|Table of Contents|

The progress of nanoknife in the treatment of pancreatic cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 15
Page:
2931-2937
Research Field:
Publishing date:

Info

Title:
The progress of nanoknife in the treatment of pancreatic cancer
Author(s):
DANG Xudong1; 2; QU Shibin1; LI Xiao1; LIU Zhengcai1
1.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710032,China;2.Medical School of Yan'an University,Shaanxi Yan'an 716000,China.
Keywords:
irreversible electroporation; nanoknife; pancreatic cancer; immunotherapy
PACS:
R735.9
DOI:
10.3969/j.issn.1672-4992.2023.15.032
Abstract:
Pancreatic cancer is a highly malignant solid tumor of the digestive tract,which has the characteristics of insidious onset,difficult early diagnosis,and strong tumor invasiveness.Clinically,most patients are already in the locally advanced stage of pancreatic cancer or have distant metastasis when they visit the clinic,and lack the opportunity for radical surgical resection,and the treatment effect is limited.Irreversible electroporation（also known as nanoknife) is a new technique for tumor ablation.The ablation area is formed by high-frequency electrical pulses between two electrodes and needles,and nanoscale pores are punched out on the surface of tumor cell membrane,resulting in the imbalance of intracellular environment and the apoptosis of tumor cells.Compared with the traditional physical therapy method,nanoknife has no thermal damage,no ionizing radiation,no pipe damage and other advantages.Recent clinical studies and practice have shown that nanoknife is a safe and effective tumor ablation method,which can effectively ablate pancreatic cancer tissue.Further studies have shown that nanoknife therapy can improve the immune microenvironment of pancreatic cancer,sensitize the efficacy of pancreatic cancer chemotherapy and immune checkpoint inhibitors,but further relevant clinical studies are still needed.This article mainly reviews the principle of nanoknife therapy,the research progress of pancreatic cancer nanoknife therapy and combined immunotherapy.

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Memo

Memo:
National Natural Science Foundation of China（No.81874051）;国家自然科学基金资助项目（编号：81874051）
Last Update: 2023-06-30