|Table of Contents|

Association between genetic variants of m6A binding protein IGF2BP2 with the risk of gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 21
Page:
3973-3979
Research Field:
Publishing date:

Info

Title:
Association between genetic variants of m6A binding protein IGF2BP2 with the risk of gastric cancer
Author(s):
LU Xinyuan1; FENG Yanlu1; GE Yiling1; XU Siyi1; LI Jie1; WANG Xinhua2; LIANG Geyu1
1.Key Laboratory of Environmental Medicine Engineering，Ministry of Education，School of Public Health，Southeast University，Jiangsu Nanjing 210009,China;2.Wuwei Tumor Hospital，Gansu Wuwei 733000，China.
Keywords:
m6A; gastric cancer; IGF2BP2; single nucleotide polymorphism
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2023.21.013
Abstract:
Objective:To investigate the association between single nucleotide polymorphisms（SNP) of rs4402960，rs11705701，rs1470579 and rs9877179 with the risk of gastric cancer.Methods:A case-control study was conducted by collecting 548 gastric cancer cases and 706 healthy controls in Wuwei，Gansu Province.The four SNPs were genotyped using the Hi-SNP high-throughput genotyping method.The association between the SNPs with the risk of gastric cancer were analyzed by χ2 test and Logistic regression.Results:The SNP rs9877179 of the IGF2BP2 gene was significantly associated with the significantly reduced risk of gastric cancer(P<0.05).The rs9877179 GG genotype carriers had the significantly reduced risk of gastric cancer compared to TT/TG genotypes carriers.The subgroups analysis revealed that,the G allele carriers had the significantly reduced risk of gastric cancer compared to T allele carriers among female.The GG genotype carriers had the significantly reduced risk of intermediate to advanced gastric cancer compared to the TT/TG genotypes carriers.In addition，no association was found between rs4402960，rs11705701 and rs1470579 with the risk of gastric cancer.Conclusion:The rs9877179 of the IGF2BP2 gene was associated with the risk of gastric cancer，and the GG genotype and G allele may be protective factors for gastric cancer.

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Memo

Memo:
National Natural Science Foundation of China（No.81972998）;国家自然科学基金（编号:81972998）；中央高校基本科研业务费专项基金（编号：2242023k30021）
Last Update: 2023-09-28