|Table of Contents|

Expression and significance of ferroptosis related proteins SLC7A11 and GPX4 in renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 02
Page:
323-326
Research Field:
Publishing date:

Info

Title:
Expression and significance of ferroptosis related proteins SLC7A11 and GPX4 in renal cell carcinoma
Author(s):
REN Zongtao; MA Yongliang; WEI Shufei; QI Pan; ZHANG Aili
Department of Urology,the Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang 050011,China.
Keywords:
renal cell carcinoma; ferroptosis; SLC7A11; GPX4; prognosis
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2023.02.024
Abstract:
Objective:To investigate the differences in the expression of SLC7A11 and GPX4 in renal cell carcinoma and normal renal tissues,and to preliminarily analyze the relationship between the expression of SLC7A11 and GPX4 and the prognosis of renal cell carcinoma.Methods:The expression level of SLC7A11 and GPX4 in renal cell carcinoma and normal renal tissues were detected by immunohistochemistry,the correlation between the level of SLC7A11 and GPX4 and clinicopathological parameters of patients was analyzed.Spearman method was used to analyze the correlation between SLC7A11 and GPX4 expression,Kaplan-Meier survival curve and Cox regression were used to analyze the influence of the level of SLC7A11,GPX4 expression and clinical-pathological features on the prognosis of renal carcinoma patients.Results:SLC7A11 and GPX4 were highly expressed in renal cell carcinoma,while,were low expressed in normal renal tissue（P<0.05）.In addition,the expression of SLC7A11 and GPX4 were closely related to tumor diameter,distant metastasis and the clinical stage of renal cell carcinoma.Further analysis showed that SLC7A11 and GPX4 were positively correlated(r=0.583，P<0.01).In renal cell carcinoma tissues,patients with positive SLC7A11 and GPX4 expression had a poorer prognosis than those with negative expression （P<0.05）.Multivariate analysis indicated that tumor diameter,distant metastasis,clinical stage,SLC7A11 and GPX4 were independent prognosis factors.Conclusion:SLC7A11 and GPX4 are highly expressed in renal cell carcinoma,which may be involved in the occurrence of renal cell carcinoma.Patients with renal cell carcinoma with high SLC7A11 and GPX4 expression have a poor prognosis.

References:

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