|Table of Contents|

The value of 18F-FDG PET/CT dynamic imaging in the diagnosis of primary liver cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 19
Page:
3653-3657
Research Field:
Publishing date:

Info

Title:
The value of 18F-FDG PET/CT dynamic imaging in the diagnosis of primary liver cancer
Author(s):
XU Yue; LYU Tao; ZHAO Yihan; WANG Xin; YIN Jiankang; WANG Hui; YU Wenjing; ZHU Gan; SI Hongwei
Department of Nuclear Medicine,the First Affiliated Hospital of Anhui Medical University，Anhui Hefei 230022,China.
Keywords:
18F-FDG; whole-body dynamic PET/CT; Patlak; primary liver cancer
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2023.19.023
Abstract:
Objective:To investigate the value of dynamic 18F-FDG PET/CT parameter imaging in the diagnosis of primary liver cancer.Methods:The dynamic PET/CT images and their parameters of 27 patients with hepatocellular carcinoma and 21 patients with intrahepatic cholangiocarinoma confirmed by pathology in our hospital from March 2022 to January 2023 were analyzed retrospectively.The maximum standardized uptake value（SUVmax) and FDG metabolic rate（MRFDG) of primary lesions,average standardized uptake value（SUVmean) and average FDG metabolic rate（MRmean) of non-tumor liver tissue and target background ratio（TBR) were analyzed in patients with primary liver cancer of different pathological types and with or without metastasis.Two independent sample t-tests were used to compare tumor metabolic parameters between two patient groups.The discrimination threshold for TBR to distinguish the two groups of patients was obtained through ROC curve analysis，and the sensitivity and specificity of each group were obtained.Results:The SUVmax,MRFDG,TBRMR and TBRSUV of the primary lesions of intrahepatic cholangiocarinoma were higher than those of hepatocellular carcinoma（P<0.05).The SUVmax and MRFDG of the primary liver lesion in the metastatic group were higher than those in the non-metastatic group(P<0.05).ROC curve analysis found that when TBRSUV≥3.43 or TBRMR≥3.68，the diagnosis of intrahepatic cholangiocarinoma was considered.The sensitivity of TBRSUV was 87%，the specificity was 92%，and the sensitivity of TBRMR was 91%，while the specificity was only 78%.Conclusion:The metabolic parameter MRFDG of dynamic 18F-FDG PET/CT has high value in the diagnosis of different pathological types of primary liver cancer，and has a guiding role in the diagnosis and staging evaluation of primary liver cancer.Its semi-quantitative parameter TBRMR has a higher discriminatory sensitivity than TBRSUV and a higher image contrast in the images of hepatocellular carcinoma patients，helping diagnostic physicians to reduce missed diagnosis.

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Last Update: 2023-08-31