«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 01

Page:

163-167

Research Field:

Publishing date:

Info

Title:

Research progress on the pathogenesis of radiation induced heart disease

Author(s):

YAO Jie; ZHANG Zhiren

Department of Cardiovascular Medicine,Affiliated Cancer Hospital of Harbin Medical University,Heilongjiang Cancer and Heart Disease Diagnosis and Treatment Center,Heilongjiang Harbin 150081,China.

Keywords:

tumor; radiotherapy; radiation induced heart disease

PACS:

R73

DOI:

10.3969/j.issn.1672-4992.2024.01.031

Abstract:

With the rapid development of radiotherapy technology,malignant tumors have been effectively controlled,but in the process of radiation near the heart,it often leads to different degrees of radiation-induced heart damage,resulting in a series of clinical and pathological changes,namely RIHD.The pathogenesis of RIHD is complex and not yet completely clear,so it is of great significance for clinicians and patients to further explore the pathogenesis of RIHD and put forward effective treatment and prevention.This article focuses on a brief review of the research progress in the pathogenesis of radiation heart disease in recent years.

References:

£Û1£ÝKOUTROUMPAKIS E,PALASKAS NL,LIN SH,et al.Modern radiotherapy and risk of cardiotoxicity£ÛJ£Ý.Chemotherapy,2020,65(3-4):65-76.
£Û2£ÝKIRRESH A,WHITE L,MITCHELL A,et al.Radiation-induced coronary artery disease: a difficult clinical conundrum£ÛJ£Ý.Clin Med(Lond),2022,22(3):251-256.
£Û3£ÝWEI T,CHENG Y.The cardiac toxicity of radiotherapy-a review of characteristics,mechanisms,diagnosis,and prevention£ÛJ£Ý.Int J Radiat Biol,2021,97(10):1333-1340.
£Û4£ÝRAGHUNATHAN D,KHILJI MI,HASSAN SA,et al.Radiation-induced cardiovascular disease£ÛJ£Ý.Curr Atheroscler Rep,2017,19(5):22.
£Û5£ÝVALLERIO P,MALOBERTI A,PALAZZINI M,et al.Thoracic radiotherapy as a risk factor for heart ischemia in subjects treated with chest irradiation and chemotherapy and without classic cardiovascular risk factors£ÛJ£Ý.Radiother Oncol,2020,152:146-150.
£Û6£ÝL¦VPEZ-FERN¦€NDEZ TERESA,LYON AR,JOERG H.2022 Esc guidelines on cardio-oncology:How can we improve the cardiovascular health of patients with cancer and cancer survivors£ÛJ£Ý.European Heart Journal-Cardiovascular Pharmacotherapy,2022,9(1):4-5.
£Û7£ÝCARO-CODON J,JIMENEZ-VALERO S,GALEOTE G,et al.Radiation-induced coronary artery disease:Useful insights from OCT£ÛJ£Ý.Int J Cardiol,2016,202:535-536.
£Û8£ÝIMBALZANO E,TRAPANI G,CREAZZO M,et al.Coronary artery disease in radiotherapy£ÛJ£Ý.Int J Cardiol,2013,168(4):e125-e126.
£Û9£ÝCUOMO JR,JAVAHERI SP,SHARMA GK,et al.How to prevent and manage radiation-induced coronary arterydisease£ÛJ£Ý.Heart,2018,104(20):1647-1653.
£Û10£ÝVOJTISEK R.Cardiac toxicity of lung cancer radiotherapy£ÛJ£Ý.Rep Pract Oncol Radiother,2020,25(1):13-19.
£Û11£ÝZHUANG XF,YANG YM,SUN XL,et al.Late onset radiation-induced constrictive pericarditis and cardiomyopathy after radiotherapy:A case report£ÛJ£Ý.Medicine(Baltimore),2017,96(5):e5932.
£Û12£ÝQUINTERO-MARTINEZ JA,CORDOVA-MADERA SN,VILLARRAGA HR.Radiation-Induced heart disease£ÛJ£Ý.Journal of Clinical Medicine,2021,11(1):20-21.
£Û13£ÝMARINKO T.Pericardial disease after breast cancer radiotherapy£ÛJ£Ý.Radiol Oncol,2018,53(1):1-5.
£Û14£ÝMA CX,ZHAO XK,LI YD.New therapeutic insights into radiation-induced myocardial fibrosis£ÛJ£Ý.Ther Adv Chronic Dis,2019,10:1753160159.
£Û15£ÝPANPAN T,YUCHEN D,XIANYONG S,et al.Cardiac remodelling following cancer therapy:A review£ÛJ£ÝCardiovasc Toxicol,2022,22(9):771-786.
£Û16£ÝCUOMO JR,SHARMA GK,CONGER PD,et al.Novel concepts in radiation-induced cardiovascular disease£ÛJ£Ý.World J Cardiol,2016,8(9):504-519.
£Û17£ÝDONNELLAN E,PHELAN D,MCCARTHY CP,et al.Radiation-induced heart disease:A practical guide to diagnosis and management£ÛJ£Ý.Cleve Clin J Med,2016,83(12):914-922.
£Û18£ÝMADANR,BENSON R,SHARMA DN,et al.Radiation induced heart disease:Pathogenesis,management and review literature£ÛJ£Ý.J Egypt Natl Canc Inst,2015,27(4):187-193.
£Û19£ÝDESAI MY,JELLIS CL,KOTECHA R,et al.Radiation-associated cardiac disease:A practical approach to diagnosis and management£ÛJ£Ý.JACC Cardiovasc Imaging,2018,11(8):1132-1149.
£Û20£ÝADAMS MJ,LIPSITZ SR,COLAN SD,et al.Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapy£ÛJ£Ý.J Clin Oncol,2004,22(15):3139-3148.
£Û21£ÝVAN NIMWEGEN FA,SCHAAPVELD M,CUTTER DJ,et al.Radiation dose-response relationship for risk of coronary heart disease in survivors of hodgkin lymphoma£ÛJ£Ý.J Clin Oncol,2016,34(3):235-243.
£Û22£ÝKIM L,LOCCOH EC,SANCHEZ R,et al.Contemporary understandings of cardiovascular disease after cancer radiotherapy:A focus on ischemic heart disease£ÛJ£Ý.Curr Cardiol Rep,2020,22(11):151.
£Û23£ÝLIN SH,HOBBS BP,VERMA V,et al.Randomized phase ¢òb trial of proton beam therapy versus intensity-modulated radiation therapy for locally advanced esophageal cancer£ÛJ£Ý.J Clin Oncol,2020,38(14):1569-1579.
£Û24£ÝWENNSTIG AK,GARMO H,WADSTEN L,et al.Risk of coronary stenosis after adjuvant radiotherapy for breast cancer£ÛJ£Ý.Strahlenther Onkol,2022,198(7):630-638.
£Û25£ÝCHEN CH,HSIEH CC,CHANG CS,et al.A Retrospective analysis of dose distribution and toxicity in patients with left breast cancer treated with adjuvant intensity-modulated radiotherapy: Comparison with three-dimensional conformal radiotherapy£ÛJ£Ý.Cancer Manag Res,2020,12:9173-9182.
£Û26£ÝAMIN NP,DESAI N,KIM SM,et al.Cardiac monitoring for thoracic radiation therapy:Survey of practice patterns in the united states£ÛJ£Ý.Am J Clin Oncol,2020,43(4):249-256.
£Û27£ÝBOERMA M,SRIDHARAN V,MAO XW,et al.Effects of ionizing radiation on the heart£ÛJ£Ý.Mutat Res,2016,770(Pt B):319-327.
£Û28£ÝWANG B,WANG H,ZHANG M,et al.Radiation-induced myocardial fibrosis:Mechanisms underlying its pathogenesis and therapeutic strategies£ÛJ£Ý.J Cell Mol Med,2020,24(14):7717-7729.
£Û29£ÝSTEINER I.Pathology of radiation induced heart disease£ÛJ£Ý.Rep Pract Oncol Radiother,2020,25(2):178-181.
£Û30£ÝTAUNK NK,HAFFTY BG,KOSTIS JB,et al.Radiation-induced heart disease:Pathologic abnormalities and putative mechanisms£ÛJ£Ý.Front Oncol,2015,5:39.
£Û31£ÝWANG H,WEI J,ZHENG Q,et al.Radiation-induced heart disease:A review of classification,mechanism and prevention£ÛJ£Ý.Int J Biol Sci,2019,15(10):2128-2138.
£Û32£ÝKIYOHARA H,ISHIZAKI Y,SUZUKI Y,et al.Radiation-induced ICAM-1 expression via TGF-beta1 pathway on human umbilical vein endothelial cells,comparison between X-ray and carbon-ion beam irradiation£ÛJ£Ý.J Radiat Res,2011,52(3):287-292.
£Û33£ÝLEASK A.Potential therapeutic targets for cardiac fibrosis:TGF beta,angiotensin,endothelin,CCN2,and PDGF,partners in fibroblast activation£ÛJ£Ý.Circ Res,2010,106(11):1675-1680.
£Û34£ÝMUN GI,KIM S,CHOI E,et al.Pharmacology of natural radioprotectors£ÛJ£Ý.Arch Pharm Res,2018,41(11):1033-1050.
£Û35£ÝSTARK J.Oxidativestress andatherosclerosis£ÛJ£Ý.Orv Hetil,2015,156(28):1115-1119.
£Û36£ÝWANG KX,YE C,YANG X,et al.New insights into the understanding of mechanisms of radiation-induced heart disease£ÛJ£Ý.Curr Treat Options Oncol,2023,24(1):12-29.
£Û37£ÝRAGHUNATHAN D,KHILJI MI,HASSAN SA,et al.Radiation-Induced cardiovascular disease£ÛJ£Ý.Curr Atheroscler Rep,2017,19(5):22.
£Û38£ÝSLEZAK J,KURA B,BABAL P,et al.Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury£ÛJ£Ý.Can J Physiol Pharmacol,2017,95(10):1190-1203.
£Û39£ÝSHIVAPPA P,BERNHARDT GV.Natural radioprotectors on current and future perspectives:A mini-review£ÛJ£Ý.J Pharm Bioallied Sci,2022,14(2):57-71.
£Û40£ÝMUSA AE,SHABEEB D.Radiation-Induced heart diseases:Protective effects of natural products£ÛJ£Ý.Medicina(Kaunas,Lithuania),2019,55(5):126.
£Û41£ÝGE L,LI C,WANG Z,et al.Suppression of oxidative stress and apoptosis in electrically stimulated neonatal rat cardiomyocytes by resveratrol and underlying mechanisms£ÛJ£Ý.J Cardiovasc Pharmacol,2017,70(6):396-404.
£Û42£ÝYANG R,TAN C,NAJAFI M.Cardiac inflammation and fibrosis following chemo/radiation therapy:Mechanisms and therapeutic agents£ÛJ£Ý.Inflammopharmacology,2022,30(1):73-89.
£Û43£ÝDREYFUSS AD,VELALOPOULOU A,AVGOUSTI H,et al.Preclinical models of radiation-induced cardiac toxicity:Potential mechanisms and biomarkers£ÛJ£Ý.Front Oncol,2022,12:920867.
£Û44£ÝC¦ICILE MORO,JOUAN MG,RAKOTOVAO A,et al.Delayed expression of cytokines after reperfused myocardial infarction:Possible trigger for cardiac dysfunction and ventricular remodeling£ÛJ£Ý.Heart & Circulatory Physiology,2007,62(5):H3014-H3019.
£Û45£ÝBOCK FJ,TAIT S.Mitochondria as multifaceted regulators of cell death£ÛJ£Ý.Nat Rev Mol Cell Biol,2020,21(2):85-100.
£Û46£ÝWANG H,WEI J,ZHENG Q,et al.Radiation-induced heart disease:A review of classification,mechanism and prevention£ÛJ£Ý.Int J Biol Sci,2019,15(10):2128-2138.
£Û47£ÝKURA B,BABAL P,SLEZAK J.Implication of microRNAs in the development and potential treatment of radiation-induced heart disease£ÛJ£Ý.Can J Physiol Pharmacol,2017,95(10):1236-1244.
£Û48£ÝTOMASZEWSKI JM,CROOK S,WAN K,et al.A case study evaluating deep inspiration breath-hold and intensity-modulated radiotherapy to minimise long-term toxicity in a young patient with bulky mediastinal Hodgkin lymphoma£ÛJ£Ý.Journal of Medical Radiation Ences,2017,64(1):69-75.
£Û49£ÝKHAN SU,SAEED S,SHEIKH AN,et al.Crafting a blueprint for microRNA in cardiovascular diseases(CVDs)£ÛJ£Ý.Curr Probl Cardiol,2023,48(12):102010.
£Û50£ÝWANG Y,SCHEIBER MN,NEUMANN C,et al.MicroRNA regulation of ionizing radiation-induced premature senescence£ÛJ£Ý.Int J Radiat Oncol Biol Phys,2011,81(3):839-848.
£Û51£ÝZHU H,FAN GC.Role of microRNAs in the reperfused myocardium towards post-infarct remodelling£ÛJ£Ý.Cardiovasc Res,2012,94(2):284-292.
£Û52£ÝVICZENCZOVA C,KURA B,EGAN BT,et al.Irradiation-induced cardiac connexin-43 and miR-21 responses are hampered by treatment with atorvastatin and aspirin£ÛJ£Ý.International Journal of Molecular Sciences,2018,19(4):1128-1138.
£Û53£ÝKWON OS,KIM KT,LEE E,et al.Induction of miR-21 by stereotactic body radiotherapy contributes to the pulmonary fibrotic response£ÛJ£Ý.PLoS One,2016,11(5):e154942.
£Û54£ÝCHEN Y,CUI J,GONG Y,et al.MicroRNA:A novel implication for damage and protection against ionizing radiation£ÛJ£Ý.Environ Sci Pollut Res Int,2021,28(13):15584-15596.

Memo

Memo:

-

Common functions

Last Update: 2023-11-30