|Table of Contents|

Research progress of tumor infiltrating lymphocytes and long non-coding RNA in tumor development

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 06
Page:
1097-1102
Research Field:
Publishing date:

Info

Title:
Research progress of tumor infiltrating lymphocytes and long non-coding RNA in tumor development
Author(s):
YANG Peipei1; 2; CHANG Lisha1; 2; ZHU Jing1; 2; WANG Keming1; 2
1.Nanjing Medical University,Jiangsu Nanjing 210011,China;2.The Second Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210011,China.
Keywords:
long non-coding RNA(lncRNA); tumor infiltrating lymphocytes; T lymphocytes; B lymphocytes; nature killer cells
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2022.06.031
Abstract:
Tumor infiltrating lymphocytes(TILs) exert a vital effect on the tumor microenvironment,and different cell subsets play anti-tumor or pro-tumor roles during tumor progression.TILs mainly include T lymphocytes,B lymphocytes and natural killer cells.These cells can mature,differentiate and take effect under the stimulation of various factors,which participate in the tumor immune response.Long non-coding RNA(lncRNA) is a group of pleiotropic regulators,which is associated with a variety of physiological and pathological processes.LncRNA can mediate the maturation and differentiation of TILs through regulating the release of cytokines and participate in relevant immunomodulatory signaling processes to regulate tumor immune function.Therefore,the correlation between aberrant expressed lncRNA and TILs might serve as a potential target of tumor diagnosis and treatment.

References:

［1］ALTORKI NK,MARKOWITZ GJ,GAO D,et al.The lung microenvironment:an important regulator of tumour growth and metastasis［J］.Nat Rev Cancer,2019,19(1):9-31.
［2］IAMS WT,SHIUAN E,MEADOR CB,et al.Improved prognosis and increased tumor-infiltrating lymphocytes in patients who have SCLC with neurologic paraneoplastic syndromes［J］.J Thorac Oncol,2019,14(11):1970-1981.
［3］ROSENBERG SA,SPIESS P,LAFRENIERE R.A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes［J］.Science,1986,233(4770):1318-1321.
［4］ROSENBERG SA,PACKARD BS,AEBERSOLD PM,et al.Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma.A preliminary report［J］.N Engl J Med,1988,319(25):1676-1680.
［5］LIN B,DU LK,LI H,et al.Tumor-infiltrating lymphocytes:Warriors fight against tumors powerfully［J］.Biomed Pharmacother,2020,132:110873.
［6］TOSS MS,MILIGY I,AL-KAWAZ A,et al.Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast［J］.Mod Pathol,2018,31(8):1226-1236.
［7］OBERG HH,JANITSCHKE L,SULAJ V,et al.Bispecific antibodies enhance tumor-infiltrating T cell cytotoxicity against autologous HER-2-expressing high-grade ovarian tumors［J］.J Leukoc Biol,2020,107(6):1081-1095.
［8］ZHOU M,ZHANG Z,BAO S,et al.Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer［J］.Brief Bioinform,2021,22(3):bbaa047.
［9］STANTON SE,ADAMS S,DISIS ML.Variation in the incidence and magnitude of tumor-infiltrating lymphocytes in breast cancer subtypes:a systematic review［J］.JAMA Oncol,2016,2(10):1354-1360.
［10］陈文雅,容少玲,钟振国.肿瘤浸润性淋巴细胞在肿瘤免疫中的作用研究进展［J］.广西中医药,2020,43(05):66-68. CHEN WY,RONG SL,ZHONG ZG.Research progress on the role of tumor infiltrating lymphocytes in tumor immunity［J］.Guangxi Journal of Traditional Chinese Medicine,2020,43(05):66-68.
［11］JANSEN CS,PROKHNEVSKA N,MASTER VA,et al.An intra-tumoral niche maintains and differentiates stem-like CD8 T cells［J］.Nature,2019,576(7787):465-470.
［12］STATELLO L,GUO CJ,CHEN LL,et al.Gene regulation by long non-coding RNAs and its biological functions［J］.Nat Rev Mol Cell Biol,2021,22(2):96-118.
［13］STACKHOUSE CT,GILLESPIE GY,WILLEY CD.Exploring the roles of lncRNAs in GBM pathophysiology and their therapeutic potential［J］.Cells,2020,9(11):2369.
［14］JARROUX J,FORETEK D,BERTRAND C,et al.HOTAIR lncRNA promotes epithelial-mesenchymal transition by redistributing LSD1 at regulatory chromatin regions［J］.EMBO Rep,2021,22(7):e50193.
［15］WANG M,DAI M,WANG D,et al.The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway［J］.Cancer Lett,2021,512:60-72.
［16］WANG H,MA P,LIU P,et al.lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization［J］.Cancer Lett,2021,520:121-131.
［17］KONG D,HOU Y,LI W,et al.LncRNA-ZXF1 regulates P21 expression in endometrioid endometrial carcinoma by managing ubiquitination-mediated degradation and miR-378a-3p/PCDHA3 axis［J/OL］.Mol Oncol,2021［2021-03-09］.https://doi.org/10.1002/1878-0261.12940.
［18］BRIDGES MC,DAULAGALA AC,KOURTIDIS A.LNCcation:lncRNA localization and function［J］.J Cell Biol,2021,220(2):e202009045.
［19］WANG H,SHI Y,CHEN CH,et al.KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast cancer cell growth and survival by upregulating the expression of IGFL1［J］.Cancer Lett,2021,515:49-62.
［20］PANDYA-JONES A,BLACK DL.Co-transcriptional splicing of constitutive and alternative exons［J］.RNA,2009,15(10):1896-1908.
［21］CHEN YG,SATPATHY AT,CHANG HY.Gene regulation in the immune system by long noncoding RNAs［J］.Nat Immunol,2017,18(9):962-972.
［22］CHANG L,LI J,DING J,et al.Roles of long noncoding RNAs on tumor immune escape by regulating immune cells differentiation and function［J］.Am J Cancer Res,2021,11(6):2369-2385.
［23］SUN J,ZHANG Z,BAO S,et al.Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer［J］.J Immunother Cancer,2020,8(1):e000110.
［24］YONEDA K,KUWATA T,KANAYAMA M,et al.Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer［J］.Br J Cancer,2019,121(6):490-496.
［25］WANG X,ZHANG Y,ZHENG J,et al.LncRNA UCA1 attenuated the killing effect of cytotoxic CD8+ T cells on anaplastic thyroid carcinoma via miR-148a/PD-L1 pathway［J］.Cancer Immunol Immunother,2021,70(6):unknown.
［26］KUMAR BV,CONNORS TJ,FARBER DL.Human T cell development,localization,and function throughout life［J］.Immunity,2018,48(2):202-213.
［27］WANG J,HUANG F,SHI Y,et al.RP11-323N12.5 promotes the malignancy and immunosuppression of human gastric cancer by increasing YAP1 transcription［J］.Gastric Cancer,2021,24(1):85-102.
［28］宋运来,朱月伊,周诣,等.IFN-γ与肿瘤免疫［J］.现代肿瘤医学,2021,29(01):143-148. SONG YL,ZHU YY,ZHOU Y,et al.IFN-γ and tumor immunity［J］.Modern Oncology,2021,29(01):143-148.
［29］钟明,王丁丁.自然杀伤细胞的生物学特性和肿瘤免疫治疗研究概述［J］.生物学教学,2021,46(8):2-4. ZHONG M,WANG DD.An overview of the biological characteristics of natural killer cells and tumor immunotherapy［J］.Biology,Teaching,2021,46(8):2-4.
［30］QIN X,ZHOU M,LYV H,et al.Long noncoding RNA LINC00657 inhibits cervical cancer development by sponging miR-20a-5p and targeting RUNX3［J］.Cancer Lett,2021,498:130-141.
［31］BERAZA N,MALATO Y,SANDER LE,et al.Hepatocyte-specific NEMO deletion promotes NK/NKT cell-and TRAIL-dependent liver damage［J］.J Exp Med,2009,206(8):1727-1737.
［32］ZHANG Y,LI X,ZHANG J,et al.Natural killer T cell cytotoxic activity in cervical cancer is facilitated by the LINC00240/microRNA-124-3p/STAT3/MICA axis［J］.Cancer Lett,2020,474:63-73.
［33］BEDEL R,THIERY-VUILLEMIN A,GRANDCLEMENT C,et al.Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells［J］.Cancer Res,2011,71(5):1615-1626.
［34］YAN K,FU Y,ZHU N,et al.Repression of lncRNA NEAT1 enhances the antitumor activity of CD8(+)T cells against hepatocellular carcinoma via regulating miR-155/Tim-3［J］.Int J Biochem Cell Biol,2019,110:1-8.
［35］KANG CW,DUTTA A,CHANG LY,et al.Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer［J］.Sci Rep,2015,5:15659.
［36］JI J,YIN Y,JU H,et al.Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC［J］.Cell Death Dis,2018,9(5):478.
［37］PEI X,WANG X,LI H.LncRNA SNHG1 regulates the differentiation of Treg cells and affects the immune escape of breast cancer via regulating miR-448/IDO［J］.Int J Biol Macromol,2018,118(Pt A):24-30.
［38］SUN J,YU J,LI H,et al.Upregulated expression of indoleamine 2,3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells［J］.J Exp Clin Cancer Res,2011,30:82.
［39］WEI MF,GU ZS,ZHENG LL,et al.Long non-coding RNA GAS5 promotes natural killer cell cytotoxicity against gastric cancer by regulating miR-18a［J］.Neoplasma,2020,67(5):1085-1093.
［40］FANG P,XIANG L,CHEN W,et al.LncRNA GAS5 enhanced the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3［J］.Innate Immun,2019,25(2):99-109.
［41］LI Y,SONG S,PIZZI MP,et al.LncRNA PVT1 is a poor prognosticator and can be targeted by PVT1 antisense oligos in gastric adenocarcinoma［J］.Cancers(Basel),2020,12(10):2995.
［42］LI M,DING X,ZHANG Y,et al.Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/beta-catenin pathway in head and neck squamous cell carcinomas［J］.Cell Death Dis,2020,11(8):672.
［43］CHEN BW,ZHOU Y,WEI T,et al.lncRNA-POIR promotes epithelial-mesenchymal transition and suppresses sorafenib sensitivity simultaneously in hepatocellular carcinoma by sponging miR-182-5p［J］.J Cell Biochem,2021,122(1):130-142.
［44］HAO Q,WANG P,DUTTA P,et al.Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4,a novel oncogenic long noncoding RNA［J］.Cell Death Dis,2020,11(12):1052.
［45］LUCERE KM,O'MALLEY M,DIERMEIER SD.Functional screening techniques to identify long non-coding RNAs as therapeutic targets in cancer［J］.Cancers(Basel),2020,12(12):3695.
［46］LIU Y,CAO Z,WANG Y,et al.Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites［J］.Nat Biotechnol,2018,36:1203-1210.
［47］XU P,LUO H,KONG Y,et al.Cancer neoantigen:Boosting immunotherapy［J］.Biomed Pharmacother,2020,131:110640.
［48］QU L,DING J,CHEN C,et al.Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA［J］.Cancer Cell,2016,29(5):653-668.
［49］PENG L,CHEN Y,OU Q,et al.LncRNA MIAT correlates with immune infiltrates and drug reactions in hepatocellular carcinoma［J］.Int Immunopharmacol,2020,89(Pt A):107071.

Memo

Memo:
National Natural Science Foundation of China(No.81972278，81772603）；国家自然科学基金面上项目（编号：81972278，81772603）
Last Update: 1900-01-01