|Table of Contents|

Effect of continuous intravenous lidocaine on postoperative recovery of intestinal function and delirium in elderly patients undergoing colorectal tumor surgery

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 03
Page:
481-484
Research Field:
Publishing date:

Info

Title:
Effect of continuous intravenous lidocaine on postoperative recovery of intestinal function and delirium in elderly patients undergoing colorectal tumor surgery
Author(s):
CHEN Hongsheng1; SHEN Ying1; DING Weifeng2
1.Department of Anesthesiology;2.Department of Laboratory Medicine,Affiliated Hospital of Nantong University,Jiangsu Nantong 226001,China.
Keywords:
colorectal neoplasms; elderly patient; lidocaine; postoperative delirium
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2023.03.017
Abstract:
Objective:To investigate the effect of continuous intravenous lidocaine on postoperative delirium(POD) in elderly patients undergoing colorectal tumor surgery.Methods:60 elderly patients who underwent colorectal tumor surgery from May 2020 to June 2021 in our hospital were randomly divided into 2 groups,lidocaine group(Group L,n=30) and normal saline group(Group C,n=30).In group L,1% lidocaine 1.5 mg/kg(0.15 mL/kg) was slowly administ rated by a intravenous bolus 10 min before induction of anesthesia,and the medication lasted for about 10 min.The micro pump was used to continue infusion of 1% lidocaine 0.15 mL/(kg·h) continues intravenous pumping to the end of the suture.Group C received intravenous medication with equal volume of normal saline before induction and during the maintenance of anesthesia.Anesthesia was performed after the medication,and an intravenous analgesic pump was connected for postoperative analgesia.Record the time of the patient's first bowel movement,pain was scored on the first and second day after the operation by the numerical pain score(NRS).The simple mental state evaluation scale(MMSE) method was used to evaluate POD on the first day before operation,the fisrt day after operation,and the 3th day after operation.Results:There was no significant difference under the general conditions between the two groups before the operation,and no local anesthetic poisoning occurred.After the operation,the first defecation time of the group L was significantly earlier than that of the group C(P<0.05).On the first postoperative day,the number of PCIA pump compressions was significantly higher in the group C(7.5±2.8 times) than that in the group L(2.8±1.1 times)(P<0.05).The MMSE score of the group L was significantly higher than that of group C on the 1st and 3rd day after operation(P<0.05).Compared with the MMSE score of the first day before operation,group C on the 1st and 3rd day after operation MMSE decreased significantly(P<0.05).There was no significant difference in the scores of patients among the group L(P>0.05).The incidence of POD in the group C was significantly higher than that in the group L on the 1st and 3rd day after operation(P<0.05).Conclusion:Continuous intravenous lidocaine can decrease the incidence of postoperative delirium in the elderly patients undergoing colorectal tumor surgery and promote the recovery of the intestinal function.

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Memo

Memo:
江苏省卫健委自然科学基金（编号：M2020065）;江苏省南通市卫生健康委员会科研课题资助（编号：MA2021008）
Last Update: 2022-12-30