|Table of Contents|

LNM risk assessment of DTC patients based on a constructed nomogram model

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 02
Page:
248-252
Research Field:
Publishing date:

Info

Title:
LNM risk assessment of DTC patients based on a constructed nomogram model
Author(s):
WANG Junyan1; 2; YUAN Menghui2; LI Yunbo2; WEI Guangming2; HE Wei2; GAO Liuyan2; YANG Aimin1
1.Department of Nuclear Medicine,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China；2.Department of Nuclear Medicine,the Second Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710038,China.
Keywords:
differentiated thyroid cancer; lymph node metastasis; nomogram
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2023.02.009
Abstract:
Objective:In order to determine the first treatment dose of 131I after differentiated thyroid carcinoma (DTC) postoperation,a nomogram model was established to explore the independent predictors of lymphatic node metastasis (LNM) in DTC.Methods:332 DTC patients data,with whole thyroid resected and lymphatic node clearance operation in Tangdu Hospital from January 2020 to January 2022,were divided into metastasis-free group (M0) and cervical lymph node metastasis group (M1),according to the results of systemic imaging (Rx-WBS) and SPECT/CT fusion imaging after thyroid 131I treatment.The possible related indicators including gender,age,tumor diameter,capsule invasion,tumor N stage and platelet count (P),neutrophil count (N),lymphocyte count (L),preablative stimulated Tg (ps-Tg)and thyroid stimulating hormone (TSH) were concluded.Logistic multivariate analysis was used to determine the independent predictors of LNM after DTC postoperation.A nomogram model was developed by R3.6.1 to integrate all predictors based on multivariate analysis,evaluated according to the receiver operating characteristic curve,and then validated by the bootstrap calibration method.Results:The results of multivariate analysis showed that gender (P＜0.001),age (P=0.044),ps-Tg (P＜0.001),capsule invasion (P＜0.001),and L count (P=0.028) were independent predictors of LNM respectively.The AUC of the nomogram model integrating the above five factors achieved 0.713 (95%CI 0.706~0.720).And the model prediction of LNM risk was consistent within the actual incidence,with prediction errors less than 10%.Conclusion:Gender,age,ps-Tg,capsule invasion,and L count were independent predictors of LNM after DTC operation.The nomogram prediction model based on the multi-indicators is capable to guide personalized 131I treatment after DTC operation.

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Memo

Memo:
National Natural Science Foundation of China(No.81871389);国家自然科学基金面上项目（编号：81871389）
Last Update: 1900-01-01