|Table of Contents|

Influencing factors of lymph node skip metastasis after esophageal cancer surgery and its relationship with prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 09
Page:
1665-1671
Research Field:
Publishing date:

Info

Title:
Influencing factors of lymph node skip metastasis after esophageal cancer surgery and its relationship with prognosis
Author(s):
LI Runxiao; SHEN Wenbin; CAO Yankun; DENG Wenzhao
Department of Radiation Oncology,the Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang 050011,China.
Keywords:
esophageal cancer; surgical resection; nodal skip metastasis; prognosis
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.09.015
Abstract:
Objective：To investigate the prognostic value of skip lymph node metastasis (NSM) in patients with positive lymph nodes after esophageal cancer surgery and its influencing factors.Methods：The clinicopathological data of 362 patients with positive lymph nodes after esophageal cancer surgery were retrospectively analyzed.The patients were divided into NSM group and non-lymph node skipping metastasis (NNSM) group.Using SPSS 25.0 statistical software to statistically analyze the differences in the prognosis of the two groups of patients,the independent risk factors that affect the appearance of NSM,the independent prognostic factors of the entire group of patients,and the failure mode of the two groups of patients.The bias and confounding variables were reduced by PSM analysis.Results：The median OS time and PFS time of the entire group of patients were 26.0 months (95%CI:23.1~28.9) and 18.0 months (95%CI:14.8~21.2),respectively.The median OS time of patients in the NSM group and NNSM group were 33.0 months and 24.0 months,respectively (χ2=8.025,P=0.005).The median PFS time were 24.1 months and 14.3 months,respectively (χ2=5.012,P=0.025).The results of Logistics multivariate analysis showed that the lesion location and pathological N stage of esophageal cancer were independent risk factors that affected the appearance of NSM in patients (P=0.000,0.000).The 1,3 and 5 years OS and PFS of NSM after PSM were also significantly better than those of NNSM group (χ2=5.301,4.581;P=0.021,0.032).COX multivariate analysis showed that the patient's gender,age,esophageal cancer lesion location,pathological N stage,and lymph node metastasis status were all independent risk factors affecting the patient's OS and PFS (P=0.024,0.004,0.000,0.016,0.001 and 0.009,0.008,0.000,0.010,0.006).Conclusion：NSM is a good predictor of prognosis for patients with positive lymph nodes after esophageal cancer surgery,and the lesion location and pathological N stage are independent risk factors that affect the appearance of NSM.There was no significant difference in failure mode between NSM and NNSM groups.The final research conclusions need to be further carried out multi-center,prospective randomized controlled studies of large cases.

References:

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Last Update: 2023-03-30