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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 02

Page:

327-331

Research Field:

Publishing date:

Info

Title:

Clinicopathological and molecular pathological analysis of 6 cases of retroperitoneal synovial sarcoma

Author(s):

ZHANG Xiaoying; LI Chunmei; ZHU Xiaoyun; REN Yubo; WANG Lihua

Department of Pathology£¬Peking University International Hospital£¬Beijing 102206,China.

Keywords:

synovial sarcoma; retroperitoneal; immunohistochemistry; molecular pathology

PACS:

R738.5

DOI:

10.3969/j.issn.1672-4992.2023.02.025

Abstract:

Objective:To investigate the clinicopathological features,immunophenotype and molecular genetic changes of retroperitoneal synovial sarcoma.Methods:The retroperitoneal specimens from the department of pathology of Peking University International Hospital from December 2014 to July 2021 were collected,and 6 cases of synovial sarcoma were pathologically diagnosed.Light microscopic observation,immunophenotypic and molecular pathological analysis were performed,and the relevant literature was reviewed.Results:There were 2 males and 4 females,aged from 12 to 56 years old(mean age 29 years old,median age 26 years old).The tumor size was 8~20 cm,with an average of 15.2 cm.The boundary was clear.There were 5 cases of spindle cell type and 1 case of biphasic type.The positive rates of Ckpan,EMA,Bcl-2,CD99,TLE1,Vimentin,CD34 and Calponin were 5/6,6/6,6/6,3/6,6/6,5/6,0/6 and 4/6 respectively.INI1 was expressed in a special pattern 6/6.Ki-67 was highly expressed.FISH results showed that 6 cases had SS18-SSX gene fusion;Three cases were SS18-SSX2 gene fusion with concomitant gene mutation.Conclusion:Retroperitoneal synovial sarcoma is a rare site.The definite diagnosis often needs to be combined with histopathological morphology,immunohistochemical expression and molecular genetic characteristics.

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