［1］LEE S,SCHMITT CA.The dynamic nature of senescence in cancer［J］.Nat Cell Biol,2019,21(1):94-101.
［2］SUN Y,COPPE JP,LAM EW.Cellular senescence:The sought or the unwanted［J］.Trends Mol Med,2018,24(10):871-885.
［3］CALCINOTTO A,KOHLI J,ZAGATO E,et al.Cellular senescence:Aging,cancer,and injury［J］.Physiol Rev,2019,99(2):1047-1078.
［4］TUBITA A,LOMBARDI Z,TUSA I,et al.Inhibition of ERK5 elicits cellular senescence in melanoma via the cyclin-dependent kinase inhibitor p21 ［J］.Cancer Res,2022,82(3):447-457.
［5］SCHMITT CA,WANG B,DEMARIA M.Senescence and cancer-role and therapeutic opportunities［J］.Nat Rev Clin Oncol,2022,19(10):619-636.
［6］YANG B,DAMODARAN S,KHEMEES TA,et al.Synthetic lethal metabolic targeting of androgen-deprived prostate cancer cells with metformin ［J］.Mol Cancer Ther,2020,19(11):2278-2287.
［7］AMR O,MONICA CB,JULIAN LM,et al.G3BP1 controls the senescence-associated secretome and its impact on cancer progression ［J］.Nat Commun,2020,11(1):4979.
［8］TAKASUGI M,YOSHIDA Y,OHTANI N.Cellular senescence and the tumour microenvironment ［J］.Mol Oncol,2022,16(18):3333-3351.
［9］CHING WL,PO HC,T JY,et al.WWOX modulates ROS-dependent senescence in bladder cancer［J］.Molecules,2022,27(21):7388.
［10］BAOCHI O,YUAN L,ZONG XG,et al.Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation［J］.Cell Death Dis,2022,13(10):905.
［11］ HUANG Y,YANG X,MENG Y,et al.The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages ［J］.Cell Biosci,2021,11(1):173.
［12］XU Q,LONG Q,ZHU D,et al.Targeting amphiregulin(AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand(PD-L1)-mediated immunosuppression［J］.Aging Cell,2019,18(6):e13027.
［13］FALCI C,GIANESIN K,SERGI G,et al.Immune senescence and cancer in elderly patients:results from an exploratory study［J］.Exp Gerontol,2013,48(12):1436-1442.
［14］GIUNCO S,PETRARA MR,BERGAMO F,et al.Immune senescence and immune activation in elderly colorectal cancer patients［J］.Aging(Albany NY),2019,11(11):3864-3875.
［15］HIEBERT P,WIETECHA MS,CANGKRAMA M,et al.Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome［J］.Dev Cell,2018,46(2):145-161.
［16］MASAKI T,YUYA Y,NAOKO O.Cellular senescence and the tumour microenvironment ［J］.Mol Oncol,2022,16(18):3333-3351.
［17］MASAKI T,YUYA Y,EIJI H,et al.The role of cellular senescence and SASP in tumour microenvironment ［J/OL］.FEBS J［2022-02-02］.https://doi.org/10.1111/febs.6381.
［18］GUILHERME P,SONIA A,FIONA R,et al.Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion［J］.Cell,2021,184(20):5230-5246.
［19］ORTIZ-MONTERO P,LONDONO-VALLEJO A,VERNOT JP.Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line［J］.Cell Commun Signal,2017,15(1):17.
［20］DI G,LIU Y,LU Y,et al.IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells［J］.PLoS One,2014,9(11):e113572.
［21］LUO X,FU Y,LOZA AJ,et al.Stromal-initiated changes in the bone promote metastatic niche development［J］.Cell Rep,2016,14(1):82-92.
［22］YAMAO T,YAMASHITA YI,YAMAMURA K,et al.Cellular senescence,represented by expression of Caveolin-1,in cancer-associated fibroblasts promotes tumor invasion in pancreatic cancer［J］.Ann Surg Oncol,2019,26(5):1552-1559.
［23］WANG T,NOTTA F,NAVAB R,et al.Senescent carcinoma-associated fibroblasts upregulate IL8 to enhance prometastatic phenotypes［J］.Mol Cancer Res,2017,15(1):3-14.
［24］FARSAM V,BASU A,GATZKA M,et al.Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration［J］.Oncotarget,2016,7(50):83554-83569.
［25］MILANOVIC M,FAN DNY,BELENKI D,et al.Senescence-associated reprogramming promotes cancer stemness［J］.Nature,2018,553(7686):96-100.
［26］WANG Y,ZHANG H,WANG M,et al.CCNB2/SASP/cathepsin B & PGE2 axis induce cell senescence mediated malignant transformation［J］.Int J Biol Sci,2021,17(13):3538-3553.
［27］PANNEER SELVAM S,ROTH BM,NGANGA R,et al.Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3［J］.J Biol Chem,2018,293(25):9784-9800.
［28］LI B,HOU D,GUO H,et al.Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells［J］.Sci Rep,2017,7(1):208.
［29］LEE JJ,PARK IH,RHEE WJ,et al.HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress［J］.FASEB J,2019,33(10):10942-10953.
［30］BELTZIG L,CHRISTMANN M,KAINA B,et al.Abrogation of cellular senescence induced by temozolomide in glioblastoma cells:Search for senolytics ［J］.Cells,2022,11(16):2588.
［31］ASHKAN S,SONIA GR,ASHLYN YA,et al.BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer［J］.Cell Death Differ,2020,27(11):3097-3116.
［32］XUE H,BO Z,WEI Z,et al.Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype ［J］.iScience,2021,24(1):102016.
［33］WANG L,YIN H,HUANG S,et al.Bortezomib induces cellular senescence in A549 lung cancer cells by stimulating telomere shortening［J］.Hum Exp Toxicol,2022,41:undefined.
［34］LOUWRENS B,ELISABETH M,SASKIA M,et al.Inhibiting CDK4/6 in breast cancer with palbociclib,ribociclib,and abemaciclib:Similarities and differences［J］.Drugs,2021,81(3):317-331.
［35］LAURA B,JESUS G.Targeting senescence as an anticancer therapy［J］.Mol Oncol,2022,16(21):3855-3880.