|Table of Contents|

Clinical and pathological analysis of 11 cases of high-grade cervical neuroendocrine carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 01
Page:
130-134
Research Field:
Publishing date:

Info

Title:
Clinical and pathological analysis of 11 cases of high-grade cervical neuroendocrine carcinoma
Author(s):
WU Min1; FU Min2; YUAN Junqing2; ZHU Huiting2; 3; GE Junhui2; LIAO Ling4
1.Department of Pathology,Mingguang People's Hospital,Anhui Chuzhou 239400,China;2.Shanghai AKM Pathology and Diagnostics Co.,Ltd.,Shanghai 200331,China;3.Shanghai First Maternal and Child Health Hospital,Shanghai 201204,China;4.Department of Gynecology,Mingguang People's Hospital,Anhui Chuzhou 239400,China.
Keywords:
cervix; neuroendocrine; clinical pathology
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.01.023
Abstract:
Objective:To investigate the clinicopathological and features,diagnosis and differential diagnosis,treatment,prognosis of primary high-grade neuroendocrine carcinoma of the cervix.Methods:The clinicopathological 11 cases of primary high-grade neuroendocrine carcinoma of the cervix were evaluated by histopathology,immunohistochemistry.Results:The average age of the 11 patients was 59 years old.The tumors of 9 cases of small cell neuroendocrine carcinoma were cauliflower or nodular,diameter in 1.5～4.0 cm.The section was gray yellow and gray red.Microscopically,the tumor cells were small,round or oval cells with consistent size,little cytoplasm,more mitotic images,arranged in flake,beam,island,and some were accompanied by squamous cell carcinoma and adenocarcinoma.2 cases of large cell neuroendocrine carcinoma showed island-like,beam like,adenoid,and solid growth with necrosis,eosinophilic cytoplasmic granules and mitosis.Immunohistochemistry showed Syn,CgA,CD56,p16,CKpan and Ki-67 were mostly positive and CK5/6,p40 and p63 were mostly negative.Conclusion:The high-grade cervical neuroendocrine carcinoma is rare.It is mostly postmenopausal.Major clinical manifestations were irregular colporrhagia.It is easy to be misdiagnosed as poorly differentiated cervical cancer,often complicated with squamous cell carcinoma,adenocarcinoma and necrosis.It needs to be diagnosed by morphology and immunohistochemistry.

References:

［1］WHO Classification of Tumors Editorial Board.World Health Organization classification of the femle genital tumours［M］.5th ed.Lyon:IARC Press,2020:451-459.
［2］LEE SW,LIM KT,BAE DS,et al.A multicenter study of the importance of systemic chemotherapy for patients with small-cell neuroendocrine carcinoma of the uterine cervix［J］.Gynecol Obstet Invest,2015,79(3):172-178.
［3］SALVO G,MARTIN AG,GONZALES NR,et al.Updates and management algorithm for neuroendocrine tumors of the uterine cervix［J］.Int J Gynecol Cancer,2019,29(6):986-995.
［4］LU J,LI Y,WANG J.Small cell(neuroendocrine) carcinoma of the cervix:An analysis for 19 cases and literature review［J］.Front Cell Infect Microbiol,2022,12:916506.
［5］白冰,仓顺东,阚云珍,等.218例神经内分泌肿瘤流行病学及病理学特征分析［J］.现代肿瘤医学,2019,27(13):2391-2394. BAI B,CANG SD,QUE YZ,et al.Epidemiological and pathological characteristics of 218 neuroendocrine tumors［J］.Modern Oncology,2019,27(13):2391-2394.
［6］PRODROMIDOU A,PHELPS DL,PERGIALIOTIS V,et al.Clinicopathological characteristics and survival outcomes of patients with large cell neuroendocrine carcinoma of the uterine cervix:A systematic review and Meta-analysis［J］.Eur J Obstet Gynecol Reprod Biol,2022,270:212-220.
［7］HILLMAN RT,CARDNELL R,FUJIMOTO J,et al.Comparative genomics of high grade neuroendocrine carcinoma of the cervix［J］.PLoS One,2020,15(6):e0234505.
［8］SIRIAUNKGUL S,UTAIPAT U,SUWIWAT S,et al.Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix［J］.Asian Pac J Cancer Prev,2012,13(7):3281-3285.
［9］WHARTON D,KIM E,PAGAN J,et al.Patterns of care and outcomes for small cell carcinoma of the cervix:A national retrospective analysis of 542 cases［J］.Adv Radiat Oncol,2019,5(3):412-418.
［10］GADDUCCI A,CARINELLI S,ALETTI G.Neuroendocrine tumors of the uterine cervix:A therapeutic challenge［J］.Gynecol Oncol,2017,144:637-646.
［11］周庭庆,吴海燕,李国苗.14例宫颈小细胞神经内分泌癌临床病理分析［J］.现代肿瘤医学,2019,27(19):3483-3486. ZHOU TQ,WU HY,LI GM.Clinicopathological analysis of 14 cases of cervical small cell neuroendocrine carcinoma［J］.Modern Oncology,2019,27(19):3483-3486.
［12］YIN ZM,YU AJ,WU MJ,et al.Effects and toxicity of neoadjuvant chemotherapy preoperative followed by adjuvant chemoradiation in small cell neurdendocrine cervical carcinoma［J］.Eur J Gynaecol Oncol,2015,36(3):326-329.
［13］GORDHANDAS S,SCHLAPPE BA,ZHOU Q,et al.Small cell neuroendocrine carcinoma of the cervix:Analysis of prognostic factors and patterns of metastasis［J］.Gynecol Oncol Rep,2022,43:101058.
［14］STOLER MH,MILLS SE,GERSELL DJ,et al.Small-cell neuroendocrine carcinoma of the cervix.A human papillomavirus type 18-associated cancer［J］.Am J Surg Pathol,1991,15(1):28-32.
［15］CONNER MG,RICHTER H,MORAN CA,et al.Small cell carcinoma of the cervix:A clinicopathologic and immunohistochemical study of 23 cases［J］.Ann Diagn Pathol,2002,6(6):345-348.
［16］ABELER VM,HOLM R,NESLAND JM,et al.Small cell carcinoma of the cervix.A clinicopathologic study of 26 patients［J］.Cancer,1994,73(3):672-677.
［17］SMALL WJR,BACON MA,BAJAJ A,et al.Cervical cancer:A global health crisis［J］.Cancer,2017,123(13):2404-2412.
［18］李聪聪，朱莉.宫颈癌的病因及宫颈癌疫苗现状［J］.现代肿瘤医学，2018,26（20）：3333-3336. LI CC,ZHU L.The cause of cervical cancer and the status of cervical cancer vaccine［J］.Modern Oncology,2018,26（20）：3333-3336.
［19］CHAO A,WU RC,LIN CY,et al.Small cell neuroendocrine carcinoma of the cervix:From molecular basis to therapeutic advances［J］.Biomed J，2023,7:100633.
［20］ALEJO M,ALEMANY L,CLAVERO O,et al.RIS HPV TT study group.Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases［J］.Papillomavirus Res,2018,5:134-142.
［21］INZANI F,SANTORO A,ANGELICO G,et al.Neuroendocrine carcinoma of the uterine cervix:A clinicopathologic and immunohistochemical study with focus on novel markers(Sst2-Sst5)［J］.Cancers(Basel),2020,12(5):1211.
［22］陈继明,肖惠超,魏炜炜,等.子宫颈小细胞神经内分泌癌的研究进展［J］.中国肿瘤外科杂志,2018,10(4):260-264. CHEN JM,XIAO HC,WEI WW,et al.Research progress in small cell neuroendocrine carcinoma of the cervix［J］.Chinese Journal of Oncology Surgery,2018,10(4):260-264.
［23］科尔曼，爱伦森，罗奈特.Blaustein女性生殖道病理学［M］.薛德彬译.6版.北京：北京科技出版社,2011：276-279. KURMAN RJ,ELLENSON LH,RONNETT BM.Blaustein female reproductive tract pathology［M］.XUE DB translation.6th edition.Beijing:Beijing Science and Technology Press,2011：276-279.
［24］TEMPFER CB,TISCHOFF I,DOGAN A,et al.Neuroendocrine carcinoma of the cervix:A systematic review of the literature［J］.BMC Cancer,2018,18(1):530.
［25］OKUMURA T,NOGUCHI T,SEKIGUCHI N,et al.Clinical analysis of extrapulmonary neuroendocrine carcinoma:A retrospective and single institution experience［J］.Chemotherapy,2023,68(2):87-94.
［26］HUANG L,LIAO LM,LIU AW,et al.Analysis of the impact of platinum-based combination chemotherapy in small cell cervical carcinoma:A multicenter retrospective study in Chinese patients［J］.BMC Cancer,2014,14:140.
［27］VERMA S,DUBEY H,GUPTA S,et al.Neuroendocrine carcinoma of cervix and review literature［J］.Int J Surg Case Rep,2023,105:107982.
［28］OKABE A,ISHIDA M,NODA Y,et al.Small-cell neuroendocrine carcinoma of the cervix accompanied by adenocarcinoma and high-grade squamous intraepithelial lesion［J］.Diagn Cytopathol,2022,50(10):E285-E288.

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Last Update: 2023-11-30