|Table of Contents|

The mechanism of DRR1 on the regulation of neuroblastoma cell differentiation

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 11
Page:
2020-2026
Research Field:
Publishing date:

Info

Title:
The mechanism of DRR1 on the regulation of neuroblastoma cell differentiation
Author(s):
SU Qianqian1; LEI Ming1; SONG Jingshu1; LIU Yuxi1; CAI Yunlong1; CHEN Xiao1; ZHANG Min2; ZHANG Zhong2; MU Ping3
1.Basic Medical School,Shenyang Medical College,Liaoning Shenyang 110034,China;2.Department of Pathology,Basic Medical School,Shenyang Medical College,Liaoning Shenyang 110034,China;3.Department of Physiology,Basic Medical School,Shenyang Medical College,Liaoning Shenyang 110034,China.
Keywords:
DRR1; neuroblastoma; differentiation; cell cycle
PACS:
R739.4
DOI:
10.3969/j.issn.1672-4992.2023.11.009
Abstract:
Objective:To explore the role and the mechanism of DRR1 on the neuroblastoma cell differentiation.Methods:To analyze the cell differentiation status,the cell cycle and the expression of the candidate downstream genes of DRR1 in DRR1 overexpressed or DRR1 knocked down neuroblastoma cells.To analyze the correlation of the expression of DRR1 and the expression of its candidate downstream genes in neuroblastoma patients’ database.To analyze the expression of the candidate downstream genes of DRR1 in neuroblastoma cells after the differentiation induction.Results:Overexpression of DRR1 promoted the differentiation of neuroblastoma cells.Downregulation of DRR1 promoted the G1/S transition,and overexpression of DRR1 suppressed the G1/S transition in neuroblastoma cells.The expression of the candidate downstream genes of DRR1 was changed in DRR1 overexpressed neuroblastoma cells.There was significant correlation between the expression of DRR1 and the expression of its candidate downstream genes in the clinical neuroblastoma patients’ database.The expression of the candidate downstream genes of DRR1 was changed according to the differentiation status of neuroblastoma cells.Conclusion:DRR1 regulates cell differentiation in neuroblastoma by modulating the expression of its downstream genes.

References:

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Last Update: 2023-04-28