«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 03

Page:

469-472

Research Field:

Publishing date:

Info

Title:

Clinicopathological features analysis of bronchiolar adenoma（five cases）

Author(s):

JIA Baolong; WANG Liqiong; ZHU Huirong

Department of Pathology,Kunming Yan'an Hospital,Yunnan Kunming 650500，China.

Keywords:

lung tumor; bronchiolar adenoma; immunohistochemistry

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2023.03.014

Abstract:

Objective:To study the clinicopathological features,diagnosis and prognosis of bronchiolar adenoma (BA).Methods:Five cases of BA were collected in our hospital,from 2019 to 2020.The clinicopathological features,diagnosis and prognosis were summarized,and the literature was reviewed.Results:The age range of the five patients was 56~73 years old,and the median age was 62 years old.There were 3 males and 2 females.Three patients had smoking history.Four patients had no clinical symptoms,and small pulmonary nodules were found on CT during physical examination.The section shows grayish white and grayish brown solid or cystic changes,with clear boundary but no capsule,and the maximum diameter is 0.4~1.2 cm.The main body of the tumor is located in the lung parenchyma outside the bronchioles,with clear boundaries but no capsule,showing papillary,flat or adenoid growth.The most prominent histological feature was the double-layer cell structure composed of continuous p63,p40,CK5/6 positive basal cells and luminal cells,while luminal cells were composed of mucous cells and ciliated cells.After 18~30 months of follow-up,no recurrence or metastasis was found in all patients.Conclusion:BA is a benign tumor located in the periphery of the lung.Intraoperative frozen diagnosis is very critical for surgical treatment,and the diagnosis is also very difficult.If necessary,immunohistochemical staining should be done for differential diagnosis.Moreover,patients with multiple lesions are easy to be misdiagnosed as malignant.BA has continuous p63,p40,CK5/6 positive basal cell layer,which can be distinguished from other malignant tumors.Surgical resection is the first choice of treatment.The prognosis of patients after operation is good,and patients have no recurrence or metastasis.

References:

[1]CHANG JC,MONTE CA LVO J,BORSU L,et al.Bronchiolar adenoma:Expansion of the concept of ciliated muconodular papillary tumors with proposal for revised terminology based on morphologic,immunophenotypic,and genomic analysis of 25 cases［J］.American Journal of Surgical Pathology,2018,42(8):1010-1026.
[2] WANG EH.Bronchiolar adenoma:a benign tumor easily confused with cancer ［J］ .Chinese Journal of Pathology,2019,48(6):8.
[3]YOSHINOBU H,RENA Y,FUMITOMO S,et al.Ciliated muconodular papillary tumor of the lung:A newly defined low-grade malignant tumor with CT findings reminiscent of adenocarcinoma［J］.Japanese Journal of Clinical Oncology,2013(2):205-207.
[4] CHUANG HW,LIAO JB,CHANG HC,et al.Ciliated muconodular papillary tumor of the lung:a newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma:a case report and review of literature［J］.Pathology International,2014,64(7):352-357.
[5]WANG XL,DA JP.The concept,diagnosis and biological behavior of ciliated mucinous nodular papillary tumor/bronchiolar adenoma ［J］.Journal of Clinical and Experimental Pathology,2020,36(9):5.
[6] UDO E,FURUSATO B,SAKAI K,et al.Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation［J］.Diagnostic Pathology,2017,12(1):62.
[7] TOSHIAKI K,KOJI O,MAI MA,et al.Molecular pathological study of four cases of ciliated muconodular papillary tumors of the lung［J］.Pathology International,2018,68(6):353-358.
[8]WEI JG,LIU Y.Pulmonary ciliated mucinous nodular papillary tumors in Western patients have BRAF and AKT1 mutations ［J］.Journal of Clinical and Experimental Pathology,2017,33(1):1.
[9] KAO TH,YEH YC.Ciliated muconodular papillary tumor/bronchiolar adenoma of the lung［J］.Seminars in Diagnostic Pathology,2021,38(5):62-71.
[10] ZHANG J,SHAO PC,HAN YC,et al.Some problems in pathological diagnosis of bronchiolar adenoma ［J］.Chinese Journal of Pathology,2020,49(06):529-533.
[11] KAH WENG LAU,MARIE-CHRISTINE AUBRY,GEK SAN TAN,et al.Ciliated muconodular papillary tumor:a solitary peripheral lung nodule in a teenage girl［J］.Human Pathology,2016,49:22-26.
[12] MASASHI I,SHINICHI S,NAOTO I,et al.Ciliated muconodular papillary tumor of the lung:report of five cases［J］.Journal of Surgical Case Reports,2016,8:1-4.
[13] LI X,WU Y,HUI D,et al.Multiple bronchiolar adenomas with malignant transformation and CCNE1 mutation:a case report and literature review［J］.Cardiothorac Surg,2021,16(1):307.
[14] QIU Y,ZHANG NC,LIU LL,et al.Clinicopathological observation of 12 cases of pulmonary bronchiolar adenoma ［J］ .Chinese Journal of Pathology,2021,50(8):3.
[15] GAO H,DU XL,CHEN CN,et al.Clinicopathological observation of 15 cases of bronchiolar adenoma ［J］.Chinese Journal of Pathology,2020,49(06):556-561.

Memo

Memo:

-

Common functions

Last Update: 2022-12-30