|Table of Contents|

Expression and correlation of p-STAT3 and STING protein in gastric cancer tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 01
Page:
79-86
Research Field:
Publishing date:

Info

Title:
Expression and correlation of p-STAT3 and STING protein in gastric cancer tissues
Author(s):
YANG Du1TIAN Tongde2ZHANG Chenghui1YUE Wenli3
1.Department of Medical Oncology,Affiliated Nanyang Central Hospital of Zhengzhou University,Henan Nanyang 473000,China;2.Integrated Traditional Chinese and Western Medicine Department,Affiliated Tumor Hospital of Zhengzhou University,Henan Zhengzhou 450000,China;3.Department of Medical Oncology,Affiliated Zhengzhou Central Hospital of Zhengzhou University,Henan Zhengzhou 450000,China.
Keywords:
gastric cancerSTINGp-STAT3
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2024.01.014
Abstract:
Objective:To detect the expression of p-STAT3 and STING protein in gastric cancer tissue and adjacent tissues,and analyze the correlation between p-STAT3 and STING in gastric cancer tissue and the clinicopathological characteristics and prognosis of Hp,stage,lymph node metastasis,and the relationship between them.Methods:Immunohistochemical staining was used to detect the expression of STING,p-STAT3 and Hp infection in cancer tissues and adjacent tissues.Results:The expression of STING in gastric cancer tissue was lower than that in adjacent tissue,while the expression of p-STAT3 in gastric cancer tissue was higher than that in adjacent tissue,with statistical significance.The expression of STING in gastric cancer tissue was positively correlated with the prognosis of gastric cancer patients.The expression level of STING was negatively correlated with staging and lymph node metastasis.It was not related to age,gender,smoking history,or Hp infection.The expression of p-STAT3 in gastric cancer tissue was negatively correlated with the prognosis of gastric cancer patients.p-STAT3 was positively correlated with staging,lymph node metastasis,and Hp infection.There is no correlation between the expression of p-STAT3 and age,gender,and smoking history.There was no correlation between p-STAT3 expression and STING expression in gastric cancer tissue.Conclusion:The expression of STING in gastric cancer tissue is lower than that in adjacent tissues.High expression of STING suggests a better prognosis.The expression of p-STAT3 in gastric cancer tissue is higher than that in adjacent tissues.High expression of p-STAT3 suggests poor prognosis.There is no correlation between the expression of STING and p-STAT3 in gastric cancer tissue.

References:

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Last Update: 2023-11-30