|Table of Contents|

Analysis of missed diagnosis of Langerhans cell histiocytosis in an adult:A case report and literature review

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 10
Page:
1890-1893
Research Field:
Publishing date:

Info

Title:
Analysis of missed diagnosis of Langerhans cell histiocytosis in an adult:A case report and literature review
Author(s):
WANG Zhihao1; QIU Ruoqiong2; TAN Jin3
1.Changsha Stomatological Hospital，Hunan Changsha 410029,China;2.The First Affiliated Hospital of Hunan Normal University,Hunan Changsha 410005,China；3.The First Affiliated Hospital of Hunan University of Chinese Medicine,Hunan Changsha 410007,China.
Keywords:
Langerhans cell histiocytosis; adult; missed diagnosis
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2023.10.022
Abstract:
Objective:To investigate the causes of missed diagnosis of Langerhans cell histiocytosis(LCH) so as to reduce the missed diagnosis rate and improve understanding of the disease.Methods：The clinical features,diagnosis and treatment of one case patient with LCH and the causes of missed diagnosis were retrospectively analyzed and the relevant literature at home and abroad were reviewed．Results：A 27-year-old male,presented with bilateral mandibular swelling and chest discomfort.Oral pathology biopsy was performed in May and the results suggested that CD1a（-）,CD207（-）,S-100（±）,resulting in missed diagnosis and failure to provide symptomatic treatments of LCH.Transbronchial lung biopsy was performed in August and the results suggested that CD1a（+）,CD207（+）,S-100（+）,resulting in definitive diagnosis.Conclusion：The possibility of LCH should be considered when the lesion of jaw bones are accompanied by the lesion of lung or bone tissues.Immunohistochemistry needs to be performed as soon as possible and proper pathological examination should be used to avoid missed diagnosis.After diagnosis of the LCH,relevant systemic examinations should be completed to avoid the condition of missing other target organs.And a rational treatment planning should be used to obtain better therapeutic effect and prognosis based on systemic organ involvement.

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Memo

Memo:
National Natural Science Foundation of China(No.81874496）；国家自然科学基金面上项目（编号：81874496）；湖南省中医药管理局重点项目（编号：201808）；湖南中医药大学口腔医学一级学科开放基金重点项目（编号：2019KQYY01）
Last Update: 1900-01-01