|Table of Contents|

Research progress on DNA methylation modification and treatment of gallbladder cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 19
Page:
3678-3683
Research Field:
Publishing date:

Info

Title:
Research progress on DNA methylation modification and treatment of gallbladder cancer
Author(s):
PENG Haiying123LI Lin12LI Tiantian123HU Haiyan123LUO Mengzhen123 CHU Mengyuan123LIAO Liwei12
1.Central Laboratory of Yan'an Hospital Affiliated to Kunming Medical University,Yunnan Kunming 650051,China;2.Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province,Yunnan Kunming 650051,China;3.Kunming Medical University,Yunnan Kunming 650500,China.
Keywords:
gallbladder cancerepigeneticsDNA methylationDNA methylation inhibitors
PACS:
R735.8
DOI:
10.3969/j.issn.1672-4992.2023.19.029
Abstract:
Gallbladder cancer(GBC) is a rare but highly malignant tumor,with difficulty in early diagnosis,poor prognosis and multi-drug resistance,meanwhile,the pathogenesis of this disease has not been clarified yet.The studies on GBC mainly focuses on the search for early diagnosis biomarkers and therapeutic targets.GBC is considered to be atype of tumor with epigenetic abnormalities,in which DNA methylation is one of the most common modifying abnormalities.DNA methylationlevel increases with tumor progression and contributes to the evolution and development of GBC,thus it can serve as a potential biomarker.Furthermore,due to the reversibility of DNA methylation,DNA methylation inhibitors are expected to improve patient prognosis and drug resistance by combining with other drugs.We will discuss the regulation of DNA methylation on GBC,so as to provide someresearch ideas for early diagnosis,prevention and treatment of GBC.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.82260522);国家自然科学基金资助项目(编号:82260522);云南省科技厅昆明医科大学应用基础研究联合专项资金(编号:202001AY070001-168)
Last Update: 2023-08-31