|Table of Contents|

Changes of CT image characteristics in radiotherapy of locally advanced esophageal squamous cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 11
Page:
2072-2079
Research Field:
Publishing date:

Info

Title:
Changes of CT image characteristics in radiotherapy of locally advanced esophageal squamous cell carcinoma
Author(s):
LIU Yimei; CHEN Meining; WANG Bin; QIU Bo; ZHANG Jun; DENG Xiaowu; PENG Yinglin
Department of Radiation Oncology，Sun Yat-sen University Cancer Center/State Key Laboratory of Oncology in South China/Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy，Guangdong Guangzhou 510060，China.
Keywords:
locally advanced esophageal squamous cell carcinoma; radiomics; radiotherapy; computed tomography; target volume
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.11.019
Abstract:
Objective:To extract and screen the radiomic features of esophageal cancer planning CT and weekly repeated CT images，and to analyze the correlation between their feature changes and radiotherapy response.Methods:A total of 15 patients with locally advanced esophageal squamous cell carcinoma who received radiotherapy were re-scanned by simulated CT after weekly treatment，and the target volume were delineated on 5 repeated CT images by the same physician.The radiomic features of the target volume in the planned CT and repeated scan CT images were extracted by Python programming and statistically analyzed，and the radiomic features which were strongly related to the weeks of radiotherapy，the volume change of the target volume and the treatment outcome（2-year survival) were screened，and the correlation of the features was statistically analyzed by Spearman correlation and point biserial correlation analysis.Results:In the radiomic feature analysis，1 688 features were extracted from CTV1 and CTV2 respectively，and 10 features were most strongly related to treated week numbers，target volume changes and treatment outcome（2-year survival).The radiomic features were negatively correlated with the weeks of radiotherapy（<-0.6)，positively correlated with volume changes（>0.6)，and weakly correlated with treatment outcome（2-year survival).The correlation coefficients were （-0.81~-0.67)，(0.72~0.99) and （-0.37~0.52)，respectively.Conclusion:The CT delta-radiomic features of the target volume during radiotherapy for esophageal cancer are correlated with the treatment times，target volume and treatment outcome.Based on the DRFs of CT，the prognosis of esophageal cancer can be predicted.

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Memo

Memo:
National Natural Science Foundation of China（No.12005316）;国家自然科学基金(编号：12005316)；中华国际医学交流基金会肿瘤精准放疗星火计划(编号：2019-N-11-20)；广东省广州市科技计划项目(编号：202206010154，202206010180)
Last Update: 2023-04-28