|Table of Contents|

Analysis of factors influencing recurrence of pN0 esophageal squamous cell carcinoma in two years after thoracoabdominal surgery

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 01
Page:
75-79
Research Field:
Publishing date:

Info

Title:
Analysis of factors influencing recurrence of pN0 esophageal squamous cell carcinoma in two years after thoracoabdominal surgery
Author(s):
LI Runxiao; SHEN Wenbin; CAO Yankun; DENG Wenzhao
Department of Radiation Oncology,the Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang 050011,China.
Keywords:
esophageal neoplasms/esophageal squamous cell carcinoma; surgical treatment; factor analysis
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.01.013
Abstract:
Objective:To investigate the factors and characteristics of recurrence of pN0 esophageal squamous cell carcinoma patients within 2 years after operation in chest and abdomen.Methods：A total of 467 patients with esophageal cancer who underwent surgery in our hospital from January 2013 to December 2018 were enrolled.The survival status,influencing factors and recurrence patterns within 2 years were analyzed,and statistical analysis was performed using SPSS 25.0 statistical software.Results：The overall survival rates of the patients in the 1st,3rd,and 5th years were 88.4%,71.9%,and 62.9%,respectively.55 patients relapsed within 2 years,and the overall survival rates of 1,3,and 5 years were significantly lower than those of other patients (χ2=103.258,P=0.000).The recurrence time of patients who relapsed within 2 years was 1.2 to 24.0 months,with a median of 9.0 months.Univariate analysis showed that the rate of recurrence of upper thoracic esophageal cancer patients was 21.3% within 2 years,which was significantly higher than that of patients with middle/lower thorax (χ2=7.045,P=0.030).The higher the degree of intraoperative adhesion,the higher the recurrence rate (χ2=6.653,P=0.036).The later the pT stage,the risk of early recurrence was also significantly increased (χ2=15.975,P=0.001).Multivariate analysis showed that esophageal lesions and T stage were independent factors affecting recurrence within 2 years (P=0.011,0.000).26 cases (47.3%) of simple mediastinal lymph node recurrence were the main recurrence sites in patients with recurrence within 2 years.Conclusion:Patients with pN0 thoracic esophageal squamous cell carcinoma have a high local recurrence rate within 2 years,and the recurrence pattern is mainly recurrence of mediastinal lymph nodes.Pathological T stage and lesion site are independent factors affecting recurrence within 2 years.Clinicians should actively follow-up observation and necessary adjuvant treatment for patients with upper thoracic esophageal cancer and patients with late pT stage.

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Last Update: 2023-11-30