|Table of Contents|

Clinical observation of thoracoscopic and laparoscopic radical esophageal cancer surgery combined with early enteral nutrition support in the treatment of elderly esophageal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 01
Page:
64-68
Research Field:
Publishing date:

Info

Title:
Clinical observation of thoracoscopic and laparoscopic radical esophageal cancer surgery combined with early enteral nutrition support in the treatment of elderly esophageal cancer
Author(s):
LIN JieCHEN MingzhiGAO Pengfei
Yixing People's Hospital,Jiangsu Yixing 214200,China.
Keywords:
laparoscopic radical thoracic surgeryearly enteral nutritional supportesophageal cancernutritional statusanastomotic fistula
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.01.011
Abstract:
Objective:To study the effect of thoracoscopic and laparoscopic radical surgery combined with early enteral nutrition support in the treatment of elderly esophageal cancer.Methods:The study subjects were 96 elderly esophageal cancer patients admitted to our hospital from January 2018 to December 2021.They were randomly divided into an observation group and a control group,with 48 patients in each group.The control group received postoperative parenteral nutrition support treatment,while the observation group received postoperative enteral nutrition support treatment.The postoperative hospitalization time,anal exhaust time,first bowel movement time,time to get out of bed,time to resume diet,as well as nutritional status indicators such as albumin(ALB),total protein(TP),prealbumin(PA),and body mass index(BMI),immune function indicators such as CD3+,CD4+,CD8+,CD4+/CD8+ were compared between the two groups.The occurrence of major complications in both groups was observed.Results:The hospitalization time,anal exhaust time,first bowel movement time,and recovery time of the observation group were all shorter than those of the control group(P<0.05).The ALB,TP,PA and BMI of the observation group were higher than those of the control group 7 days after surgery(P<0.05).The CD3+,CD4+,CD4+/CD8+ levels in the observation group were higher than those in the control group 7 days after surgery(P<0.05).The incidence of anastomotic fistula,pulmonary complications,and total complications in the observation group(P<0.05) was lower than that in the control group.Conclusion:Early enteral nutrition support can effectively improve the nutritional status of elderly patients after thoracoscopic and laparoscopic radical esophageal cancer surgery,enhance immune function,reduce complications,and promote postoperative recovery.It has significant clinical value.

References:

[1]汪永和,岳庆峰,江陈,等.胸腹腔镜联合下食管癌切除术与开放手术的临床疗效对比[J].中国内镜杂志,2022,28(3):23-28. WANG YH,YUE QF,JIANG C,et al.Comparison of clinical efficacy between thoracoscopic laparoscopy combined with esophagectomy and open surgery[J].China Journal of Endoscopy,2022,28(3):23-28.
[2]余嘉文,程进,姚文娟,等.规范化营养干预下食管癌患者放化疗营养状况分析[J].重庆医学,2022,51(11):1841-1845. YU JW,CHENG J,YAO WJ,et al.Analysis of chemoradiotherapeutic nutritional status under standardized nutritional intervention in patients with esophageal cancer [J].Chongqing Medicine,2022,51(11):1841-1845.
[3]JI Y,DU X,ZHU W,et al.Efficacy of concurrent chemoradiotherapy with S-1 vs radiotherapy alone for older patients with esophageal cancer:A multicenter randomized phase 3 clinical trial[J].JAMA Oncol,2021,7(10):1459-1466.
[4]KANG YK,CHEN LT,RYU MH,et al.Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative,untreated,unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer(ATTRACTION-4):a randomised,multicentre,double-blind,placebo-controlled,phase 3 trial[J].Lancet Oncol,2022,23(2):234-247.
[5]MOTOORI M,SUGIMURA K,TANAKA K,et al.Comparison of synbiotics combined with enteral nutrition and prophylactic antibiotics as supportive care in patients with esophageal cancer undergoing neoadjuvant chemotherapy:A multicenter randomized study[J].Clin Nutr,2022,41(5):1112-1121.
[6]KANG J,YANG G,WANG D,et al.The clinical application value of the prognostic nutritional index for the overall survival prognosis of patients with esophageal cancer:A robust real-world observational study in China[J].Comput Math Methods Med,2022,2022:3889588.
[7]张继如,方婷婷,丁怡,等.胸腹腔镜食管癌根治术老年患者术后肺部并发症与术前营养不良的关系[J].中华麻醉学杂志,2022,42(3):260-264. ZHANG JR,FANG TT,DING Y,et al.Relationship between postoperative pulmonary complications and preoperative malnutrition in elderly patients undergoing thoracoscopic and laparoscopic radical esophagectomy[J].Chinese Journal of Anesthesiology,2022,42(3):260-264.
[8]杨丽晖,徐凤娟,靳晓倩,等.SAP患者鼻胃管肠内营养时机选择及肠源性感染指标表达水平的变化分析[J].中国中西医结合急救杂志,2023,30(2):199-203. YANG LH,XU FJ,JIN XQ,et al.Analysis of the enteral nutrition timing in nasogastric tube and the expression level of intestinal infection indexes in severe acute pancreatitis patients[J].Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2023,30(2):199-203.
[9] HU Y,CHEN F,XIANG X,et al.Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia:a randomized controlled trial[J].Ital J Pediatr,2022,48(1):146.
[10]LI XK,CONG ZZ,WU WJ,et al.Enteral immunonutrition versus enteral nutrition for patients undergoing esophagectomy:a randomized controlled trial[J].Ann Palliat Med,2021,10(2):1351-1361.
[11]DRESEN E,WEIBBRICH C,FIMMERS R,et al.Medical high-protein nutrition therapy and loss of muscle mass in adult ICU patients:A randomized controlled trial[J].Clin Nutr,2021,40(4):1562-1570.
[12]裴文晔,于玲,姜桂春.食管癌术后早期肠内营养支持的临床效果[J].中国医科大学学报,2021,50(6):544-547. PEI WY,YU L,JIANG GC.Clinical effects of early enteral nutrition support for patients after esophageal cancer surgery[J].Journal of China Medical University,2021,50(6):544-547.
[13]何建冰,段红兵,康健乐,等.食管癌病人围手术期营养状况对其术后恢复的影响[J].肠外与肠内营养,2021,28(2):75-78. HE JB,DUAN HB,KANG JL,et al.The effect of perioperative nutritional status on postoperative recovery of patients with EC[J].Parenteral & Enteral Nutrition,2021,28(2):75-78.
[14]王玉静,金郁.肠外营养对肝癌手术患者胃肠功能恢复与免疫功能及感染的影响[J].中华医院感染学杂志,2022,32(7):1050-1054. WANG YJ,JIN Y.Effect of parenteral nutrition on gastrointestinal function recovery,immune function and infection in patients undergoing liver cancer surgery[J].Chinese Journal of Nosocomiology,2022,32(7):1050-1054.
[15]吕兰,罗荣刚,杨家英,等.围手术期肺康复对胸腹腔镜联合食管癌根治术后肺部并发症的影响[J].中国康复医学杂志,2022,37(3):343-347. LV L,LUO RG,YANG JY,et al.Effect of perioperative pulmonary rehabilitation on pulmonary complications after thoracic laparoscopy combined with radical resection of esophageal cancer[J].Chinese Journal of Rehabilitation Medicine,2022,37(3):343-347.
[16]FAN JH,SUN WY,YANG H,et al.Short-term and long-term effect of nutrition intervention in the Linxian Dysplasia Nutrition Intervention Trial and the reason for disappearance of the intervention effect:A cohort study[J].Cancer,2023,129(15):2360-2372.
[17]BERKELMANS GHK,FRANSEN LFC,DOLMANS-ZWARTJES ACP,et al.Direct oral feeding following minimally invasive esophagectomy(NUTRIENT II trial):An international,multicenter,open-label randomized controlled trial[J].Ann Surg,2020,271(1):41-47.
[18]QIN L,ZHANG XX,JIN X,et al.The effect of acupuncture on enteral nutrition and gastrointestinal dynamics in patients who have suffered a severe stroke[J].Curr Neurovasc Res,2022,19(3):275-281.

Memo

Memo:
江苏大学2022年度医教协调创新基金(编号:JDY2022016)
Last Update: 2023-11-30