|Table of Contents|

The clinical characteristic and treatment of acute leukemia combined with acute appendicitis in children

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 07
Page:
1320-1323
Research Field:
Publishing date:

Info

Title:
The clinical characteristic and treatment of acute leukemia combined with acute appendicitis in children
Author(s):
WANG Xiaojing; HE Yingyi; ZHANG Xiaohong
Department of Hematology and Oncology,Guangzhou Women and Children Medical Center,Guangdong Guangzhou 510000,China.
Keywords:
acute leukemia（AL）; children; acute appendicitis; laparoscopic appendectomy
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2023.07.027
Abstract:
Objective:To analyze the clinical characteristics and treatment of acute appendicitis in children with acute leukemia(AL),and to provide reference for clinical optimization of diagnosis and treatment.Methods：Clinical data of 6 children with AL complicated with acute appendicitis from January 2015 to June 2022 were analyzed retrospectively.All patients followed the China Children's Cancer Group CCCG-ALL-2015 combined regimen.The clinical manifestations,treatment stage,ultrasonic characteristics and treatment methods of patients were analyzed.Finally,the therapeutic effects and outcomes of the patients were compared.Results:According to the time of diagnosis of acute appendicitis,6 cases were numbered as case １ to 6．They were all male,aged between 2~12 years old,with a median age of 6 years.Five patients had type B acute lymphoblastic leukemia (B-ALL) and 1 had mixed phenotypic acute leukemia (T lymphocyte and myeloid phenotype).Acute appendicitis can occur at different stages of chemotherapy,including 4 cases within 45 days after the initial combined chemotherapy,1 case at the interval of chemotherapy,and 1 case at the re-induced stage.The main manifestations of 6 children were fever,right lower abdominal pain,abdominal distension and vomiting,and acute appendicitis was diagnosed by abdominal ultrasound.One patient received simple medical treatment,2 patients received laparoscopic surgery immediately after diagnosis,and 3 patients received laparoscopic treatment after medical conservative treatment failed.Six children with appendicitis were cured,and 5 of them delayed the process of chemotherapy.Conclusion:Acute appendicitis in children with AL often occurs in ALL and occurs in the early stages of combined chemotherapy.Early diagnosis and optimal treatment is important.Early laparoscopic surgery is safe and effective,and combined with supportive treatment in the perioperative period of internal medicine can maximize the benefits of children.

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Last Update: 2023-02-28