|Table of Contents|

 Research progress of tumor-associated fibroblasts in tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 22
Page:
4267-4272
Research Field:
Publishing date:

Info

Title:
 Research progress of tumor-associated fibroblasts in tumors
Author(s):
 ZHANG Shijie<sup>1; 2; 3; 4</sup>; JIANG Jinxun<sup>1; 2; 3; 4</sup>; WANG Qiling<sup>1; 2; 3; 4</sup>; WANG Zhen<sup>1; 2; 3; 4</sup>
 
Keywords:
 ; cancer associated fibroblasts; cancer; tumor microenvironment; targeted therapy
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.22.033
Abstract:
 Cancer associated fibroblasts (CAFs) are the main stromal cells in the tumor micro-environment.CAFs can express characteristic biological markers,such as fibroblast activated protein (FAP),α-smooth muscle actin (α-SMA).Research have demonstrated that CAFs can remodel the extracellular matrix,control metabolism,suppress immunological responses,promote angiogenesis,and preserve tumor cell stemness to inhibit apoptosis and promote biological characteristics such tumor growth,invasion,migration,immune escape,and treatment resistance.Therefore,CAFs can be served as the tie or bridge tumors and tumor micro-environment.Taking CAFs as the target to inhibit or block the occurrence or development of tumors,might provide us a new idea for the treatment of tumors in clinics.

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Memo

Memo:
 National Natural Science Foundation of China(No.82002492);国家自然科学基金青年科学基金项目(编号：82002492);广西医科大学第一附属医院“优秀医学英才”科研创新能力培养项目（编号：202207）
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