|Table of Contents|

Research progress on the relationship between long non-coding RNA and common gene mutations in acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 01
Page:
181-188
Research Field:
Publishing date:

Info

Title:
Research progress on the relationship between long non-coding RNA and common gene mutations in acute myeloid leukemia
Author(s):
SHEN YiyangLIU YusiLIU XuanFU ShuangZHANG Jihong
Hematology Laboratory,Shengjing Hospital,China Medical University,Liaoning Shenyang 110022,China.
Keywords:
long non-coding RNAacute myeloid leukemiagene mutation
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2024.01.035
Abstract:
As emerging molecules,long non-coding RNAs(lncRNAs) have attracted much attention in pathogenesis,prognosis and drug resistance of acute myeloid leukemia(AML) in recent years.As an important indicator for prognosis and treatment target of AML,gene mutation has been extensively studied.This review is to summarizes the latest reports of lncRNA researches,and to sort out the relationship between lncRNAs and common mutations in AML,as well as the effects of both on the occurrence and development of AML,therefor to provide reference and ideas for clinical diagnosis and treatment of AML.

References:

[1]LEY TJ,MILLER C,DING L,et al.Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia[J].The New England Journal of Medicine,2013,368(22):2059-2074.
[2]ZHENG RS,ZHANG SW,SUN KX,et al.Cancer statistics in China,2016[J].Chinese Journal of Oncology,2023,45(3):212-220.
[3]陈万青,单保恩,郑荣寿,等.2003-2007年中国肿瘤登记地区白血病发病与死亡分析[J].肿瘤,2012,32(4):251-255. CHEN WQ,SHAN BE,ZHENG RS,et al.Analysis of incidence and mortality of leukemia in registration areas of China from 2003 to 2007[J].Tumor,2012,32(4):251-255.
[4]KANTARJIAN H,KADIA T,DINARDO C,et al.Acute myeloid leukemia:Current progress and future directions[J].Blood Cancer Journal,2021,11(2):41.
[5]DINARDO CD,ERBA HP,FREEMAN SD,et al.Acute myeloid leukeamia[J].Lancet,2023,401:2073-2086.
[6]KOPP F,MENDELL JT.Functional classification and experimental dissection of long noncoding RNAs[J].Cell,2018,172(3):393-407.
[7]CRUZ-MIRANDA GM,HIDALGO-MIRANDA A,BARCENAS-LOPEZ DA,et al.Long non-coding RNA and acute leukemia[J].International Journal of Molecular Sciences,2019,20(3)735.
[8]RANIERI R,PIANIGIANI G,SCIABOLACCI S,et al.Current status and future perspectives in targeted therapy of NPM1-mutated AML[J].Leukemia,2022,36(10):2351-2367.
[9]FALINI B,BRUNETTI L,MARTELLI MP.How I diagnose and treat NPM1-mutated AML[J].Blood,2021,137(5):589-599.
[10]HINDLEY A,CATHERWOOD MA,MCMULLIN MF,et al.Significance of NPM1 gene mutations in AML[J].International Journal of Molecular Sciences,2021,22(18):10040.
[11]BRUNETTI L,GUNDRY MC,SORCINI D,et al.Mutant NPM1 maintains the leukemic state through HOX expression[J].Cancer Cell,2018,34(3):499-512.e9.
[12]PAPAIOANNOU D,PETRI A,DOVEY OM,et al.The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia[J].Nature Communications,2019,10(1):5351.
[13]ZHU G,LUO H,FENG Y,et al.HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia[J].Nature Communications,2021,12(1):1956.
[14]LUO H,ZHU G,XU J,et al.HOTTIP lncRNA promotes hematopoietic stem cell self-renewal leading to AML-like disease in mice[J].Cancer Cell,2019,36(6):645-659.e8.
[15]LUO H,ZHU G,ESHELMAN MA,et al.HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia[J].Molecular Cell,2022,82(4):833-851.e11.
[16]JING Y,JIANG X,LEI L,et al.Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3[J].Journal of Experimental & Clinical Cancer Research,2021,40(1):312.
[17]GOURVEST M,DE CLARA E,WU H C,et al.A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA[J].Leukemia,2021,35(10):2784-2798.
[18]MA X,ZHANG W,ZHAO M,et al.Oncogenic role of lncRNA CRNDE in acute promyelocytic leukemia and NPM1-mutant acute myeloid leukemia[J].Cell Death Discovery,2020,6(1):121.
[19]ETIENNE DE CLARA,MORGANE GOURVEST,MA HJ,et al.Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients[J].Haematologica,2017,102(10):1718-1726.
[20]ZHANG H,ZHAO Y,LIU X,et al.A novel upregulated lncRNA-AC026150.8 promotes chemo-resistance and predicts poor prognosis in acute myeloid leukemia[J].Cancer Medicine,2021,10(23):8614-8629.
[21]XIA PH,XU ZJ,JIN Y,et al.Clinical significance of low expression of lncRNA CASC15 in acute myeloid leukemia with NPM1 mutations[J].Journal of Experimental Hematology,2022,30(3):659-670.
[22]TARLOCK K,LAMBLE AJ,WANG YC,et al.CEBPA-bZip mutations are associated with favorable prognosis in de novo AML:a report from the Children's Oncology Group[J].Blood,2021,138(13):1137-1147.
[23]HUGHES JM,SALVATORI B,GIORGI FM,et al.CEBPA-regulated lncRNAs,new players in the study of acute myeloid leukemia[J].Journal of Hematology & Oncology,2014,7:69.
[24]PAPAIOANNOU D,NICOLET D,VOLINIA S,et al.Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia[J].Haematologica,2017,102(8):1391-1400.
[25]HUGHES JM,LEGNINI I,SALVATORI B,et al.C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia[J].Oncotarget,2015,6(21):18534-18544.
[26]SUN MD,ZHENG YQ,WANG LP,et al.Long noncoding RNA UCA1 promotes cell proliferation,migration and invasion of human leukemia cells via sponging miR-126[J].European Review for Medical and Pharmacological Sciences,2018,22(8):2233-2245.
[27]NITIKA,WEI J,HUI AM.Role of biomarkers in FLT3 AML[J].Cancers,2022,14(5):1164.
[28]REBECHI MT,PRATZ KW.Genomic instability is a principle pathologic feature of FLT3 ITD kinase activity in acute myeloid leukemia leading to clonal evolution and disease progression[J].Leukemia & Lymphoma,2017,58(9):1-11.
[29]YU P,LAN H,SONG X,et al.High expression of the SH3TC2-DT/SH3TC2 gene pair associated with FLT3 mutation and poor survival in acute myeloid leukemia:An integrated TCGA analysis[J].Frontiers in Oncology,2020,10:829.
[30]JIANG X,CHENG Y,HU C,et al.MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5[J].Leukemia & Lymphoma,2019,60(7):1709-1720.
[31]ZHANG R,HUO CH.Long noncoding RNA SOCS2-AS promotes leukemogenesis in FLT3-ITD+acute myeloid leukemia through miRNA-221[J].Onco Targets and Therapy,2020,13:2925-2934.
[32]NGUYEN LXT,ZHANG B,HOANG DH,et al.Cytoplasmic DROSHA and non-canonical mechanisms of miR-155 biogenesis in FLT3-ITD acute myeloid leukemia[J].Leukemia,2021,35(8):2285-2298.
[33]CAI Z,AGUILERA F,RAMDAS B,et al.Targeting Bim via a lncRNA Morrbid regulates the survival of preleukemic and leukemic cells[J].Cell Reports,2020,31(12):107816.
[34]LI JJ,ZHU JF,ZHANG F,et al.Upregulation of lncRNA CCAT2 predicts poor prognosis in patients with acute myeloid leukemia and is correlated with leukemic cell proliferation[J].International Journal of Clinical and Experimental Pathology,2018,11(12):5658-5666.
[35]ZHANG TJ,ZHOU JD,ZHANG W,et al.H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia[J].Clinical Epigenetics,2018,10:47.
[36]OLOFSEN PA,TOUW IP.RUNX1 mutations in the leukemic progression of severe congenital neutropenia[J].Molecules and Cells,2020,43(2):139-144.
[37]NI ZF,MA LJ,SHI LL,et al.Clinical characteristics of acute myeloid leukemia patients with RUNX1 gene mutation[J].Journal of Experimental Hematology,2021,29(5):1411-1416.
[38]GAIDZIK VI,TELEANU V,PAPAEMMANUIL E,et al.RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features[J].Leukemia,2016,30(11):2160-2168.
[39]史超君,苏雁华,高玉娟,等.核心结合因子相关性急性髓系白血病的临床特征、基因突变情况及治疗研究进展[J].现代肿瘤医学,2023,31(9):1769-1774. SHI CJ,SU YH,GAO YJ,et al.Clinical characteristics,gene mutation and treatment of core binding factor-acute myeloid leukemia[J].Modern Oncology,2023,31(9):1769-1774.
[40]WANG YH,LIN CC,HSU CL,et al.Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125[J].Annals of Hematology,2021,100(2):487-498.
[41]LIU S,XING Y,LU W,et al.RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of p57[J].Haematologica,2019,104(8):1597-1607.
[42]WANG H,LI W,GUO R,et al.An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies[J].International Journal of Cancer,2014,135(12):2783-2794.
[43]TRINH B Q,UMMARINO S,ZHANG Y,et al.Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML[J].Blood,2021,138(15):1331-1344.
[44]FERNANDO TR,CONTRERAS JR,ZAMPINI M,et al.The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia[J].Molecular Cancer,2017,16(1):126.
[45]BRUNETTI L,GUNDRY MC,GOODELL MA.DNMT3A in leukemia[J].Cold Spring Harbor Perspectives in Medicine,2017,7(2):a030320.
[46]DAI YJ,HU F,HE SY,et al.Epigenetic landscape analysis of lncRNAs in acute myeloid leukemia with DNMT3A mutations[J].Annals of Translational Medicine,2020,8(6):318.
[47]DUAN MY,LI M,TIAN H,et al.Down-regulation of lncRNA NEAT1 regulated by miR-194-5p/DNMT3A facilitates acute myeloid leukemia[J].Blood Cells,Molecules & Diseases,2020,82:102417.
[48]ZHANG YY,HUANG SH,ZHOU HR,et al.Role of HOTAIR in the diagnosis and prognosis of acute leukemia[J].Oncology Reports,2016,36(6):3113-3122.
[49]WEISSMANN S,ALPERMANN T,GROSSMANN V,et al.Landscape of TET2 mutations in acute myeloid leukemia[J].Leukemia,2012,26(5):934-942.
[50]YANG F,ANEKPURITANANG T,PRESSR D.Clinical utility of next-generation sequencing in acute myeloid leukemia[J].Molecular Diagnosis & Therapy,2020,24(1):1-13.
[51]CAI Z,KOTZIN JJ,RAMDAS B,et al.Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis[J].Cell Stem Cell,2018,23(6):833-849.e5.
[52]CAI Z,LU X,ZHANG C,et al.Hyperglycemia cooperates with Tet2 heterozygosity to induceleukemia driven by proinflammatory cytokine-induced lncRNA Morrbid[J].The Journal of Clinical Investigation,2021,131(1):e140702.
[53]CHEN L,FAN X,ZHU J,et al.LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia[J].RNA Biology,2020,17(6):784-793.
[54]YAO H,DUAN M,LIN L,et al.TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population[J].Oncotarget,2017,8(11):18337-18347.
[55]PAN JQ,ZHANG YQ,WANG JH,et al.LncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia[J].International Journal of Molecular Medicine,2017,39(3):663-671.
[56]MER A S,LINDBERG J,NILSSON C,et al.Expression levels of long non-coding RNAs are prognostic for AML outcome[J].Journal of Hematology & Oncology,2018,11(1):52.
[57]XIE J,CHEN K,HAN H,et al.Establishment of tumor protein p53 mutation-based prognostic signatures for acute myeloid leukemia[J].Current Research in Translational Medicine,2022,70(4):103347.
[58]DING W,LING Y,SHI Y,et al.DesA prognostic risk model of lncRNAs in patients with acute myeloid leukaemia based on TCGA data[J].Frontiers in Bioengineering and Biotechnology,2022,10:818905.
[59]XU Q,GUO T.Somatic mutation-associated risk index based on lncRNA expression for predicting prognosis in acute myeloid leukemia[J].Hematology(Amsterdam,Netherlands),2022,27(1):659-671.

Memo

Memo:
National Natural Science Foundation of China(No.82070165);国家自然科学基金(编号:82070165)
Last Update: 2023-11-30