|Table of Contents|

The value of level detection of carcinoembryonic antigen combined with fasting plasma glucose for evaluating the prognosis of advanced gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 02
Page:
282-286
Research Field:
Publishing date:

Info

Title:
The value of level detection of carcinoembryonic antigen combined with fasting plasma glucose for evaluating the prognosis of advanced gastric cancer
Author(s):
YIN Wenbo; WANG Zian
Department of Oncology,the First Affiliated Hospital of Bengbu Medical College,Anhui Bengbu 233000,China.
Keywords:
carcinoembryonic antigen; fasting plasma glucose; advanced gastric cancer; prognosis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2023.02.016
Abstract:
Objective:To study the value of combined level detection of carcinoembryonic antigen (CEA) and fasting plasma glucose (FPG) in evaluating the prognosis of advanced gastric cancer.Methods:The clinical data of 300 patients with advanced gastric cancer who received chemotherapy in our hospital were analyzed retrospectively.The demographic,hematological,pathological and imaging data were collected before chemotherapy,and the 2-year survival time was followed up.The best critical value of CEA and FPG was determined by ROC curve.The survival curves of patients in different groups were compared by Kaplan-Meier analysis.Multivariate COX risk regression model was used to analyze the correlation between CEA,FPG and prognosis.Results:The best critical values for evaluating the prognosis of gastric cancer in CEA and FPG were 5.865 mg/mL and 6.845 mmol/L.Log-rank test showed that there was a significant correlation between CEA,FPG and overall survival (OS)(CEA group:P=0.000.FPG group:P=0.000).The 2-year survival rate was 67.9% in the low CEA and low FPG group,16.9% in the low CEA and high FPG group,26.4% in the high CEA and low FPG group,and 6.9% in the high CEA and high FPG group.The difference in survival rate among groups was statistically significant （P=0.00）.COX regression analysis showed that gender,TNM stage,degree of differentiation,CEA level,FPG level,smoking history and operation were the risk factors affecting the prognosis of the patients (HR=0.717,HR=0.162,HR=0.591,HR=1.006,HR=1.097,HR=0.421,HR=2.504,P＜0.05).Conclusion:The combined level detection of CEA and FPG has a certain clinical value in evaluating the prognosis of advanced gastric cancer patients.

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Memo

Memo:
安徽省教育厅重点课题（编号：KJ2017A238）；蚌埠医学院研究生创新计划项目（编号：Byycxz20046）
Last Update: 1900-01-01