|Table of Contents|

Research advances of SIRT4 in malignancy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 24
Page:
4630-4633
Research Field:
Publishing date:

Info

Title:
Research advances of SIRT4 in malignancy
Author(s):
ZHOU Rang; SHI Qingyu
Department of Bone and Soft Tissue Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150000，China.
Keywords:
SIRT4; malignancy; tumor suppression; tumor promotion; metabolic reprogramming
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.24.029
Abstract:
Malignant tumor is a kind of malignant disease which affects the health of middle-aged and old people,reduces people's quality of life,has an increasing incidence rate year by year,and gradually shows a trend of younger patients.SIRT4 (silent information regulator 2-4) is a NAD+dependent deacylase that is mainly located in mitochondria and can regulate many important biological processes such as stress resistance,maintenance of genomic stability and energy metabolism.In recent years,many reports have suggested that SIRT4 has inhibitory or promotive effects on malignant tumours.In this paper,we summarize and outline the recent studies related to SIRT4 in malignant tumours.

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