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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 02

Page:

363-366

Research Field:

Publishing date:

Info

Title:

Research progress of M1 macrophages in the tumor microenvironment of colorectal cancer

Author(s):

LYU Fenghong; GUO Jiasen; HUANG Youguang

The Third Affiliated Hospital of Kunming Medical University,Yunnan Kunming 650100,China.

Keywords:

colorectal cancer; MSI-H colorectal cancer; tumor microenvironment; M1 macrophages

PACS:

R735.3+7

DOI:

10.3969/j.issn.1672-4992.2023.02.033

Abstract:

There are many types of immune cells in the tumor microenvironment of colorectal cancer,among which tumor-associated macrophages£¬as an important component,can be polarized into M1 and M2 subtypes.M1 macrophages mainly play an inhibitory role in tumor development,while M2 macrophages play a role in promoting cancer.MSI-H colorectal cancer tumor microenvironment has significantly higher M1 macrophages than MSS.Immunotherapy effect is better.This paper mainly reviews the role of M1 macrophages in colorectal cancer,in order to provide more theoretical basis and new ideas for MSI-H colorectal cancer immunotherapy.

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Memo

Memo:

National Natural Science Foundation of China(No.81660417);¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÏîÄ¿£¨±àºÅ£º81660417£©

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