［1］ZHONG H,TANG HF,KAI Y.N6-methyladenine RNA modification(m6A):An emerging regulator of metabolic diseases［J］.Curr Drug Targets,2020,21(11):1056-1067.
［2］LIU ZX,LI LM,SUN HL,et al.Link between m6A modification and cancers［J］.Front Bioeng Biotechnol,2018,6:89.
［3］GAN H,HONG L,YANG F,et al.Progress in epigenetic modification of mRNA and the function of m6A modification［J］.Chin J Biotechnol,2019,35(5):775-783.
［4］LIU J,YUE Y,HAN D,et al.A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation［J］.Nat Chem Biol,2014,10(2):93-95.
［5］ZHAO X,YANG Y,SUN BF,et al.FTO and obesity:mechanisms of association［J］.Curr Diab Rep,2014,14(5):486.
［6］WANG Y,LU JH,WU QN,et al.LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer［J］.Mol Cancer,2019,18(1):174.
［7］LASMAN L,KRUPALNIK V,VIUKOV S,et al.Context-dependent functional compensation between Ythdf m6A reader proteins［J］.Genes Dev,2020,34(19-20):1373-1391.
［8］DU H,ZHAO Y,HE J,et al.YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex［J］.Nat Commun,2016,7:12626.
［9］HOU H,ZHAO H,YU X,et al.METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway［J］.Pathol Res Pract,2020,216(9):153087.
［10］YANG N,YING P,TIAN J,et al.Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population［J］.Carcinogenesis,2020,41(6):761-768.
［11］LIU S,HUANG M,CHEN Z,et al.FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13［J］.Exp Cell Res,2020,389(1):111894.
［12］GOBIN E,BAGWELL K,WAGNER J,et al.A pan-cancer perspective of matrix metalloproteases(MMP) gene expression profile and their diagnostic/prognostic potential［J］.BMC Cancer,2019,19(1):581.
［13］WU S,ZHANG L,DENG J,et al.A novel micropeptide encoded by Y-linked LINC00278 links cigarette smoking and AR signaling in male esophageal squamous cell carcinoma［J］.Cancer Res,2020,80(13):2790-2803.
［14］ZHANG B,WU Q,LI B,et al.m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer［J］.Mol Cancer,2020,19(1):53.
［15］ZHANG C,ZHANG M,GE S,et al.Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer［J］.Cancer Med,2019,8(10):4766-4781.
［16］HE X,SHU Y.RNA N6-methyladenosine modification participates in miR-660/E2F3 axis-mediated inhibition of cell proliferation in gastric cancer［J］.Pathol Res Pract,2019,215(6):152393.
［17］LIU T,YANG S,SUI J,et al.Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer［J］.J Cell Physiol,2020,235(1):548-562.
［18］WANG Q,CHEN C,DING Q,et al.METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance［J］.Gut,2020,69(7):1193-1205.
［19］YUE B,SONG C,YANG L,et al.METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer［J］.Mol Cancer,2019,18(1):142.
［20］LIU X,XIAO M,ZHANG L,et al.The m6A methyltransferase METTL14 inhibits the proliferation,migration,and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway［J］.J Clin Lab Anal,2021,35(3):e23655.
［21］YU H,ZHAO K,ZENG H,et al.N(6)-methyladenosine(m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability［J］.Biomed Pharmacother,2021,133:111075.
［22］ZHANG J,GUO S,PIAO HY,et al.ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1［J］.J Physiol Biochem,2019,75(3):379-389.
［23］YAN J,HUANG X,ZHANG X,et al.LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells［J］.Biochem Biophys Res Commun,2020,521(4):887-893.
［24］CHEN J,SUN Y,XU X,et al.YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells［J］.Cell Cycle,2017,16(23):2259-2271.
［25］TANG X,LIU S,CHEN D,et al.The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells［J］.Oncol Lett,2019,17(2):2473-2478.
［26］WANG W,WEI C.Advances in the early diagnosis of hepatocellular carcinoma［J］.Genes Dis,2020,7(3):308-319.
［27］YU ZL,ZHU ZM.Comprehensive analysis of N6-methyladenosine-related long non-coding RNAs and immune cell infiltration in hepatocellular carcinoma［J］.Bioengineered,2021,12(1):1708-1724.
［28］QI LW,JIA JH,JIANG CH,et al.Contributions and prognostic values of N6-methyladenosine RNA methylation regulators in hepatocellular carcinoma［J］.Front Genet,2020,11:614566.
［29］NAKAGAWA N,TANAKA K,SONOHARA F,et al.Novel prognostic implications of methylated RNA and demethylases in resected HCC and background liver tissue［J］.Anticancer Res,2020,40(12):6665-6676.
［30］LIN Z,NIU Y,WAN A,et al.RNA m6A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy［J］.Embo J,2020,39(12):e103181.
［31］ZUO X,CHEN Z,GAO W,et al.m6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma［J］.J Hematol Oncol,2020,13(1):5.
［32］HOU PP,LUO LJ,CHEN HZ,et al.Ectosomal PKM2 promotes HCC by inducing macrophage differentiation and remodeling the tumor microenvironment［J］.Mol Cell,2020,78(6):1192-1206.
［33］LI TE,WANG S,SHEN XT,et al.PKM2 drives hepatocellular carcinoma progression by inducing immunosuppressive microenvironment［J］.Front Immunol,2020,11:589997.
［34］LI J,ZHU L,SHI Y,et al.m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation［J］.Am J Transl Res,2019,11(9):6084-6092.
［35］JI L,CHEN S,GU L,et al.Exploration of potential roles of m6A regulators in colorectal cancer prognosis［J］.Front Oncol,2020,10:768.
［36］XU D,SHAO J,SONG H,et al.The YTH domain family of N6-methyladenosine "readers" in the diagnosis and prognosis of colonic adenocarcinoma［J］.Biomed Res Int,2020,2020:9502560.
［37］GRIMM D,BAUER J,WISE P,et al.The role of SOX family members in solid tumours and metastasis［J］.Semin Cancer Biol,2020,67(Pt 1):122-153.
［38］LI T,HU PS,ZUO Z,et al.METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma［J］.Mol Cancer,2019,18(1):112.
［39］XU J,CHEN Q,TIAN K,et al.m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation［J］.Oncol Rep,2020,44(3):973-986.
［40］PENG W,LI J,CHEN R,et al.Upregulated METTL3 promotes metastasis of colorectal cancer via miR-1246/SPRED2/MAPK signaling pathway［J］.J Exp Clin Cancer Res,2019,38(1):393.
［41］YANG X,ZHANG S,HE C,et al.METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST［J］.Mol Cancer,2020,19(1):46.
［42］CHEN X,XU M,XU X,et al.METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer［J］.Mol Cancer,2020,19(1):106.
［43］CHEN X,XU M,XU X,et al.METTL14 suppresses CRC progression via regulating N6-methyladenosine-dependent primary miR-375 processing［J］.Mol Ther,2020,28(2):599-612.
［44］YANG P,WANG Q,LIU A,et al.ALKBH5 holds prognostic values and inhibits the metastasis of colon cancer［J］.Pathol Oncol Res,2020,26(3):1615-1623.
［45］NI W,YAO S,ZHOU Y,et al.Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3［J］.Mol Cancer,2019,18(1):143.
［46］BAI Y,YANG C,WU R,et al.YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma［J］.Front Oncol,2019,9:332.
［47］WU Y,YANG X,CHEN Z,et al.m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1［J］.Mol Cancer,2019,18(1):87.
［48］YANG Z,WANG T,WU D,et al.RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer［J］.J Exp Clin Cancer Res,2020,39(1):203.
［49］XU Y,LIU J,CHEN WJ,et al.Regulation of N6-methyladenosine in the differentiation of cancer stem cells and their fate［J］.Front Cell Dev Biol,2020,8:561703.