|Table of Contents|

Excess visceral fat increases the risk of anastomotic leakage after rectal cancer surgery：A paired case-control study

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 02
Page:
277-282
Research Field:
Publishing date:

Info

Title:
Excess visceral fat increases the risk of anastomotic leakage after rectal cancer surgery：A paired case-control study
Author(s):
WU Kaiqiang; ZHANG Wei; ZHU Yuanzeng; WU Gang; SUN Peichun
Department of Gastrointestinal Surgery,Zhengzhou University People's Hospital (Henan Provincial People's Hospital),Henan Zhengzhou 450003,China.
Keywords:
rectal cancer; anastomotic leakage; risk factors; visceral fat area
PACS:
R735.3+7
DOI:
10.3969/j.issn.1672-4992.2023.02.015
Abstract:
Objective:To investigate the association between visceral fat level and anastomotic leakage formation after rectal cancer surgery.Methods:A retrospective analysis was performed on 51 patients with rectal cancer who underwent anterior rectal resection and developed postoperative anastomotic leakage in our hospital from September 2014 to May 2021.A paired case-control design was used to select 102 patients who underwent anterior rectal resection at the same time and by the same group of surgeons in a sample size of 1∶2,using the patients' age,tumor TNM stage,ASA classification,family history of rectal cancer,and history of diabetes as screening factors.The differences in gender,visceral fat area (VFA),visceral fat area/subcutaneous fat area (V/S),body mass index (BMI),the history of preoperative neoadjuvant chemoradiotherapy,duration of surgery,intraoperative bleeding,tumor diameter,and distance from the anal verge were compared between the two groups.Results:A total of 153 samples were included,including 51 samples from the anastomotic leakage group and 102 samples from the control group.Univariate analysis showed that the occurrence of postoperative anastomotic leakage in rectal cancer was associated with gender,VFA,V/S,history of preoperative neoadjuvant radiotherapy,intraoperative bleeding,distance from the anal verge,tumor diameter (P＜0.05).Multivariate Logistic regression analysis of these factors revealed that VFA,V/S,history of preoperative neoadjuvant radiotherapy,distance from the anal verge,tumor diameter,and intraoperative bleeding were independent risk factors for anastomotic leakage after rectal cancer surgery (P＜0.05).Conclusion:VFA can be an independent risk factor for postoperative anastomotic leakage in rectal cancer.For patients with visceral obesity,active interventions should be made during the perioperative period to reasonably regulate the underlying disease and nutritional status and strengthen perioperative management to reduce the occurrence of postoperative anastomotic leakage.

References:

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河南省医学科技攻关计划联合共建项目（编号：2018020433）
Last Update: 1900-01-01