|Table of Contents|

Application of rocuronium priming principle for general anesthesia induction on intraoperative neuromonitoring in thyroid tumor surgery

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 10
Page:
1904-1908
Research Field:
Publishing date:

Info

Title:
Application of rocuronium priming principle for general anesthesia induction on intraoperative neuromonitoring in thyroid tumor surgery
Author(s):
PAN Wei1; YAO Lan1; ZHANG Yongqiang1; FENG Xuexin2
1.Department of Anesthesiology,Peking University International Hospital,Beijing 102206,China；2.Department of Anesthesiology,Xuanwu Hospital Capital Medical University,Beijing 100053,China.
Keywords:
priming principle; rocuronium; mivacurium; intraoperative neuromonitoring; thyroid tumor surgery
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2023.10.025
Abstract:
Objective:To observe the effect of priming low-dose rocuronium on conditions of tracheal intubation in rapid induced general anesthesia with mivacurium and intraoperative neuromonitoring(IONM) of thyroid tumor surgery.Methods:A total of 90 patients who had general anesthesia for thyroid tumor surgery with IONM since Jan 2019 to Oct 2021 were analyzed retrospectively.According to different ways of administration,they were divided into 3 groups:Group M(mivacurium group) received intravenous injection of 0.15 mg/kg mivacurium during induction.Group R(rocuronium group)received intravenous injection of 0.6 mg/kg rocuronium during induction.Group P (priming rocuronium group) received intravenous injection of low-dose(0.06 mg/kg) rocuronium at the beginning of induction,followed by intravenous injection of 0.15 mg/kg mivacurium about 3 minutes later,30 patients in each group.General conditions were compared.Duration from completion of muscle relaxant injection to TOF value drops to minimum (T1).Duration from completion of muscle relaxant injection to endotracheal intubation is done(T2).Endotracheal intubation condition scoring.Guration from completion of muscle relaxant injection to TOF value recovers to 75% (T3) and 90%(T4).IONM response and postoperative complications were recorded.Results:T1 and T2 of group P was significantly shorter than group M.Cooper's scoring for grading intubation result from group P was similar to group R,which was superior to score in group M.There was no statistically significant difference between group P and group M in T3 and T4,which was shorter than group R.IONM satisfaction of group R was relatively low,and had the statistical differences with group P and group M.Group R may affect the accuracy of the initial IONM in thyroid surgery,while group M and P have no effect on it.Conclusion:Priming low-dose rocuronium during induction of general anesthesia can accelerate the peak time of mivacurium,with better endotracheal intubation condition and no impact on IONM of thyroid tumor surgery.

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