|Table of Contents|

Progress in prevention and treatment of chemoradiotherapy associated oral mucositis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 12
Page:
2347-2352
Research Field:
Publishing date:

Info

Title:
Progress in prevention and treatment of chemoradiotherapy associated oral mucositis
Author(s):
YAN HuiyingHONG ZhichaoZHANG YujiaoTANG RuiMAO RuiTANG Yiqun
China Pharmaceutical University,Jiangsu Nanjing 211198,China.
Keywords:
oral mucositiscancerchemotherapyradiotherapy
PACS:
R730.6
DOI:
10.3969/j.issn.1672-4992.2023.12.031
Abstract:
Oral mucositis is a common complication of cancer patients receiving chemoradiotherapy,which is highly related to the patients' life quality and clinical efficacy.Thus the management of oral mucositis is becoming an important part of pharmaceutical care of cancer patients.In this paper,the current status of prevention and treatment of oral mucositis induced by cancer therapy was introduced from the perspectives of its pathogenesis,clinical manifestations and clinical treatment regimens.At the same time,we described the clinical application of "wet healing" at the present stage,with a view to applying this technology combining with other drugs in order to improve the quality of wound healing.

References:

[1]MCGUIRE DB,FULTON JS,PARK J,et al.Systematic review of basic oral care for the management of oral mucositis in cancer patients[J].Support Care Cancer,2013,21(11):3165-3177.
[2]GOUVA DE LIMA A,VILLAR RC,DE CASTRO G,et al.Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy:a phase III randomized study[J].Int J Radiat Oncol Biol Phys,2012,82(1):270-275.
[3]ELAD S,CHENG KKF,LALLA RV,et al.MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy[J].Cancer,2020,126(19):4423-4431.
[4]ELTING LS,KEEFE DM,SONIS ST,et al.Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy:demonstration of increased frequency,severity,resistance to palliation,and impact on quality of life[J].Cancer,2008,113(10):2704-2713.
[5]NISHIMURA N,NAKANO K,UEDA K,et al.Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas[J].Support Care Cancer,2012,20(9):2053-2059.
[6]方颖,黄丽华.非药物预防和处理癌症化疗所致口腔黏膜炎的研究进展[J].护理与康复,2019,18(05):45-48. FANG Y,HUANG LH.Research progress of non-drug prevention and treatment of oral mucositis caused by cancer chemotherapy[J].Nursing and Rehabilitation,2019,18(05):45-48.
[7]DAVY C,HEATHCOTE S.A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients[J].Support Care Cancer,2021,29(4):2187-2202.
[8]SONIS ST.Oral mucositis in cancer therapy[J].The Journal of Supportive Oncology,2004,2(6 Suppl 3):3-8.
[9]康敏.中国鼻咽癌放射治疗指南(2020版)[J].中华肿瘤防治杂志,2021,28(03):167-177. KANG M.Chinese guidelines for radiotherapy of nasopharyngeal carcinoma[J].Chinese Journal of Cancer Prevention and Treatment,2021,28(03):167-177.
[10]GU J,ZHU S,LI X,et al.Effect of amifostine in head and neck cancer patients treated with radiotherapy:a systematic review and meta-analysis based on randomized controlled trials[J].PLoS One,2014, 9(5):95-96.
[11]ELAD S,RABER-DURLACHER JE,BRENNAN MT,et al.Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients:a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)[J].Support Care Cancer,2015,23(1):223-236.
[12]田莹,程永昌,王生梅.重组人粒细胞巨噬细胞集落刺激因子辅助治疗急性髓系白血病诱导化学治疗并发口腔黏膜炎的效果分析[J].中国临床实用医学,2020,11(01):47-50. TIAN Y,CHENG YC,WANG SM.Effects of recombinant human granulocyte macrophage colony stimulating factor on oral mucositis induced by chemotherapy in acute myeloid leukemia[J].Chinese Journal of Clinical Practical Medicine,2020,11(01):47-50.
[13]李显.金因肽配合口腔护理治疗化疗引起口腔溃疡的疗效观察[J].中医临床研究,2013, 5(18):112-113. LI X.Observation on the curative effect of Jinyin Peptide combined with oral nursing in the treatment of chemotherapy-induced oral ulcer[J].Clinical Study of Chinese Medicine,2013,5(18):112-113.
[14]史根芽,刘宇,史铁英.口腔冷冻疗法在癌症患者口腔黏膜炎中的应用研究进展[J].中华现代护理杂志,2020,26(13):1807-1811. SHI GY,LIU Y,SHI TY.Oral cryotherapy in patients with oral mucositis[J].Chines Journal of Modern Nursing,2020,26(13):1807-1811.
[15]邢龙,布仁巴图.氨磷汀在肿瘤患者化疗中的应用[J].中国社区医师,2015,31(29):8-11. XING L,BU RBT.Application of amifostine in chemotherapy of tumor patients[J].Chinese Community Physicians,2015,31(29):8-11.
[16]宋元玲,冯驭驰,任辉,等.血清锌、硒、铁含量与复发性口腔溃疡的相关性研究[J].中国临床医生杂志,2016,44(08):83-85. SONG YL,FENG YC,REN H,et al.Study on the relationship between serum zinc,selenium and iron content and recurrent oral ulcer[J].Chin J Clinicol,2016,44(08):83-85.
[17]黄军亚.加味黄芪建中汤漱服联合复方氯己定含漱液治疗复发性口腔溃疡的疗效观察[J].医学理论与实践,2020,33(12):1987-1989. HUANG JY.Observation on the curative effect of gargle of Modified Huangqi Jianzhong Decoction combined with compound chlorhexidine gargle in the treatment of recurrent oral ulcer[J].Medical Theory and Practice,2020,33(12):1987-1989.
[18]王祥军,王进.复方甘菊利多卡因凝胶联合康复新液治疗复发性口腔溃疡[J].河南医学研究,2020,29(26):4938-4940. WANG XJ,WANG J.Treatment of recurrent oral ulcer with compound camomlidocaine gel combined with kangfuxin solution[J].Journal of Henan Med Research,2020,29(26):4938-4940.
[19]郝琦,阿达来提·麻合苏提.玉女煎治疗急性放射性口腔黏膜炎及口干症临床疗效观察[J].四川中医,2016,34(12):166-168. HAO Q,ADALAITI·MAHESUTI.Clinical observation of Yunv Decoction in treatment of acute radiation oral mucositis and xerostomia[J].Sichuan Journal of Traditional Chinese Medicine,2016,34(12):166-168.
[20]吕霞,王冰冰,徐丹,等.口炎宁合剂治疗放射性口腔黏膜炎60例[J].河南中医,2019,39(08):1243-1246. LYU X,WANG BB,XU D,et al.Treatment of 60 cases of radioactive oral mucositis with Kouyanning Mixture[J].Henan Traditional Chinese Medicine,2019,39(08):1243-1246.
[21]夏天,邢育珍,李静,等.养阴清肺汤对急性放射性口腔炎患者免疫功能、炎症细胞因子的影响[J].中国中医急症,2020,29(02):309-311. XIA T,XING YZ,LI J,et al.Effects of Yangyin Qingfei Decoction on immune function and inflammatory cytokines in patients with acute radioactive stomatitis[J].Chinese Journal of Medical Emergency,2020,29(02):309-311.
[22]张海波,田蓓,任崇敏,等.金刺参九正合剂及其主要成分治疗癌症效果的Meta分析[J].现代肿瘤医学,2010,18(04):796-800. ZHANG HB,TIAN B,REN CM,et al.Meta analysis of the effect of Ai Fu Ning and it's primary components in the treatment of carcinoma[J].Modern Oncology,2010,18(04):796-800.
[23]林高娟,杨敏,唐玉平,等.穿心草防治鼻咽癌放射性口腔黏膜反应的临床研究[J].现代肿瘤医学,2012,20(09):1817-1819. LIN GJ,YANG M,TANG YP,et al.Clinical research of Chuanxincao in the prevention and treatment of radiation-induced oral mucosa reaction in patients with nasopharyngeal cancer[J].Modern Oncology,2012,20(09):1817-1819.
[24]BLIJLEVENS N,SONIS S.Palifermin (recombinant keratinocyte growth factor-1):a pleiotropic growth factor with multiple biological activities in preventing chemotherapy-and radiotherapy-induced mucositis[J].Ann Oncol,2007,18(5):817-826.
[25]KUO CC,WANG RH,WANG HH,et al.Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis[J].Support Care Cancer,2018,26(12):4001-4009.
[26]WATANABE T,ISHIHARA M,MATSUURA K,et al.Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer[J].Int J Cancer,2010,127(8):1984-1990.
[27]ANDERSON CM,LEE CM,SAUNDERS DP,et al.Phase IIb,randomized,double-blind trial of GC4419 versus placebo to reduce severe oral mucositis due to concurrent radiotherapy and cisplatin for head and neck cancer[J].J Clin Oncol,2019,37(34):3256-3265.
[28]RILEY P,GLENNY AM,WORTHINGTON HV,et al.Interventions for preventing oral mucositis in patients with cancer receiving treatment:cytokines and growth factors[J].Cochrane Database Syst Rev,2017,11(11):Cd011990.
[29]SHARMA A,RATH GK,CHAUDHARY SP,et al.Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer:a randomized double-blind placebo-controlled study[J].Eur J Cancer,2012,48(6):875-881.
[30]HUDSON DE,HUDSON DO,WININGER JM,et al.Penetration of laser light at 808 and 980 nm in bovine tissue samples[J].Photomed Laser Surg,2013,31(4):163-168.
[31]PERALTA-MAMANI M,DA SILVA BM,DA SILVA PINTO AC,et al.Low-level laser therapy dosimetry most used for oral mucositis due to radiotherapy for head and neck cancer:a systematic review and meta-analysis[J].Crit Rev Oncol Hematol,2019,138:14-23.
[32]ANTUNES HS,HERCHENHORN D,SMALL IA,et al.Long-term survival of a randomized phase III trial of head and neck cancer patients receiving concurrent chemoradiation therapy with or without low-level laser therapy (LLLT) to prevent oral mucositis[J].Oral Oncol,2017,71:11-15.
[33]LALLA RV,CHOQUETTE LE,CURLEY KF,et al.Randomized double-blind placebo-controlled trial of celecoxib for oral mucositis in patients receiving radiation therapy for head and neck cancer[J].Oral Oncol,2014,50(11):1098-1103.
[34]JOHANSSON JE,BRATEL J,HARDLING M,et al.Cryotherapy as prophylaxis against oral mucositis after high-dose melphalan and autologous stem cell transplantation for myeloma:a randomised,open-label,phase 3,non-inferiority trial[J].Bone Marrow Transplant,2019,54(9):1482-1488.
[35]ANTUNES HS,HERCHENHORN D,SMALL IA,et al.Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation[J].Radiother Oncol,2013,109(2):297-302.
[36]ALLISON RR,AMBRAD AA,ARSHOUN Y,et al.Multi-institutional,randomized,double-blind,placebo-controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck[J].Cancer,2014,120(9):1433-1440.
[37]ZHENG B,CHOQUETTE LE,CURLEY KF,et al.Randomized,double-blind,placebo-controlled trial of Shuanghua Baihe tablets to prevent oral mucositis in patients with nasopharyngeal cancer undergoing chemoradiation therapy[J].Int J Radiat Oncol Biol Phys,2018,100(2):418-426.
[38]YEN SH,WANG LW,LIN YH,et al.Phenylbutyrate mouthwash mitigates oral mucositis during radiotherapy or chemoradiotherapy in patients with head-and-neck cancer[J].Int J Radiat Oncol Biol Phys,2012,82(4):1463-1470.
[39]郑彩霞,刘洋,韩金花.肺癌靶向药物相关性皮疹、黏膜炎的中医药治疗[J].新中医,2019,51(12):322-324. ZHENG CX,LIU Y,HAN JH.Treatment of lung cancer with targeted drug associated rash and mucositis in traditional Chinese medicine[J].New Chinese Medicine,2019,51(12):322-324.
[40]张誉华,龙麟,杨婕,等.肺癌靶向药物相关皮肤不良反应的中西医治疗进展[J].中国中医基础医学杂志,2016,22(02):287-289. ZHANG YH,LONG L,YANG J,et al.Western and Chinese medicine treatment progress of adverse skin reactions associated with lung cancer targeted drugs[J].Journal of Basic Chinese Medicine,2016,22(02):287-289.
[41]刘云霞,徐叶峰,李帅,等.三草愈疡汤防治骨肉瘤大剂量甲氨蝶呤化疗后口腔黏膜炎的临床研究[J].中华中医药杂志,2019,34(10):4942-4946. LIU YX,XU YF,LI S,et al.Clinical study of Sancaoyuyang Decoction in the treatment of oral mucositis after high-dose methotrexate chemotherapy[J].Chinese Journal of Traditional Chinese Medicine,2019,34(10):4942-4946.
[42]王教成,张相国,张群功,等.重组人表皮生长因子外用溶液治疗中年鼻咽癌患者放射性口腔黏膜炎的疗效观察[J].福建医药杂志,2019,41(01):76-77. WANG JC,ZHANG XG,ZHANG QG,et al.Effects of recombinant human epidermal growth factor on oral mucositis in patients with nasopharyngeal carcinoma[J].Fujian Medical Journal,2019,41(01):76-77.
[43]代欣玥,张菀桐,刘艳,等.高压氧治疗糖尿病足的系统评价再评价[J].中国循证医学杂志,2020,20(07):809-816. DAI XY,ZHANG YT,LIU Y,et al.Systematic evaluation and reevaluation of hyperbaric oxygen therapy for diabetic foot[J].Chinese Journal of Evidence-based Medicine,2020,20(07):809-816.
[44]肖岷,郜红梅,王立红,等.持续吹氧法在Ⅳ期压疮治疗中的效果观察[J].中国实用医药,2012,7(16):74-75. XIAO M,HAO HM,WANG LH,et al.Effect of continuous oxygen blowing in treatment of stage IV pressure ulcers[J].Chinese Journal of Practical Medicine,2012,7(16):74-75.
[45]肖红梅,邹彦.康复新液氧气雾化吸入防治鼻咽癌放射性口腔黏膜反应的临床观察[J].现代肿瘤医学,2015,23(05):627-629. XIAO HM,ZOU Y.Clinical observation of kangfuxin liquid oxygen aerosol inhalation in the prevention and treatment of nasopharyngeal carcinoma radiation oral mucosa reaction[J].Modern Oncology,2015,23(05):627-629.
[46]莫怀飘,林进姬,罗仕珍.湿性愈合敷料应用在Ⅱ、Ⅲ期压力性损伤患者中的护理研究[J].中外医学研究,2021,19(12):98-100. MO HP,LIN JJ,LUO SZ.Nursing study of wet healing dressing in patients with stage Ⅱ and Ⅲ stress injury[J].Chinese Journal of Medical Research,2021,19(12):98-100.
[47]孙玉花.慢性伤口愈合护理中采取湿性愈合理念的应用效果[J].中外医疗,2020,39(26):157-159. SUN YH.Effect of wet healing concept on nursing of chronic wound healing[J].Chinese and Foreign Medical Journal,2020,39(26):157-159.
[48]周娴,孙丽超,陈虹.湿性护创敷料对小儿烧伤创面护理的效果观察[J].中国医疗美容,2020,10(08):109-112. ZHOU X,SUN LC,CHEN H.Observation of the effect of wet wound dressing on the care of pediatric burn wounds[J].China Medical Aesthetics,2020,10(08):109-112.
[49]中国临床肿瘤学会抗肿瘤药物安全管理专家委员会,中国临床肿瘤学会肿瘤支持与康复治疗专家委员会.抗肿瘤治疗引起急性口腔黏膜炎的诊断和防治专家共识[J].临床肿瘤学杂志,2021,26(05):449-459. ASMC,SCRC.Diagnosis and prevention of acute oral mucositis induced by antitumor therapy[J].Chinese Clinical Oncology,2021,26(05):449-459.

Memo

Memo:
-
Last Update: 1900-01-01