|Table of Contents|

Clinicopathological analysis of CDGSH iron sulfur domain 2 expression in gastric adenocarcinoma and its correlation with microvessel density

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 14
Page:
2673-2677
Research Field:
Publishing date:

Info

Title:
Clinicopathological analysis of CDGSH iron sulfur domain 2 expression in gastric adenocarcinoma and its correlation with microvessel density
Author(s):
ZOU Bingqing1; CHANG Yanhua1; DAI Youai2; LIANG Jiabei1
1.Department of Pathology;2.Clinical Research Center,the Affiliated Wuxi People's Hospital of Nanjing Medical University,Jiangsu Wuxi 214023,China.
Keywords:
CDGSH iron sulfur domain 2; gastric adenocarcinoma; vascular endothelial growth factor; microvessel density
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2023.14.018
Abstract:
Objective:To investigate the expression and clinical significance of CDGSH iron sulfur domain 2 (CISD2) in gastric adenocarcinoma,and its correlation with vascular endothelial growth factor (VEGF) and tumor microvessel density (MVD).Methods: Gastric adenocarcinoma tissues (cancer group,n=357) and their paired adjacent normal gastric mucosa tissues (control group,n=357) were included in this study.The expression of CISD2 and VEGF was detected by immunohistochemical stain.Vascular endothelial cells were labeled with CD34,and MVD was calculated.The expression of CISD2 and VEGF and its correlation with clinicopathological parameters was analyzed.The correlation between MVD,CISD2 and VEGF was analyzed.Results:The expression of CISD2 in the cancer group was higher than that in the control group (70.87% vs 25.77%,P＜0.001).The expression of VEGF in the cancer group was higher than that in the control group (61.34% vs 19.89%,P＜0.001).The expression of CISD2 and VEGF correlated with the depth of invasion,the grade of differentiation,lymph node metastasis,vascular and neural invasion and TNM stage of gastric adenocarcinoma (all P＜0.05).In the cancer group,CISD2 positive patients had higher MVD than CISD2 negative patients (35.67±6.06 vs 31.98±4.87,P＜0.001).VEGF positive patients also had higher MVD than VEGF negative patients in the cancer group (36.64±6.08 vs 31.38±4.54,P＜0.001).In the cancer group,a positive correlation between the expression of CISD2 and the expression of VEGF was observed (r=0.706,P＜0.001).Conclusion:CISD2 is overexpressed in gastric adenocarcinoma compared to adjacent normal gastric mucosa.The high expression of CISD2 correlated with histological differentiation,invasion and metastasis of gastric adenocarcinoma.CISD2 may be involved in the formation of microvessels in gastric adenocarcinoma.VEGF may play an important role with CISD2 in the formation of microvessels.

References:

［1］SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA:A Cancer Journal for Clinicians,2021,71(3):209-249.
［2］ZHANG Y,YU C.Bibliometric evaluation of publications (2000-2020) on the prognosis of gastric cancer［J］.Inquiry,2021,58(10251):635-648.
［3］LIAO HY,LIAIO B,ZHANG HH.CISD2 plays a role in age-related diseases and cancer［J］.Biomedicine & Pharmacotherapy,2021,138:111472.
［4］YANG L,HONG S,WANG Y,et al.A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma［J］.Oncotarget,2016,7(16):22720-22732.
［5］WANG L,OUYANG F,LIU X,et al.Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway［J］.Oncotarget,2016,7(4):3791-3805.
［6］LIU J,ZHANG Q,YANG D,et al.The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer［J］.Molecular Therapy.Nucleic Acids,2022,28:397-407.
［7］ZHANG Y,QU H.Expression and clinical significance of aquaporin-1,vascular endothelial growth factor and microvessel density in gastric cancer［J］.Medicine(Baltimore),2020,99(36):e21883.
［8］常艳华,梁加贝,周志毅,等.FOXO3a与乳腺浸润性导管癌血管生成的相关性［J］.中国现代医学杂志,2018,28(15):37-40. CHANG YH,LIANG JB,ZHOU ZY,et al.Effect of FOXO3a on angiogenesis in breast invasive ductal carcinoma［J］.China Journal of Modern Medicine,2018,28(15):37-40.
［9］MELINCOVICI CS,BOSCA AB,SUSMAN S,et al.Vascular endothelial growth factor (VEGF)-key factor in normal and pathological angiogenesis［J］.Romanian Journal of Morphology and Embryology,2018,59(2):455-467.
［10］KARAMI E,SABATIER JM,BEHDANI M,et al.A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis［J］.Journal of Enzyme Inhibitioon and Medicinal Chemistry,2020,35(1):1233-1239.
［11］HU Y,ZHANG Y,DING M,et al.Long noncoding RNA TMPO-AS1/miR-126-5p/BRCC3 axis accelerates gastric cancer progression and angiogenesis via activating PI3K/Akt/mTOR pathway［J］.Journal of Gastroenterology and Hepatology,2021,36(7):1877-1888.
［12］MAGDALENA B,KRZYSZTOF O,JACEK C.Assessing microvessel density in gastric carcinoma:a comparison of three markers［J］.Polish Journal of Pathology,2003,54(4):249-252.
［13］CHEN YF,WU CY,KIRBY R,et al.A role for the CISD2 gene in lifespan control and human disease［J］.Annals of The New York Academy of Sciences,2010,1201:58-64.
［14］SHEN ZQ,HUANG YL,TENG YC,et al.CISD2 maintains cellular homeostasis［J］.Biochimica et Biophysica Acta-Molecular Cell Research,2021,1868(4):118954.
［15］PADUCH R.The role of lymphangiogenesis and angiogenesis in tumor metastasis［J］.Cellular Oncology,2016,39(5):397-410.
［16］JACKSON AL,EISENHAUER EL,HERZOG TJ.Emerging therapies:angiogenesis inhibitors for ovarian cancer［J］.Expert Opinion on Emerging Drugs,2015,20(2):331-346.
［17］CARMELIET P.VEGF as a key mediator of angiogenesis in cancer［J］.Oncology,2005,3:4-10.
［18］温培楠,林明恕,金冕,等.二氢杨梅素通过 ERK/VEGFA/VEGFR2通路对体内外胃癌血管生成的影响［J］.中国癌症杂志,2020,30(2):113-121. WEN PN,LIN MS,JIN M,et al.Effect of dihydromyricetin on angiogenesis of gastric cancer in vitro and in vivo through ERK/VEGFA/VEGFR2 pathway［J］.Chinese Journal of Cancer,2020,30(2):113-121.

Memo

Memo:
江苏省省级高层次创新创业人才引进计划专项资金（编号：2019ZBQ）
Last Update: 1900-01-01