|Table of Contents|

Research progress of transient receptor potential channels in chemotherapy-induced peripheral neuropathy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 12
Page:
2368-2372
Research Field:
Publishing date:

Info

Title:
Research progress of transient receptor potential channels in chemotherapy-induced peripheral neuropathy
Author(s):
XING Haizhu; ZHU Jing
Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing University of Chinese Medicine，Jiangsu Nanjing 210000,China.
Keywords:
transient receptor potential channels; pain; chemotherapy-induced peripheral neuropathy; peripheral neuroprotection
PACS:
R730.6
DOI:
10.3969/j.issn.1672-4992.2023.12.035
Abstract:
The incidence of chemotherapy-induced peripheral neuropathy (CIPN) is 100% during the treatment with anticancer drugs,and the occurrence of CIPN is an extremely complex pathological process.Currently,there is still a lack of effective molecular methods in clinical practice,so it is urgent to find the key prevention and treatment targets.More and more studies have shown that transient receptor potential (TRP) channels are closely related to the occurrence and development of CIPN.Effective blocking of TRP channels can inhibit the development process of CIPN,and targeting of TRP channels brings a new penetrating point for the treatment of CIPN.Therefore,this paper mainly reviews relationship between TRP channels and CIPN,and the relevant research progress of targeting TRP channels in the prevention and treatment of CIPN,hoping to provide new ideas for the clinical prevention and treatment of CIPN.

References:

[1]CAVALETTI G,MARMIROLI P.Chemotherapy-induced peripheral neurotoxicity［J］.Curr Opin Neurol,2015,28(5):500-507.
[2]SPECK RM,SAMMEL MD,FARRAR JT,et al.Impact of chemotherapy-induced peripheral neuropathy on treatment delivery in nonmetastatic breast cancer［J］.Oncol Pract,2013,9(5):e234-e240.
[3]COLVIN LA.Chemotherapy-induced peripheral neuropathy:where are we now［J］.Pain,2019,160 Suppl 1(Suppl 1):S1-S10.
[4]RAMSEY IS,DELLING M,CLAPHAM DE.An introduction to TRP channels［J］.Annu Rev Physiol,2006,68:619-647.
[5]ZITT C,HALASZOVICH CR,LCKHOFF A.The TRP family of cation channels:probing and advancing the concepts on receptor-activated calcium entry［J］.Prog Neurobiol,2002,66(4):243-264.
[6]COSENS DJ,MANNING A.Abnormal electroretinogram from a Drosophila mutant［J］.Nature,1969,224(5216):285-287.
[7]PETERSEN CC,BERRIDGE MJ,BORGESE MF,et al.Putative capacitative calcium entry channels:expression of Drosophila trp and evidence for the existence of vertebrate homologues［J］.Biochem J,1995,311(Pt 1):41-44.
[8]CHANG Y,SCHLENSTEDT G,FLOCKERZI V,et al.Properties of the intracellular transient receptor potential (TRP) channel in yeast,Yvc1［J］.FEBS Lett,2010,584(10):2028-2032.
[9]VENKATACHALAM K,MONTELL C.TRP channels［J］.Annu Rev Biochem,2007,76:387-417.
[10]MARTN-BRNEZ M,GALEANO-OTERO I,DEL TORO R,et al.TRPC and TRPV channels' role in vascular remodeling and disease［J］.Int J Mol Sci,2020,21(17):6125.
[11]ERASLAN E,TANYELI A,POLAT E,et al.8-Br-cADPR,a TRPM2 ion channel antagonist,inhibits renal ischemia-reperfusion injury［J］.J Cell Physiol,2019,234(4):4572-4581.
[12]SIAU C,BENNETT GJ.Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy［J］.Anesth Analg,2006,102(5):1485-1490.
[13]FERNYHOUGH P,CALCUTT NA.Abnormal calcium homeostasis in peripheral neuropathies［J］.Cell Calcium,2010,47(2):130-139.
[14]YILMAZ E,GOLD MS.Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy［J］.Neuroscience,2015,300:210-218.
[15]NAZIROGLU M.Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous system［J］.J Recept Signal Transduct Res,2012,32(3):134-141.
[16]KAWASHIRI T,EGASHIRA N,KUROBE K,et al.L type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats［J］.Mol Pain,2012,8:7.
[17]DEMIRDAS A,NAZIROGLU M,VEY IS.Duloxetine reduces oxidative stress,apoptosis,and Ca2+ entry through modulation of TRPM2 and TRPV1 channels in the hippocampus and dorsal root ganglion of rats［J］.Mol Neurobiol,2017,54(6):4683-4695.
[18]BRANDOLINI L,D'ANGELO M,ANTONOSANTE A,et al.Chemokine signaling in chemotherapy-induced neuropathic pain［J］.Int J Mol Sci,2019,20(12):2904.
[19]SILVERMAN HA,CHEN A,KRAVATZ NL,et al.Involvement of neural transient receptor potential channels in peripheral inflammation［J］.Front Immunol,2020,11:590261.
[20]HONDA K,SHINODA M,KONDO M,et al.Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity［J］.Pain,2017,158(9):1754-1764.
[21]HUANG Y,CHEN SR,CHEN H,et al.Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain［J］.J Neurochem,2019,149(3):381-398.
[22]LIU B,TAI Y,CACERES AI,et al.Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice［J］.PLoS One,2016,11(11):e0165200.
[23]段波,徐天乐.TRP通道与信号转导［J］.生物物理学报,2005,21(4):245-260. DUAN B,XU TL.TRP channels and signal transduction［J］.Chinese Journal of Biophysics,2005,21(4):245-260.
[24]SHIM HS,BAE C,WANG J,et al.Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain［J］.Mol Pain,2019,15:1744806919840098.
[25]ROSSATO MF,RIGO FK,OLIVEIRA SM,et al.Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents［J］.Eur J Pharmacol,2018,828:42-51.
[26]DE LOGU F,TREVISAN G,MARONE IM,et al.Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4［J］.BMC Biol,2020,18(1):197.
[27]HARA T,CHIBA T,ABE K,et al.Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion［J］.Pain,2013,154(6):882-889.
[28]CHIBA T,OKA Y,SASHIDA H,et al.Vincristine-induced peripheral neuropathic pain and expression of transient receptor potential vanilloid 1 in rat［J］.J Pharmacol Sci,2017,133(4):254-260.
[29]CHUKYO A,CHIBA T,KAMBE T,et al.Oxaliplatin-induced changes in expression of transient receptor potential channels in the dorsal root ganglion as a neuropathic mechanism for cold hypersensitivity［J］.Neuropeptides,2018,67:95-101.
[30]KUAI CP,JU LJ,HU PP,et al.Corydalis saxicola alkaloids attenuate cisplatin-induced neuropathic pain by reducing loss of IENF and blocking TRPV1 activation［J］.Am J Chin Med,2020,48(2):407-428.
[31]HAO Y,LUO X,BA X,et al.Huachansu suppresses TRPV1 up-regulation and spinal astrocyte activation to prevent oxaliplatin-induced peripheral neuropathic pain in rats［J］.Gene,2019,680:43-50.
[32]WU Z,WANG S,WU I,et al.Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel［J］.Eur J Pain,2015,19(7):889-898.
[33]TAGUCHI KYOJI.Role of transient receptor potential channels in paclitaxel- and oxaliplatin-induced peripheral neuropathy［J］.Yakugaku Zasshi,2016,136(2):287-296.
[34]WANG H,SONG T,WANG W,et al.TRPM2 participates the transformation of acute pain to chronic pain during injury-induced neuropathic pain［J］.Synapse,2019,73(10):e22117.
[35]OZKAYA D,NAZIROGLU M.Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve［J］.J Recept Signal Transduct Res,2020,40(2):97-108.
[36] MIZUNO K,KONO T,SUZUKI Y,et al.Goshajinkigan,a traditional Japanese medicine,prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat［J］.J Pharmacol Sci,2014,125(1):91-98.
[37]KATO Y,TATEAI Y,OHKUBO M,et al.Goshajinkigan reduced oxaliplatin-induced hypersensitivity to cold sensation and its effect would be related to suppression of the expression of TRPM8 and TRPA1 in rats［J］.Anticancer Drugs,2014,25(1):39-43.
[38]RIMOLA V,HAHNEFELD L,ZHAO J,et al.Lysophospholipids contribute to oxaliplatin-induced acute peripheral pain［J］.J Neurosci,2020,40(49):9519-9532.
[39]PAN Y,CHEN F,HUANG S,et al.TRPA1 and TRPM8 receptors may promote local vasodilation that aggravates oxaliplatin-induced peripheral neuropathy amenable to 17β-estradiol treatment［J］.Curr Neurovasc Res,2016,13(4):309-317.
[40]MIYANO K,SHIRAISHI S,MINAMI K,et al.Carboplatin enhances the activity of human transient receptor potential Ankyrin 1 through the cyclic AMP-protein kinase A-A-kinase anchoring protein (AKAP) pathways［J］.Int J Mol Sci,2019,20(13):3271.
[41]NAKAGAWA T,KANEKO S.Roles of transient receptor potential Ankyrin 1 in oxaliplatin-induced peripheral neuropathy［J］.Biol Pharm Bull,2017,40(7):947-953.
[42]AMIRKHANLOO F,KARIMI G,YOUSEFI-MANESH H,et al.The protective effect of modafinil on vincristine-induced peripheral neuropathy in rats:A possible role for TRPA1 receptors［J］.Basic Clin Pharmacol Toxicol,2020,127(5):405-418.
[43]BOIKO N,MEDRANO G,MONTANO E,et al.TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids［J］.PLoS One,2017,12(10):e0186888.

Memo

Memo:
江苏省科技项目（面上项目）（编号：BE2018717）
Last Update: 1900-01-01