|Table of Contents|

Clinical study of Shidao Tongjie Granules combined with Omeprazole in the treatment of esophageal cancer postoperative reflux esophagitis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 19
Page:
3588-3593
Research Field:
Publishing date:

Info

Title:
Clinical study of Shidao Tongjie Granules combined with Omeprazole in the treatment of esophageal cancer postoperative reflux esophagitis
Author(s):
DONG Yun1; 2; JIN Changjuan1; SHEN Shengping1; CUI Qing1; ZHANG Shi1; YI Kaiyan1; ZHANG Ming1
1.Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine，Shanghai 200030，China;2.Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China.
Keywords:
reflux esophagitis; post-operative esophageal cancer; Shidao Tongjie Granules（S-D-T-J）
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.19.010
Abstract:
Objective:To observe the clinical efficacy of Shidao Tongjie Granules（S-D-T-J） combined with Omeprazole capsules in the treatment of esophageal cancer postoperative reflux esophagitis.Methods:Ninety-eight patients esophageal cancer postoperative with reflux esophagitis were randomly divided into treatment and control groups.50 patients in the treatment group were given S-D-T-J with Omeprazole,and 48 patients in the control group were given control granules with Omeprazole,and the duration of treatment was 8 weeks in both groups.Before treatment and at 4 weeks and 8 weeks after treatment,ratings by reflux diagnostic questionnaire（RDQ）,observation of endoscopic efficacy,the expression levels of serum gastrin（GAS）,gastrin actin（MOT）,interleukin-17（IL-17） and interleukin-23（IL-23） measured by enzyme linked immunosorbent assay(ELSA),assessment of Traditional Chinese Medicine(TCM) symptoms score and Karnofsky(KPS) score were compared.Results:After treatment,there was a significant decrease in the RDQ score in both groups（P<0.05）,but the difference between the groups was not statistically significant.The endoscopic efficacy was 72% in the treatment group and 50% in the control group,and the endoscopic efficacy was significantly better in the treatment group than in the control group（P<0.05）.GAS and MOT were significantly higher in both groups after treatment by ELSA,and the difference was statistically significantd ompare with that before treatment（P<0.05）,and the values of GAS and MOT were significantly higher in the treatment group than in the controlgroup（P<0.05）.IL-17 and IL-23 were significantly lower in both groups after treatment by ELSA,and the difference was statistically significant compared with that before treatment（P<0.05）,and the values of IL-17 and IL-23 were significantly lower in the treatment group than in the control group after treatment（P<0.05）.The efficacy of each symptom,such as panacidity,heartburn,food reflux and retrosternal discomfort,was significantly improved in both groups after treatment（P<0.05）,and the improvement in the treatment group was significantly better than that in the control group（P<0.05）.Secondary symptoms such as abdominal bloating and distension,belching,lack of appetite,and foreign body sensation in the throat were also significantly improved in both groups（P<0.05）.KPS scores improved significantly in both groups（P<0.05）,and patients in the treatment group had significantly higher KPS scores than those in the control group（P<0.05）.Conclusion:S-D-T-J combined with Omeprazole can significantly improve symptoms and improve patients' quality of life in the treatment of postoperative reflux esophagitis in esophageal cancer.And the clinical efficacy is better than that of Omeprazole alone.

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Memo

Memo:
National Natural Science Foundation of China（No.81904114）;国家自然科学青年基金(编号：81904114）
Last Update: 2023-08-31