［1］SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2021,71(3):209-249.
［2］MAOMAO C,HE L,DIANQIN S,et al.Current cancer burden in China:epidemiology,etiology,and prevention［J］.Cancer Biol Med,2022,19(8):1121-1138.
［3］LUO Z,ZHOU X,MANDAL K,et al.Reconstructing the tumor architecture into organoids ［J］.Adv Drug Deliv Rev,2021,176:113839.
［4］MIRABELLI P,MIRABELLI P,COPPOLA L,et al.Cancer cell lines are useful model systems for medical research［J］.Cancers(Basel),2019,11(8)：1098.
［5］CORSINI NS,KNOBLICH JA.Human organoids:New strategies and methods for analyzing human development and disease［J］.Cell,2022,185(15):2756-2769.
［6］LESAVAGE BL,SUHAR RA,BROGUIERE N,et al.Next-generation cancer organoids ［J］.Nat Mater,2022,21(2):143-159.
［7］LAI Y,WEI X,LIN S,et al.Current status and perspectives of patient-derived xenograft models in cancer research［J］.J Hematol Oncol,2017,10(1):106.
［8］WANG E,XIANG K,ZHANG Y,et al.Patient-derived organoids(PDOs) and PDO-derived xenografts(PDOXs):New opportunities in establishing faithful pre-clinical cancer models［J］.Journal of the National Cancer Center,2022,2(4):263-276.
［9］BEN-DAVID U,HA G,TSENG YY,et al.Patient-derived xenografts undergo mouse-specific tumor evolution［J］.Nat Genet,2017,49(11):1567-1575.
［10］COLELLA G,FAZIOLI F,GALLO M,et al.Sarcoma spheroids and organoids-promising tools in the era of personalized medicine［J］.Int J Mol Sci,2018,19(2)：615.
［11］GUNTI S,HOKE ATK,VU KP,et al.Organoid and spheroid tumor models:techniques and applications［J］.Cancers(Basel),2021,13(4)：874.
［12］THAKURI PS,LIU C,LUKER GD,et al.Biomaterials-based approaches to tumor spheroid and organoid modeling［J］.Adv Healthc Mater,2018,7(6):e1700980.
［13］JAGER M,BLOKZIJL F,SASSELLI V,et al.Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures［J］.Nat Protoc,2018,13(1):59-78.
［14］TUVESON D,CLEVERS H.Cancer modeling meets human organoid technology［J］.Science,2019,364(6444):952-955.
［15］MOSCONA A,MOSCONA H.The dissociation and aggregation of cells from organ rudiments of the early chick embryo［J］.J Anat,1952,86(3):287-301.
［16］WEISS P,TAYLOR AC.Reconstitution of complete organs from single-cell suspensions of chick embryos in advanced stages of differentiation［J］.Proc Natl Acad Sci USA,1960,46(9):1177-1185.
［17］RHEINWALD JG,GREEN H.Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma［J］.Cell,1975,6(3):317-330.
［18］LI ML,AGGELER J,FARSON DA,et al.Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells［J］.Proc Natl Acad Sci USA,1987,84(1):136-140.
［19］STREULI CH,SCHMIDHAUSER C,BAILEY N,et al.Laminin mediates tissue-specific gene expression in mammary epithelia［J］.J Cell Biol,1995,129(3):591-603.
［20］SATO T,VRIES RG,SNIPPERT HJ,et al.Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche［J］.Nature,2009,459(7244):262-265.
［21］DALERBA P,KALISKY T,SAHOO D,et al.Single-cell dissection of transcriptional heterogeneity in human colon tumors［J］.Nat Biotechnol,2011,29(12):1120-1127.
［22］DROST J,CLEVERS H.Organoids in cancer research［J］.Nat Rev Cancer,2018,18(7):407-418.
［23］SAITO Y.Establishment of an organoid bank of biliary tract and pancreatic cancers and its application for personalized therapy and future treatment［J］.J Gastroenterol Hepatol,2019,34(11):1906-1910.
［24］HOMAN KA,GUPTA N,KROLL KT,et al.Flow-enhanced vascularization and maturation of kidney organoids in vitro［J］.Nat Methods,2019,16(3):255-262.
［25］LOHMUSSAAR K,KOPPER O,KORVING J,et al.Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids［J］.Nat Commun,2020,11(1):2660.
［26］ROELOFS C,HOLLANDE F,REDVERS R,et al.Breast tumour organoids:promising models for the genomic and functional characterisation of breast cancer［J］.Biochem Soc Trans,2019,47(1):109-117.
［27］YI SA,ZHANG Y,RATHNAM C,et al.Bioengineering approaches for the advanced organoid research［J］.Adv Mater,2021,33(45):e2007949.
［28］BOIX-MONTESINOS P,SORIANO-TERUEL PM,ARMINAN A,et al.The past,present,and future of breast cancer models for nanomedicine development［J］.Adv Drug Deliv Rev,2021,173:306-330.
［29］CLARK CC,YOO KM,SIVAKUMAR H,et al.Immersion bioprinting of hyaluronan and collagen bioink-supported 3D patient-derived brain tumor organoids［J］.Biomed Mater,［2023-03-06］.https://www.researchgate.net/publication/365148747_Immersion_bioprinting_of_hyaluronan_and_collagen_bioink-supported_3D_patient-derived_brain_tumor_organoids.
［30］JIANG S,ZHAO H,ZHANG W,et al.An automated organoid platform with inter-organoid homogeneity and inter-patient heterogeneity［J］.Cell Rep Med,2020,1(9):100161.
［31］KASSIS T,HERNANDEZ-GORDILLO V,LANGER R,et al.Orga quant:human intestinal organoid localization and quantification using deep convolutional neural networks［J］.Sci Rep,2019,9(1):12479.
［32］MATTHEWS JM,SCHUSTER B,KASHAF SS,et al.OrganoID:A versatile deep learning platform for tracking and analysis of single-organoid dynamics［J］.PLoS Comput Biol,2022,18(11):e1010584.
［33］HENKE E,NANDIGAMA R,ERGUN S.Extracellular matrix in the tumor microenvironment and its impact on cancer therapy［J］.Front Mol Biosci,2019,6:160.
［34］FANG G,LU H,RODRIGUEZ DE LA FUENTE L,et al.Mammary tumor organoid culture in non-adhesive alginate for luminal mechanics and high-throughput drug screening［J］.Adv Sci(Weinh),2021,8(21):e2102418.
［35］CAPELING MM,CZERWINSKI M,HUANG S,et al.Nonadhesive alginate hydrogels support growth of pluripotent stem cell-derived intestinal organoids［J］.Stem Cell Reports,2019,12(2):381-394.
［36］CARIGGA GUTIERREZ NM,LE CLAINCHE T,COLL JL,et al.Generating large numbers of pancreatic microtumors on alginate-gelatin hydrogels for quantitative imaging of tumor growth and photodynamic therapy optimization［J］.Methods Mol Biol,2022,2451:91-105.
［37］CRUZ-ACUNA R,GARCIA AJ.Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions［J］.Matrix Biol,2017,57:324-333.
［38］LIANG L,CUI R,ZHONG S,et al.Analysis of the potential role of photocurable hydrogel in patient-derived glioblastoma organoid culture through RNA sequencing［J］.Biomater Sci,2022,10(17):4902-4914.
［39］NG S,TAN WJ,PEK MMX,et al.Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture［J］.Biomaterials,2019,219:119400.
［40］JUNTTILA MR,DE SAUVAGE FJ.Influence of tumour micro-environment heterogeneity on therapeutic response［J］.Nature,2013,501(7467):346-354.
［41］FORSYTHE SD,SIVAKUMAR H,ERALI RA,et al.Patient-specific sarcoma organoids for personalized translational research:unification of the operating room with rare cancer research and clinical implications［J］.Ann Surg Oncol,2022,29(12):7354-7367.
［42］BOCK N,FOROUZ F,HIPWOOD L,et al.GelMA,click-chemistry gelatin and bioprinted polyethylene glycol-based hydrogels as 3D ex vivo drug testing platforms for patient-derived breast cancer organoids［J］.Pharmaceutics,2023,15(1)：261.
［43］COSTARD LS,HOSN RR,RAMANAYAKE H,et al.Influences of the 3D microenvironment on cancer cell behaviour and treatment responsiveness:A recent update on lung,breast and prostate cancer models［J］.Acta Biomater,2021,132:360-378.
［44］CONTESSI NEGRINI N,RICCI C,BONGIORNI F,et al.An osteosarcoma model by 3D printed polyurethane scaffold and in vitro generated bone extracellular matrix［J］.Cancers(Basel),2022,14(8)：2003.
［45］VELASCO V,SHARIATI SA,ESFANDYARPOUR R.Microtechnology-based methods for organoid models［J］.Microsyst Nanoeng,2020,6:76.
［46］BRANDENBERG N,HOEHNEL S,KUTTLER F,et al.High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays［J］.Nat Biomed Eng,2020,4(9):863-874.
［47］OZCELIK A,ABAS BI,ERDOGAN O,et al.On-chip organoid formation to study CXCR4/CXCL-12 chemokine microenvironment responses for renal cancer drug testing［J］.Biosensors(Basel),2022,12(12)：1177.
［48］ABDUL L,XU J,SOTRA A,et al.D-CryptO:deep learning-based analysis of colon organoid morphology from brightfield images［J］.Lab Chip,2022,22(21):4118-4128.
［49］LIBBY ARG,BRIERS D,HAGHIGHI I,et al.Automated design of pluripotent stem cell self-organization［J］.Cell Syst,2019,9(5):483-495.
［50］ZHOU Z,CONG L,CONG X.Patient-derived organoids in precision medicine:drug screening,organoid-on-a-chip and living organoid biobank［J］.Front Oncol,2021,11:762184.
［51］KONDO T.Current status and future outlook for patient-derived cancer models from a rare cancer research perspective［J］.Cancer Sci,2021,112(3):953-961.