|Table of Contents|

Clinicopathologic analysis of secretory carcinoma of the parotid gland (2 cases)

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 06
Page:
1006-1010
Research Field:
Publishing date:

Info

Title:
Clinicopathologic analysis of secretory carcinoma of the parotid gland (2 cases)
Author(s):
YANG Wensheng; LIN Zhen; LIU Xueqing
Department of Pathology,Army 73rd Group Military Hospital of the People's Liberation Army of China and Affiliated Chenggong Hospital of Xiamen University,Fujian Xiamen 361003,China.
Keywords:
secretory carcinoma; parotid gland; clinicopathological features
PACS:
R739.91
DOI:
10.3969/j.issn.1672-4992.2022.06.011
Abstract:
Objective:To investigate the molecular genetic characteristics,pathologic diagnosis,differential diagnosis,treatment and prognosis of secretory carcinoma (SC).Methods:Histomorphological analyse and immunohistochemical study were performed on 2 rare cases of SC of the parotid gland,and the relevant literatures were reviewed.Results:Two male patients with 37 and 45 years old respectively,were admitted to the hospital due to the painless and growing mass on the left face for several years and CT indicated the left parotid gland occupation.Microscopically,the tumor cell was small to medium in size,which possessed relatively uniform round to oval nuclei with small nucleoli and abundant eosinophilic granular cytoplasm.These tumor cells were arranged into solid,glandular tubular,microcystic/cribriform,and papilla-cystic structures,surrounded by fibrous septa,and contained colloid-like or mucinous secretions in some lacunas.Mitotic figures were occasionally seen.There was no necrosis.Immunohistochemistry showed that Mammaglobin,S-100 and SOX10 were diffusely and strongly expressed in tumor cells.CK7,CK18,CD117 and Vimentin were strongly expressed,and GATA3 was expressed to varying degrees.The expression of DOG1 was absent in most of the tumor cells,and was weakly positive only in a few of the surrounding of tumor nests or lumen margin,while CgA,Syn,p63,GCDFP-15,AR and HER-2 were negative.Ki-67 proliferation index was about 10%.Conclusion:In general,SC is a rare low-grade malignant tumor.Careful analysis of histological characteristics and immunohistochemical results is sufficient in most cases to produce a pathological diagnosis of SC without the necessity of molecular testing.

References:

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