|Table of Contents|

Comparative analysis of clinicopathological features of bronchiolar adenoma with proximal type and distal type (4 cases)

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 04
Page:
675-680
Research Field:
Publishing date:

Info

Title:
Comparative analysis of clinicopathological features of bronchiolar adenoma with proximal type and distal type (4 cases)
Author(s):
YANG Chunmei; DENG Wei
Department of Pathology,Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine，Jiangsu Kunshan 215300,China.
Keywords:
bronchiolar adenoma; proximal type; distal type; pathology; immunohistochemistry; differential diagnosis
PACS:
R734.1
DOI:
10.3969/j.issn.1672-4992.2023.04.015
Abstract:
Objective:To investigate the clinicopathological features,diagnosis and differential diagnosis of two types of bronchiolar adenoma. Methods:Four cases of BA treated in our hospital from March 2018 to April 2021 were collected,and their clinical data,imaging examination,histopathological features,immunohistochemical phenotype and differential diagnosis were analyzed.Results:Among the patients,there were 2 males and 2 females,1 had a history of smoking and 2 had no clinical symptoms.The imaging findings were ground glass or well-defined nodules.Generally,there are gray and gray brown solid nodules or local microcapsules,most of which are clear with no capsule,and the maximum diameter is 0.6~1.2 cm.Cases 1 and 2 showed double-layer papillary structure under microscope.The inner layer was rich in ciliated cells and mucus cells,expressing CK7,Napsin-A,CEA and MUC5AC,weakly expressing TTF-1,and the outer layer was basal cells,expressing p40 and CK5/6.It was diagnosed as proximal BA.Cases 3 and 4 showed double-layer glandular cavity structure under microscope.The inner layer was composed of type II alveolar epithelium and Clara cells,lacking cilia and mucus cells,expressing CK7,Napsin-A,TTF-1,weak CEA and MUC5AC,and the outer layer was composed of basal cells,expressing p40 and CK5/6.It was diagnosed as distal BA.Conclusion:Bronchiolar adenoma (BA) is a benign tumor with double-layer structure.It is easy to be misdiagnosed as malignant in imaging examination and rapid frozen section.According to the proportion of mucous cells and ciliated cells in luminal cells,bronchiolar adenomas were divided into proximal and distal types.

References:

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