|Table of Contents|

Research progress on molecular mechanism of EMT in drug resistance of hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 01
Page:
172-177
Research Field:
Publishing date:

Info

Title:
Research progress on molecular mechanism of EMT in drug resistance of hepatocellular carcinoma
Author(s):
ZHANG Yanji1SUI Hong1WANG Kaibing2
1.The Second Department of Internal Medicine,the Affiliated Cancer Hospital of Harbin Medical University,Heilongjiang Harbin 150081,China;2.Hepatobiliary and Pancreatic Interventional Center,the First Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang Hangzhou 310006,China.
Keywords:
EMTchemotherapytarget therapydrug resistance
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2024.01.033
Abstract:
The high heterogeneity of hepatocellular tumor tissue makes hepatocellular carcinoma patients often resistant to chemotherapeutic and targeted drugs.Studies have shown that transcription factors,cytokines and related signaling pathways and some non-coding RNAs that regulate EMT during epithelial-mesenchymal transition mediate the drug resistance of hepatocellular carcinoma.In addition,hepatocytes undergoing EMT displayed characteristics similar to those of cancer stem cells—primary drug resistance.EMT plays an important role in the development of drug resistance in hepatocellular carcinoma.Therefore,we reviewed the role of EMT in the drug resistance mechanism of hepatocellular carcinoma and the feasibility of targeting EMT in the treatment of hepatocellular carcinoma.

References:

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Memo

Memo:
吴阶平医学基金会临床科研专项基金(编号:320.6750.2020-12-7,320.6750.18555);哈尔滨医科大学附属肿瘤医院海燕科研基金项目(编号:JJZD2019-08)
Last Update: 2023-11-30