|Table of Contents|

A clinicopathological analysis of high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix(5 cases)

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 06
Page:
1065-1068
Research Field:
Publishing date:

Info

Title:
A clinicopathological analysis of high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix(5 cases)
Author(s):
PANG Chunguang1; DENG Wei2; HUANG Renpeng3
1.Department of Pathology,the Third People's Hospital of Kunshan,Jiangsu Suzhou 215300,China;2.Department of Pathology,Traditional Chinese Medicine Hospital of Kunshan Affiliated to Nanjing University of Traditional Chinese Medicine,Jiangsu Suzhou 215300,China;3.Department of Pathology,the First Affiliated Hospital of Soochow University,Jiangsu Suzhou 215000,China.
Keywords:
high-grade squamous intraepithelial lesion; adenocarcinoma in situ; HPV16/18
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2022.06.023
Abstract:
Objective:To study the clinicopathological features,diagnosis and differential diagnosis of high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix.Methods:Five patients with high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix were reviewed retrospectively.Related domestic and foreign literatures were analyzed and discussed.Results:High-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix occurred among middle-aged women.High-grade squamous intraepithelial lesion and adenocarcinoma in situ had different histopathology.They were independent lesion.The results showed that both high-grade squamous intraepithelial lesion and adenocarcinoma in situ had diffuse nuclear and cytoplasmic immunohistochemical staining with p16.Both high-grade squamous intraepithelial lesion and adenocarcinoma in situ had increased Ki-67 expression.Adenocarcinoma in situ showed cytoplasmic positivity for CEA.Three cases performed HPV detection in five patients.One case was positive for HPV16.Two cases were positive for HPV18.Conclusion:Because of the coexistence of two lesions,high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix is easy to be misdiagnosed.HPV16 and HPV18 demonstrate the carcinogenic potency in high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix.

References:

[1] SAKAMOTO J,KAMIURA S,OKAYAMA K,et al.Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan［J］.Papillomavirus Res,2018,6:46-51.
[2] COHEN PA,BRAND A,SYKES P,et al.Excisional treatment in women with cervical adenocarcinoma in situ (AIS):a prospective randomised controlled non-inferiority trial to compare AIS persistence/recurrence after loop electrosurgical excision procedure with cold knife cone biopsy:protocol for a pilot study［J］.BMJ Open,2017,7(8):e017576.
[3] CASTELLSAGU X,DAZ M,DE SANJOS S ,et al.Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors:implications for screening and prevention［J］.J Natl Cancer Inst,2006,98(5):303-315.
[4] FINDIK S,ABUOGLU S,CIHAN FG,et al.Human papillomavirus (HPV) subtypes and their relationships with cervical smear results in cervical cancer screening:a community-based study from the central Anatolia region of Turkey［J］.Int J Clin Exp Pathol,2019,12(4):1391-1398.
[5] 康红，叶延程，樊平，等.HPV联合TCT检测在宫颈癌筛查中的应用［J］.现代肿瘤医学，2020,28（02）：283-286. KANG Hong,YE Yancheng,FAN Ping,et al.The application of HPV combined TCT testing in cervical cancer screening［J］.Modern Oncology,2020,28（02）：283-286.
[6] SRISOMBOON S,TANTIPALAKORN C,CHAROENKWAN K,et al.Cervical screening results leading to detection of adenocarcinoma in situ of the uterine cervix［J］.Asian Pac J Cancer Prev,2019,20(2):377-382.
[7] KURMAN RJ,CARCANGIU ML,HERRINGTON CS,et al.WHO classification of tumours of female reproduction organs［M］.4th ed.Lyon:International Agency for Research on Cancer,2014:183-184.
[8] GADDUCCI A,GUERRIERI ME,COSIO S.Adenocarcinoma of the uterine cervix:Pathologic features,treatment options,clinical outcome and prognostic variables［J］.Crit Rev Oncol Hematol,2019,135:103-114.
[9] IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.Human papillomaviruses［J］.IARC Monogr Eval Carcinog Risks Hum,1995,64:1-378.
[10] 张勤,王冬.高危型HPV感染在宫颈癌前病变、宫颈癌中的临床意义［J］.现代肿瘤医学，2020,28(05):788-791. ZHANG Qin,WANG Dong.Clinical significance of high-risk HPV testing for cervical precancerous lesions and cervical cancer［J］.Modern Oncology，2020,28(05):788-791.
[11] 周琴， 钱文艳， 朱艳，等.1081例患者宫颈HR-HPV感染情况分析［J］.现代肿瘤医学，2018,26（06）：917-919. ZHOU Qin,QIAN Wenyan,ZHU Yan,et al.The investigation of high-risk human papillomavirus infection in cervix of 1081 women［J］.Modern Oncology，2018,26（06）：917-919.
[12] SMITH JS,LINDSAY L,HOOT B,et al.Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update［J］.Int J Cancer,2007,121(3):621-632.
[13] CODDE E,MUNRO A,STEWART C,et al.Risk of persistent or recurrent cervical neoplasia in patients with 'pure' adenocarcinoma-in-situ (AIS) or mixed AIS and high-grade cervical squamous neoplasia (cervical intra-epithelial neoplasia grades 2 and 3 (CIN 2/3)):a population-based study［J］.Bjog,2018,125(1):74-79.
[14] OSTR AG,PAGANO R,DAVOREN RA,et al.Adenocarcinoma in situ of the cervix［J］.Int J Gynecol Pathol,1984,3(2):179-190.
[15]贾帅,王晓晶,张欣荣,等.宫颈原位腺癌的临床病理分析［J］.诊断病理学杂志,2019,26(2):125-127. JIA S,WANG XJ,ZHANG XR,et al.Adenocarcinoma in situ of the uterine cervix:a clinicopathological analysis［J］.Chinese Journal of Diagnostic Pathology,2019,26(2):125-127.
[16] LAX SF,HORN LC,LNING T.Categorization of uterine cervix tumors:What's new in the 2014 WHO classification［J］.Pathologe,2016,37(6):573-584.
[17] KAWAKAMI F,SEMBA S,ITAMI H,et al.Pathogenesis of combined high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix:human papillomavirus genotype and methylation status and immunohistochemical study［J］.Kobe J Med Sci,2014,60(3):E66-73.
[18] LEE KR,FLYNN CE.Early invasive adenocarcinoma of the cervix［J］.Cancer,2000,89(5):1048-1055.
[19] WHEELER DT,KURMAN RJ.The relationship of glands to thick-wall blood vessels as a marker of invasion in endocervical adenocarcinoma［J］.Int J Gynecol Pathol,2005,24(2):125-130.

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