|Table of Contents|

Clinical prognosis and related factors of 91 children with medulloblastoma after postoperative radiotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 05
Page:
839-842
Research Field:
Publishing date:

Info

Title:
Clinical prognosis and related factors of 91 children with medulloblastoma after postoperative radiotherapy
Author(s):
YANG Hui; SONG Linan; NI Wenjie; LIU Xiaolei; HOU Dongliang
Department of Radiotherapy,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China.
Keywords:
children; medulloblastoma; radiotherapy; prognostic inflence factor
PACS:
R730.264
DOI:
10.3969/j.issn.1672-4992.2023.05.010
Abstract:
Objective:To evaluate the clinical prognosis and related factors of children medulloblastoma(MB)after postoperative radiotherapy.Methods:91 children with MB treated in our hospital from January 2011 to December 2015 were analyzed retrospectively.Gender,age,tumor location,degree of surgical resection,M stage before radiotherapy,risk-grouping,dose of radiotherapy,radiotherapy target,postoperative chemotherapy or not,and radiotherapy-surgery interval were analyzed.Kaplan-Meier method was used for survival analysis,log rank test was used for univariate analysis,and Cox regression model was used for multivariate analysis.Results:In this group,9 patients were lost and the loss rate was 9.9%,the other 82 patients were followed up for 5 years or died.During the follow-up periods,25 patients had local recurrence or metastasis,of which 16 patients died after treatment,9 patients survived with tumor.The 3,5-year progression free survival(PFS) rates were 79.3%,70.8%and the 3,5-year overall survival(OS) rates were 84.9%,81.3% respectively.The 5-year PFS and OS of 63 patients in the average-risk group were 77.5% and 89.6%,of which 11 patients were treated with reduced-dose craniospinal irradiation,and the 5-year OS was 76.2%.On univariate analysis,the degree of surgical resection,M stage and risk-grouping affected PFS(P=0.015,P=0.004,P=0.016) and OS(P=0.009,P=0.001,P=0.002),with significantly differences.Cox regression multivariate analysis showed that M stage was an independent prognostic factor affecting PFS(P=0.007) and OS(P=0.002).Conclusion:The degree of surgical resection,M stage before radiotherapy and risk-grouping were high risk factors for poor prognosis in children with MB and M stage was an independent prognostic factor for poor prognosis.Reducing dose and volume of radiotherapy without compromising the prognosis is the focus in this field.

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Last Update: 2023-01-31