|Table of Contents|

Clinical application of infrared fluorescence imaging in parathyroid preservation during radical resection for thyroid cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 24
Page:
4548-4551
Research Field:
Publishing date:

Info

Title:
Clinical application of infrared fluorescence imaging in parathyroid preservation during radical resection for thyroid cancer
Author(s):
WANG Yunsheng1; XUE Jincai1; WANG Xingyue1; DONG Fang2; TIAN Youxin1; LIU Qinjiang1
1.Head and Neck Surgery Department;2.Department of Radiotherapy,Gansu Cancer Hospital,Gansu Lanzhou 730050,China.
Keywords:
thyroid cancer; radical resection; parathyroid gland; infrared fluorescence imaging
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2023.24.011
Abstract:
Objective:To investigate the application value of infrared fluorescence imaging in the identification and protection of parathyroid glands during radical resection of thyroid cancer.Methods:137 patients with thyroid cancers enrolled from January June 2021 to March 2022 in department of head and neck surgery of our hospital were selected as research objects.All patients underwent bilateral radical thyroidectomy combined with bilateral central lymph node dissection and/or lateral neck dissection.The parathyroid gland identified by naked eye and infrared fluorescence imaging,and the detection rate and accuracy rate of the two methods were analyzed.Results:A total of 491 parathyroid glands were found in 137 patients.462(94.1%) parathyroid glands were detected by naked eye and 484(98.6%) parathyroid glands were detected by infrared fluorescence imaging(χ2=13.956,P＜0.01).However,the accuracy was 98.1%(462/471) by naked eye and 97.8%(484/495) by infrared fluorescence imaging(χ2=0.115,P＞0.05).Conclusion:Infrared fluorescence imaging can improve the detection rate of parathyroid gland in radical thyroidectomy,effectively identify and protect the parathyroid gland.

References:

［1］ CHEN DW,LANG BHH,MCLEOD DSA,et al.Thyroid cancer［J］.Lancet,2023,401(10387):1531-1544.
［2］ 赵宁,滕长胜.甲状腺癌手术中甲状旁腺的识别和保护［J］.国际外科学杂志,2015,42(2):105-108. ZHAO N,TENG CS.Identification and protection of parathyroid glands during thyroid cancer surgery［J］.International Journal of Surgery,2015,42(2):105-108.
［3］ 姜敏,赵玉军,高鹏.吲哚菁绿联合纳米炭双示踪技术在腔镜甲状腺乳头状癌手术中的应用［J］.现代肿瘤医学,2022,30(24):4453-4457. JIANG M,ZHAO YJ,GAO P.The application of indocyanine green combined with nano carbon dual tracer technology in endoscopic surgery for papillary thyroid cancer ［J］.Modern Oncology,2022,30(24):4453-4457.
［4］ 王军轶,高明.甲状旁腺术中快速识别技术的进展［J］.中国肿瘤临床,2019,46(9):479-483. WANG JY,GAO M.Progress in rapid identification techniques during parathyroid surgery ［J］.Chinese Clinical Oncology,2019,46 (9):479-483.
［5］ 张进军,夏文飞,沈文状,等.免疫胶体金法甲状旁腺快速鉴定技术及其临床应用价值研究［J］.中国实用外科杂志,2018,38(2):227-230. ZHANG JJ,XIA WF,SHEN WZ,et al.Study on the rapid identification technology of parathyroid glands using immunocolloidal gold method and its clinical application value ［J］.Chinese Journal of Practical Surgery,2018,38(2):227-230.
［6］ PARAS C,KELLER M,WHITE L,et al.Near-infrared auto fluorescence for the detection of parathyroid glands［J］.Biomed Opt,2011,16(6):67012.
［7］ WANG J,YU F,SHANG Y,et al.Thyroid cancer:incidence and mortality trends in China,2005-2015［J］.Endocrine,2020,68(1):163-173.
［8］ HAYMART MR.Progress and challenges in thyroid cancer management［J］.Endocr Pract,2021,27(12):1260-1263.
［9］ HONG K,CEN K,CHEN Q,et al.Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy［J］.Front Immunol,2023,14:1128390.
［10］ VIOLA N,AGATE L,CAPRIO S,et al.Thyroid autoimmunity,thyroglobulin autoantibodies,and thyroid cancer prognosis［J］.Endocr Relat Cancer,2023,30(7):e230042.
［11］ 曾玉剑,钱军,程若川,等.甲状腺癌术中淋巴示踪剂应用对于甲状旁腺保护作用的研究［J］．重庆医学，2012,41(11):1076-1088. ZENG YJ,QIAN J,CHENG RC,et al.A study on the protective effect of intraoperative lymphatic tracers on the parathyroid gland in thyroid cancer ［J］.Chongqing Medical Journal,2012,41 (11):1076-1088.
［12］ BILEZIKIAN JP.Hypoparathyroidism［J］.J Clin Endocrinol Metab，2020，105(6):1722-1736.
［13］ PADURARU DN,ION D,CARSOTE M,et al.Post-thyroidectomy hypocalcemia-risk factors and management［J］.Chirurgia (Bucur),2019,114(5):564-570.
［14］ LUKINOVIC J,BILIC M.Overview of thyroid surgery complications［J］.Acta Clin Croat,2020,59(Suppl 1):81-86.
［15］ FANCY T,GALLAGHER D,HORNIG JD.Surgical anatomy of the thyroid and parathyroid glands［J］.Otolaryngol Clin North Am,2010,43(2):221-227.
［16］ 朱阿考,叶静,张方捷,等.甲状腺癌手术发生甲状旁腺损伤的危险因素分析及处理策略［J］.肿瘤学杂志,2016,22(12):1052-1055. ZHU AKao,YE Jing,ZHANG Fangjie,et al.Analysis of risk factors and management strategies for parathyroid injury in thyroid cancer surgery ［J］.Journal of Oncology,2016,22(12):1052-1055.
［17］ BAJ J,SITARZ R,TOKAJ M,et al.Preoperative and intraoperative methods of parathyroid gland localization and the diagnosis of parathyroid adenomas［J］.Molecules,2020,25(7):1724.
［18］ TIAN W,JIANG Y,GAO B,et al.Application of Nano-Carbon in lymph node dissection for thyroid cancer and protection of parathyroid glands［J］.Medical Science Monitor International Medical Journal of Experimental & Clinical Research,2014,20(24):1925-1930.
［19］ KIM DH,KIM SH,JUNG J,et al.Indocyanine green fluorescence for parathyroid gland identification and function prediction:Systematic review and meta-analysis［J］.Head Neck,2022,44(3):783-791.
［20］ CHRISTOU N,MATHONNET M.Complications after total thyroidectomy［J］.Visc Surg,2013,150(4):249-256.
［21］ MC WADE MA,PARAS C,WHITE LM,et al.Label-free intraoperative parathyroid localization with near-infrared autofluorescence imaging［J］.Clin Endocrinol Metab,2014,99(12):4574-4580.
［22］ 王涛,柳桢,殷德涛,等.近红外荧光下甲状旁腺自体荧光强度潜在影响因素分析及其对术中甲状旁腺识别的指导［J］.中华耳鼻咽喉头颈外科杂志,2020,55(5):490-496. WANG T,LIU Z,YIN DT,et al.Analysis of potential influencing factors on parathyroid autofluorescence intensity under near-infrared fluorescence and its guidance for intraoperative parathyroid gland recognition ［J］.Chinese Journal of Otolaryngology Head and Neck Surgery,2020,55(5):490-496.
［23］ 韦树建,郑桂彬,刘洋,等.甲状旁腺自体荧光在甲状腺癌根治手术中的临床应用［J］.中国耳鼻咽喉头颈外科,2020,27(8):446-450. WEI SJ,ZHENG GB,LIU Y,et al.The clinical application of parathyroid autofluorescence in radical surgery for thyroid cancer ［J］.Chinese Journal of Otolaryngology,Head and Neck Surgery,2020,27(8):446-450.

Memo

Memo:
甘肃省兰州市科技发展计划项目(编号:2022-3-36)
Last Update: 1900-01-01