|Table of Contents|

Report of 11 cases of acute myeloid leukemia t(16;21)(p11;q22) and review of literatures

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 05
Page:
927-931
Research Field:
Publishing date:

Info

Title:
Report of 11 cases of acute myeloid leukemia t(16;21)(p11;q22) and review of literatures
Author(s):
LIU Wen1; WANG Min1; LAN Shuaiqi2; HU Jieying1
1.Central Laboratory;2.Department of Blood Transfusion,the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital,Henan Zhengzhou 450008,China.
Keywords:
t(16; 21)(p11; q22); TLS/FUS-ERG fusion gene; chromosome translocation; acute myeloid leukemia
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2023.05.027
Abstract:
Objective：To investigate the clinical and laboratory characteristics of 11 acute myeloid leukemia(AML) patients with t(16;21)(p11;q22) translocation.Methods:The clinical and laboratory characteristics of 11 acute myeloid leukemia patients with t(16;21)(p11;q22) in our hospital from July 2007 to March 2022 were analyzed retrospectively and the related literatures were reviewed.Results:All the 11 cases of t(16;21)(p11;q22) translocation were acute myeloid leukemia.According to FAB classification,there were 4 cases of type M2,1 case of type M4,3 cases of type M5 and 3 cases of AML(non-M3),including 5 males and 6 females.Chromosomal R-banding analysis showed t(16;21)(p11;q22) translocation in all 11 cases,of which 9 cases were associated with additional chromosome abnormalities.Fusion gene TLS/FUS-ERG was positive in 9 cases.Except for myeloid CD34,CD117,CD33,CD13 and CD38,all the immunophenotypes expressed CD56.Complete remission was achieved in 7 cases after one cycle of chemotherapy.Conclusion:t(16;21)(p11;q22) translocation is a rare recurrent chromosomal abnormality.This translocation produces TLS/FUS-ERG fusion gene,and immunological tests are often accompanied with positive CD56.M2/M5 type is most common in acute myeloid leukemia.Most of them can be completely relieved in the first cycle of chemotherapy,but it is easy to relapse in a short time and the prognosis is poor.

References:

［1］薛永权.白血病细胞遗传学理论方法与图谱［M］.天津:天津科学技术出版社,2003：61-65. XUE YQ.Theory,method and map of cytogenetics of leukemia［M］.Tianjin：Tianjin Science and Technology Publishing House,2003：61-65.
［2］JEKARL DW,KIM M,LIM J,et al.CD56 antigen expression and hemophagocytosis of leukemic cells in acute myeloid leukemia with t（16；21)（p11；q22) ［J］.Int J Hematol,2010,92(2)：306-313.
［3］欧阳敏,许兰平,王昱,等.t(16;21)(p11;q22)急性髓系白血病九例报告并文献复习［J］.中华血液学杂志,2016,37(3):210-215. OUYANG M,XU LP,WANG Y,et al.Clinical characteristics of acute myeloid leukemia with t（16;21)（p11;q22):nine cases report and literature review［J］.Chinese Journal of Hematology,2016，37（3):210-215.
［4］谭丽,谭获,刘文丹,等.伴t(16;21)(p11;q22)的恶性血液病的临床和实验分析［J］.检验医学与临床,2011,8(20):2440-2441. TAN L,TAN H,LIU WD,et al.Clinical and experimental analysis of malignant hematological diseases with t(16;21)(p11;q22)［J］.Laboratory Medicine and Clinic,2011,8(20):2440-2441.
［5］吴亚芳,薛永权,潘金兰,等.5例伴有t(16;21)(p11;q22)急性白血病的临床和实验研究［J］.中华医学遗传学杂志,2003,20(2):171-173. WU YF,XUE YQ,PAN JL,et al.Clinical and experimental study of 5 cases of acute leukemia with t(16;21)(p11;q22)［J］.Chinese Journal of Medical Genetics,2003,20(2):171-173.
［6］裴荣荣,张荣辉,孙玲.TLS-ERG融合基因阳性的成年人急性髓系白血病二例并文献复习［J］.白血病?淋巴瘤,2019,28(11):668-671. PEI RR,ZHANG RH,SUN L.Adult acute myeloid leukemia with positive TLS-ERG fusion gene：a report of 2 cases and literature review［J］.Leukemia?Lymphoma,2019,28(11):668-671.
［7］BUCHANAN J,TIRADO CA.A t(16;21)(p11;q22) in acute myeloid leukemia（AML) resulting in fusion of the FUS/TLS and ERG genes：A review of the literature［J］.Journal of the Association of Genetic Technologists,2016,42（1):24-33.
［8］SHIKAMI M,MIWA H,NISHI K,et al.Myeloid differentiation antigen and cytokine receptor expression on acute myeloid leukemia cells with t(16;21)（p11;q22)：frequent expression of CD56 and interleukin-2 receptor alpha chain［J］.Br J Haematol,1999,105:711-719.
［9］王朝荣,王亚峰,刘炜,等.伴有TLS-ERG融合基因阳性儿童急性白血病临床分析［J］.中国现代医药杂志,2020,22(12):41-45. WANG CR,WANG YF,LIU W,et al.Clinical analysis of acute leukemia in children with positive TLS-ERG fusion gene［J］.Chinese Journal of Modern Medicine,2020,22(12):41-45.
［10］刘晓红.白血病干细胞相关抗原在急性髓系白血病表达的相关性研究［D］.石家庄：河北医科大学,2018. LIU XH.Study on the expression of leukemia stem cell associated antigen in acute myeloid leukemia［D］.Shijiazhuang:Hebei Medical University,2018.
［11］窦留瑞,魏圣洁,李丹,等.CD15在急性髓系白血病患者中表达及其临床意义［J］.中华实用诊断与治疗杂志,2022,36(4):370-373. DOU LR,WEI SJ,LI D,et al.Expression of CD15 in patients with acute myeloid leukemia and its clinical significance［J］.Chinese Journal of Practical Diagnosis and Treatment,2022,36(4):370-373.
［12］赵宗晨,张之芬,刘义庆,等.伴t(16;21)(p11;q22)急性髓系白血病二例并文献复习［J］.白血病?淋巴瘤,2014,23(9):546-548,552. ZHAO ZC,ZHANG ZF,LIU YQ,et al.Two cases of acute myeloid leukemia with t(16;21)(p11;q22) and review of literature［J］.Leukemia?Lymphoma,2014,23(9):546-548,552.
［13］胡冠华,陆爱东,贾月萍,等.TLS/ERG阳性儿童急性髓系白血病临床特点及预后［J］.临床儿科杂志,2020,38(12):930-935. HU GH,LU AD,JIA YP,et al.Clinical characteristics and prognosis of TLS/ERG positive children with acute myeloid leukemia［J］.Journal of Clinical Pediatrics,2020,38(12):930-935.
［14］郭睿,沈安俐,王琰,等.CD56阳性急性髓系白血病患者的免疫表型分析［J］.中国实验血液学杂志,2015,23(5):1231-1234. GUO R,SHEN AL,WANG Y,et al.Analysis of immunophenotype in patients with CD56 positive acute myeloid leukemia［J］.Chinese Journal of Experimental Hematology,2015,23(5):1231-1234.
［15］刘莎,魏旭东,米瑞华,等.CD56在t(8;21)成人急性髓系白血病患者中的表达及其与预后的相关性分析［J］.中华血液学杂志,2015,36(8):676-681. LIU S,WEI XD,MI RH,et al.Expression of CD56 in t(8;21) adult acute myeloid leukemia and its correlation with prognosis［J］.Chinese Journal of Hematology,2015,36(8):676-681.
［16］伦韦丹,项卫卫,卢玲,等.急性髓系白血病(AML)患者白血病细胞CD56抗原表达与预后的关系［J］.当代医学,2018,24(32):128-130. LUN WD,XIANG WW,LU L,et al.Relationship between CD56 antigen expression and prognosis in patients with acute myeloid leukemia（AML)［J］.Contemporary Medicine,2018,24(32):128-130.
［17］罗绿艳.CD123、CD56和CD7在急性髓系白血病中的表达及其临床意义［D］.南昌：南昌大学,2020. LUO LY.Expression and clinical significance of CD123,CD56 and CD7 in acute myeloid leukemia［D］.Nanchang:Nanchang University,2020.
［18］CHANG WR,PARK IJ,LEE HW,et al.Two cases of acute myeloid leukemia with t(16;21)(p11;q22) and TLS/FUS-ERG fusion transcripts［J］.Korean Journal of Laboratory Medicine,2009,29（5):390-395.
［19］MANABE M,YOSHII Y,MUKAI S,et al.Transient efficacy of cord blood transplantation in acute myeloid leukemia with t（16;21)（p11;q22) ［J］.Asia Pac J Clin Oncol,2011,7(3):315-316.
［20］TODA Y,NAGAI Y,SHIMOMURA D,et al.Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene［J］.Clinical Case Reports,2017,5(12):1938-1944.

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Last Update: 2023-01-31