登记地区白血病发病与死亡分析[J].肿瘤,2012,32(4):251-255.
CHEN WQ,SHAN BE,ZHENG RS,et al.Analysis of incidence and mortality of leukemia in registration areas of China from 2003 to 2007[J].Tumor,2012,32(4):251-255.
[4]KANTARJIAN H,KADIA T,DINARDO C,et al.Acute myeloid leukemia:Current progress and future directions[J].Blood Cancer Journal,2021,11(2):41.
[5]DINARDO CD,ERBA HP,FREEMAN SD,et al.Acute myeloid leukeamia[J].Lancet,2023,401:2073-2086.
[6]KOPP F,MENDELL JT.Functional classification and experimental dissection of long noncoding RNAs[J].Cell,2018,172(3):393-407.
[7]CRUZ-MIRANDA GM,HIDALGO-MIRANDA A,BARCENAS-LOPEZ DA,et al.Long non-coding RNA and acute leukemia[J].International Journal of Molecular Sciences,2019,20(3)735.
[8]RANIERI R,PIANIGIANI G,SCIABOLACCI S,et al.Current status and future perspectives in targeted therapy of NPM1-mutated AML[J].Leukemia,2022,36(10):2351-2367.
[9]FALINI B,BRUNETTI L,MARTELLI MP.How I diagnose and treat NPM1-mutated AML[J].Blood,2021,137(5):589-599.
[10]HINDLEY A,CATHERWOOD MA,MCMULLIN MF,et al.Significance of NPM1 gene mutations in AML[J].International Journal of Molecular Sciences,2021,22(18):10040.
[11]BRUNETTI L,GUNDRY MC,SORCINI D,et al.Mutant NPM1 maintains the leukemic state through HOX expression[J].Cancer Cell,2018,34(3):499-512.e9.
[12]PAPAIOANNOU D,PETRI A,DOVEY OM,et al.The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia[J].Nature Communications,2019,10(1):5351.
[13]ZHU G,LUO H,FENG Y,et al.HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia[J].Nature Communications,2021,12(1):1956.
[14]LUO H,ZHU G,XU J,et al.HOTTIP lncRNA promotes hematopoietic stem cell self-renewal leading to AML-like disease in mice[J].Cancer Cell,2019,36(6):645-659.e8.
[15]LUO H,ZHU G,ESHELMAN MA,et al.HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia[J].Molecular Cell,2022,82(4):833-851.e11.
[16]JING Y,JIANG X,LEI L,et al.Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3[J].Journal of Experimental & Clinical Cancer Research,2021,40(1):312.
[17]GOURVEST M,DE CLARA E,WU H C,et al.A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA[J].Leukemia,2021,35(10):2784-2798.
[18]MA X,ZHANG W,ZHAO M,et al.Oncogenic role of lncRNA CRNDE in acute promyelocytic leukemia and NPM1-mutant acute myeloid leukemia[J].Cell Death Discovery,2020,6(1):121.
[19]ETIENNE DE CLARA,MORGANE GOURVEST,MA HJ,et al.Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients[J].Haematologica,2017,102(10):1718-1726.
[20]ZHANG H,ZHAO Y,LIU X,et al.A novel upregulated lncRNA-AC026150.8 promotes chemo-resistance and predicts poor prognosis in acute myeloid leukemia[J].Cancer Medicine,2021,10(23):8614-8629.
[21]XIA PH,XU ZJ,JIN Y,et al.Clinical significance of low expression of lncRNA CASC15 in acute myeloid leukemia with NPM1 mutations[J].Journal of Experimental Hematology,2022,30(3):659-670.
[22]TARLOCK K,LAMBLE AJ,WANG YC,et al.CEBPA-bZip mutations are associated with favorable prognosis in de novo AML:a report from the Children's Oncology Group[J].Blood,2021,138(13):1137-1147.
[23]HUGHES JM,SALVATORI B,GIORGI FM,et al.CEBPA-regulated lncRNAs,new players in the study of acute myeloid leukemia[J].Journal of Hematology & Oncology,2014,7:69.
[24]PAPAIOANNOU D,NICOLET D,VOLINIA S,et al.Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia[J].Haematologica,2017,102(8):1391-1400.
[25]HUGHES JM,LEGNINI I,SALVATORI B,et al.C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia[J].Oncotarget,2015,6(21):18534-18544.
[26]SUN MD,ZHENG YQ,WANG LP,et al.Long noncoding RNA UCA1 promotes cell proliferation,migration and invasion of human leukemia cells via sponging miR-126[J].European Review for Medical and Pharmacological Sciences,2018,22(8):2233-2245.
[27]NITIKA,WEI J,HUI AM.Role of biomarkers in FLT3 AML[J].Cancers,2022,14(5):1164.
[28]REBECHI MT,PRATZ KW.Genomic instability is a principle pathologic feature of FLT3 ITD kinase activity in acute myeloid leukemia leading to clonal evolution and disease progression[J].Leukemia & Lymphoma,2017,58(9):1-11.
[29]YU P,LAN H,SONG X,et al.High expression of the SH3TC2-DT/SH3TC2 gene pair associated with FLT3 mutation and poor survival in acute myeloid leukemia:An integrated TCGA analysis[J].Frontiers in Oncology,2020,10:829.
[30]JIANG X,CHENG Y,HU C,et al.MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5[J].Leukemia & Lymphoma,2019,60(7):1709-1720.
[31]ZHANG R,HUO CH.Long noncoding RNA SOCS2-AS promotes leukemogenesis in FLT3-ITD+acute myeloid leukemia through miRNA-221[J].Onco Targets and Therapy,2020,13:2925-2934.
[32]NGUYEN LXT,ZHANG B,HOANG DH,et al.Cytoplasmic DROSHA and non-canonical mechanisms of miR-155 biogenesis in FLT3-ITD acute myeloid leukemia[J].Leukemia,2021,35(8):2285-2298.
[33]CAI Z,AGUILERA F,RAMDAS B,et al.Targeting Bim via a lncRNA Morrbid regulates the survival of preleukemic and leukemic cells[J].Cell Reports,2020,31(12):107816.
[34]LI JJ,ZHU JF,ZHANG F,et al.Upregulation of lncRNA CCAT2 predicts poor prognosis in patients with acute myeloid leukemia and is correlated with leukemic cell proliferation[J].International Journal of Clinical and Experimental Pathology,2018,11(12):5658-5666.
[35]ZHANG TJ,ZHOU JD,ZHANG W,et al.H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia[J].Clinical Epigenetics,2018,10:47.
[36]OLOFSEN PA,TOUW IP.RUNX1 mutations in the leukemic progression of severe congenital neutropenia[J].Molecules and Cells,2020,43(2):139-144.
[37]NI ZF,MA LJ,SHI LL,et al.Clinical characteristics of acute myeloid leukemia patients with RUNX1 gene mutation[J].Journal of Experimental Hematology,2021,29(5):1411-1416.
[38]GAIDZIK VI,TELEANU V,PAPAEMMANUIL E,et al.RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features[J].Leukemia,2016,30(11):2160-2168.
[39]史超君,苏雁华,高玉娟,等.核心结合因子相关性急性髓系白血病的临床特征、基因突变情况及治疗研究进展[J].现代肿瘤医学,2023,31(9):1769-1774.
SHI CJ,SU YH,GAO YJ,et al.Clinical characteristics,gene mutation and treatment of core binding factor-acute myeloid leukemia[J].Modern Oncology,2023,31(9):1769-1774.
[40]WANG YH,LIN CC,HSU CL,et al.Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125[J].Annals of Hematology,2021,100(2):487-498.
[41]LIU S,XING Y,LU W,et al.RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of p57[J].Haematologica,2019,104(8):1597-1607.
[42]WANG H,LI W,GUO R,et al.An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies[J].International Journal of Cancer,2014,135(12):2783-2794.
[43]TRINH B Q,UMMARINO S,ZHANG Y,et al.Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML[J].Blood,2021,138(15):1331-1344.
[44]FERNANDO TR,CONTRERAS JR,ZAMPINI M,et al.The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia[J].Molecular Cancer,2017,16(1):126.
[45]BRUNETTI L,GUNDRY MC,GOODELL MA.DNMT3A in leukemia[J].Cold Spring Harbor Perspectives in Medicine,2017,7(2):a030320.
[46]DAI YJ,HU F,HE SY,et al.Epigenetic landscape analysis of lncRNAs in acute myeloid leukemia with DNMT3A mutations[J].Annals of Translational Medicine,2020,8(6):318.
[47]DUAN MY,LI M,TIAN H,et al.Down-regulation of lncRNA NEAT1 regulated by miR-194-5p/DNMT3A facilitates acute myeloid leukemia[J].Blood Cells,Molecules & Diseases,2020,82:102417.
[48]ZHANG YY,HUANG SH,ZHOU HR,et al.Role of HOTAIR in the diagnosis and prognosis of acute leukemia[J].Oncology Reports,2016,36(6):3113-3122.
[49]WEISSMANN S,ALPERMANN T,GROSSMANN V,et al.Landscape of TET2 mutations in acute myeloid leukemia[J].Leukemia,2012,26(5):934-942.
[50]YANG F,ANEKPURITANANG T,PRESSR D.Clinical utility of next-generation sequencing in acute myeloid leukemia[J].Molecular Diagnosis & Therapy,2020,24(1):1-13.
[51]CAI Z,KOTZIN JJ,RAMDAS B,et al.Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis[J].Cell Stem Cell,2018,23(6):833-849.e5.
[52]CAI Z,LU X,ZHANG C,et al.Hyperglycemia cooperates with Tet2 heterozygosity to induceleukemia driven by proinflammatory cytokine-induced lncRNA Morrbid[J].The Journal of Clinical Investigation,2021,131(1):e140702.
[53]CHEN L,FAN X,ZHU J,et al.LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia[J].RNA Biology,2020,17(6):784-793.
[54]YAO H,DUAN M,LIN L,et al.TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population[J].Oncotarget,2017,8(11):18337-18347.
[55]PAN JQ,ZHANG YQ,WANG JH,et al.LncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia[J].International Journal of Molecular Medicine,2017,39(3):663-671.
[56]MER A S,LINDBERG J,NILSSON C,et al.Expression levels of long non-coding RNAs are prognostic for AML outcome[J].Journal of Hematology & Oncology,2018,11(1):52.
[57]XIE J,CHEN K,HAN H,et al.Establishment of tumor protein p53 mutation-based prognostic signatures for acute myeloid leukemia[J].Current Research in Translational Medicine,2022,70(4):103347.
[58]DING W,LING Y,SHI Y,et al.DesA prognostic risk model of lncRNAs in patients with acute myeloid leukaemia based on TCGA data[J].Frontiers in Bioengineering and Biotechnology,2022,10:818905.
[59]XU Q,GUO T.Somatic mutation-associated risk index based on lncRNA expression for predicting prognosis in acute myeloid leukemia[J].Hematology(Amsterdam,Netherlands),2022,27(1):659-671.