|Table of Contents|

Research progress of tumor microenvironment in diffuse large B cell lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 22
Page:
4252-4256
Research Field:
Publishing date:

Info

Title:
Research progress of tumor microenvironment in diffuse large B cell lymphoma
Author(s):
SUI JingchenYAN Xiaojing
Department of Hematology,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China.
Keywords:
tumor microenvironment(TME)diffuse large B cell lymphoma(DLBCL)tumor-associated macrophages(TAMs)cancer-associated fibroblasts(CAFs)
PACS:
R730.2
DOI:
10.3969/j.issn.1672-4992.2023.22.030
Abstract:
Tumor microenvironment(TME) plays an important role in the development of tumor.Previously,diffuse large B cell lymphoma (DLBCL) was believed to be caused by malignant cell proliferation,and gene expression profile(GEP) studies showed that tumor microenvironmental components were involved in the development of diffuse large B cell lymphoma.Stromal cells,lymphoma cells and the extracellular matrix componentssecreted by them interact with each other to promote tumor cell proliferation,migration,invasion,drug resistance and immune escape.The impact of TME in DLBCL remains controversial.The effects of TME components on diffuse large B cell lymphoma were summarized in this paper.

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