|Table of Contents|

The role and research progress of tumor-associated macrophages in lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 10
Page:
1960-1963
Research Field:
Publishing date:

Info

Title:
The role and research progress of tumor-associated macrophages in lung cancer
Author(s):
REN Mingmin; ZHAO Yanbin
Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081，China.
Keywords:
lung cancer; tumor-associated macrophages; tumor microenvironment
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2023.10.038
Abstract:
Tumor-associated macrophages (TAMs) are important inflammatory cells in the tumor microenvironment.Under the action of various stimuli,TAMs can be divided into classical activation (M1) and alternating activation (M2) types.M1-TAMs has the effect of inhibiting the malignant tumor activity,and M2-TAMs has the effect of promoting the development of the malignant tumor.It is shown that TAMs in tumor tissues are mainly M2 type and can secrete a variety of chemokines and cytokines to promote tumor proliferation,invasion and metastasis,angiogenesis and drug resistance,then reduce the immune effect of the body on the tumor.This review presents the phenotype of TAMs and new advances in its mechanism of action in lung cancer.

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Memo

Memo:
吴阶平医学基金(编号：320.6750.2021-1-20)
Last Update: 1900-01-01