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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2022 06

Page:

1129-1133

Research Field:

Publishing date:

Info

Title:

Research advances of vitamin D and its receptor in gynecologic cancer

Author(s):

YIN Junyang; YE Yuan

Department of Gynaecology,Affiliated Hospital of Guilin Medical University,Guangxi Guilin 541001,China.

Keywords:

vitamin D; VDR; ovarian cancer; cervical cancer; endometrial carcinoma; vulvar cancer; vaginal cancer

PACS:

R737.3

DOI:

10.3969/j.issn.1672-4992.2022.06.038

Abstract:

In the past two decades,many studies have been concerned with the regulation mechanism of vitamin D and vitamin D receptor(VDR) in cancer.The 1,25(OH)2D3 is an active metabolite of vitamin D.It can not only maintain mineral homeostasis and bone dynamic balance,but also inhibit cell proliferation,induce cell differentiation,apoptosis and immune regulation.In recent years,more and more research evidence shows that vitamin D and VDR play an important role in the pathogenesis of gynecological cancer.It is a new entry point in the study of gynecological cancer treatment.In this paper,the status of vitamin D and its receptors in gynecological malignancies will be reviewed.

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