|Table of Contents|

Evaluation of left atrial function in breast cancer patients treated with anthracycline by real-time three-dimensional echocardiography combined with velocity vector imaging

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 05
Page:
916-921
Research Field:
Publishing date:

Info

Title:
Evaluation of left atrial function in breast cancer patients treated with anthracycline by real-time three-dimensional echocardiography combined with velocity vector imaging
Author(s):
LIU Jie; PENG Xuelian; LIANG Shan; ZHAO Xiangzhi
Department of Heart Ultrasound，Affiliated Hospital of Southwest Medical University，Sichuan Luzhou 646000，China.
Keywords:
echocardiography; real-time three-dimensional; velocity vector imaging technology; breast cancer; left atrium; anthracycline
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2023.05.025
Abstract:
Objective：To evaluate the left atrial function of breast cancer patients with anthracycline（ATC) chemotherapy by real-time three-dimensional echocardiography（RT-3DE) and velocity vector imaging（VVI).Methods:72 female breast cancer patients who underwent ATC chemotherapy in our hospital were enrolled.Echocardiographic parameters were collected at three stages,including before chemotherapy,3 cycles of chemotherapy（during chemotherapy) and 6 cycles of chemotherapy（after chemotherapy).Left atrial end-diastolic volume（LAVmax),left atrial pre-systolic volume（LAVprep) and left atrial end-systolic volume（LAVmin) were obtained by RT-3DE imaging.Left atrial active ejection fraction（LAAEF) and left atrial total ejection fraction（LATEF) were calculated.The peak systolic strain（Ss) and strain rate（s-SR) of left atrium and peak diastolic strain（Sa) and strain rate（a-SR) of left atrium were obtained by four cavity heart apex 2D image.Results:LAVmax,LAVprep and LAVmin increased after chemotherapy compared with during chemotherapy（P<0.05).LAAEF and LATEF were lower after chemotherapy than before and during chemotherapy（P<0.05).Compared with before chemotherapy,Ss,s-SR and a-SR decreased in during chemotherapy and after chemotherapy,and Ss,s-SR and a-SR also decreased after chemotherapy compared with during chemotherapy（P<0.05).There was no significant difference in Sa among the three stages（P>0.05).Conclusion:ATC chemotherapy can reduce the function of left atrial storage and pump in breast cancer patients,and the damage is more serious in the later stage of chemotherapy.RT-3DE and VVI can sensitively detect the changes of left atrial function in breast cancer patients after chemotherapy from different angles,providing good application value for early clinical detection and timely change of treatment plan.

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Last Update: 2023-01-31