[1]HAN J,WON M,KIM JH,et al.Cancer stem cell-targeted bio-imaging and chemotherapeutic perspective[J].Chem Soc Rev,2020,49(22):7856-7878.
[2]TIRINATO L,LIBERALE C,DI FRANCO S,et al.Lipid droplets:a new player in colorectal cancer stem cells unveiled by spectroscopic imaging[J].Stem Cells,2015,33(1):35-44.
[3]PETAN T,JARC E,JUSOVIC M.Lipid droplets in cancer:guardians of fat in a stressful world[J].Molecules,2018,23(8):1941.
[4]MARTIN S.Caveolae,lipid droplets,and adipose tissue biology:pathophysiological aspects[J].Horm Mol Biol Clin Investig,2013,15(1):11-18.
[5]WILFLING F,THIAM AR,OLARTE MJ,et al.Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting[J].Elife,2014,3:e01607.
[6]WANG G,XU J,ZHAO J,et al.Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice[J].Nat Commun,2020,11(1):220.
[7]CARRACEDO A,CANTLEY LC,PANDOLFI PP.Cancer metabolism:fatty acid oxidation in the limelight[J].Nat Rev Cancer,2013,13(4):227-232.
[8]PARK JH,VITHAYATHIL S,KUMAR S,et al.Fatty acid oxidation-driven src links mitochondrial energy reprogramming and oncogenic properties in triple-negative breast cancer[J].Cell Rep,2016,14(9):2154-2165.
[9]CHEN CL,UTHAYA KUMAR DB,PUNJ V,et al.NANOG metabolically reprograms tumor-initiating stem-like cells through tumorigenic changes in oxidative phosphorylation and fatty acid metabolism[J].Cell Metab,2016,23(1):206-219.
[10]LIU S,CHENG K,ZHANG H,et al.Methylation status of the nanog promoter determines the switch between cancer cells and cancer stem cells[J].Adv Sci(Weinh),2020,7(5):1903035.
[11]LO REO,DOUET J,BUSCHBECK M,et al.Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells[J].Epigenetics,2018,13(8):829-845.
[12]ZHANG C,YUE C,HERRMANN A,et al.STAT3 activation-induced fatty acid oxidation in CD8(+)T effector cells is critical for obesity-promoted breast tumor growth[J].Cell Metab,2020,31(1):148-161.
[13]LI W,ZHANG Q,CHEN K,et al.2-Ethoxystypandrone,a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum,inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells[J].BMC Complement Altern Med,2019,19:38.
[14]YASUMOTO Y,MIYAZAKI H,VAIDYAN LK,et al.Inhibition of fatty acid synthase decreases expression of stemness markers in glioma stem cells[J].PLoS One,2016,11(1):e0147717.
[15]LI J,CONDELLO S,THOMES-PEPIN J,et al.Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells[J].Cell Stem Cell,2017,20(3):303-314.
[16]SUN M,YANG Z.Metabolomic studies of live single cancer stem cells using mass spectrometry[J].Anal Chem,2019,91(3):2384-2391.
[17]VISWESWARAN M,ARFUSO F,WARRIER S,et al.Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells[J].Stem Cells,2020,38(1):6-14.
[18]RIVAS SERNA IM,ROMITO I,MAUGERI A,et al.A Lipidomic signature complements stemness features acquisition in liver cancer cells[J].Int J Mol Sci,2020,21(22):8452.
[19]BORT A,SANCHEZ BG,DE MIGUEL I,et al.Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells[J].Mol Biol Rep,2020,47(4):2635-2647.
[20]LIN L,DING Y,WANG Y,et al.Functional lipidomics:Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism[J].Hepatology,2017,66(2):432-448.
[21]MULLEN PJ,YU R,LONGO J,et al.The interplay between cell signalling and the mevalonate pathway in cancer[J].Nat Rev Cancer,2016,16(11):718-731.
[22]MANCINI R,NOTO A,PISANU ME,et al.Metabolic features of cancer stem cells:the emerging role of lipid metabolism[J].Oncogene,2018,37(18):2367-2378.
[23]IANNELLI F,ROCA MS,LOMBARDI R,et al.Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition[J].J Exp Clin Cancer Res,2020,39:213.
[24]SHARON C,BARANWAL S,PATEL NJ,et al.Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo[J].Oncotarget,2015,6(17):15332-15347.
[25]BRANDI J,DANDO I,POZZA ED,et al.Proteomic analysis of pancreatic cancer stem cells:Functional role of fatty acid synthesis and mevalonate pathways[J].J Proteomics,2017,150:310-322.
[26]SEO Y,KIM J,PARK SJ,et al.Metformin suppresses cancer stem cells through ampk activation and inhibition of protein prenylation of the mevalonate pathway in colorectal cancer[J].Cancers(Basel),2020,12(9):2554.
[27]EHMSEN S,PEDERSEN MH,WANG G,et al.Increased cholesterol biosynthesis is a key characteristic of breast cancer stem cells influencing patient outcome[J].Cell Rep,2019,27(13):3927-3938.
[28]LIANG Y,GOYETTE S,HYDER SM.Cholesterol biosynthesis inhibitor RO 48-8071 reduces progesterone receptor expression and inhibits progestin-dependent stem cell-like cell growth in hormone-dependent human breast cancer cells[J].Breast Cancer(Dove Med Press),2017,9:487-494.
[29]KHAWAR MB,GAO H,LI W.Autophagy and lipid metabolism[J].Adv Exp Med Biol,2019,1206:359-374.
[30]BU H,LIU D,ZHANG G,et al.AMPK/mTOR/ULK1 axis-mediated pathway participates in apoptosis and autophagy induction by oridonin in colon cancer DLD-1 cells[J].Onco Targets Ther,2020,13:8533-8545.
[31]XIE Y,LI J,KANG R,et al.Interplay between lipid metabolism and autophagy[J].Front Cell Dev Biol,2020,8:431.
[32]PANNUTI A,FOREMAN K,RIZZO P,et al.Targeting notch to target cancer stem cells[J].Clin Cancer Res,2010,16(12):3141-3152.
[33]GHANBARI-MOVAHED M,GHANBARI-MOVAHED Z,MOMTAZ S,et al.Unlocking the secrets of cancer stem cells with γ-secretase inhibitors:a novel anticancer strategy[J].Molecules,2021,26(4):972.
[34]AKIL A,GUTIERREZ-GARCIA AK,GUENTER R,et al.Notch signaling in vascular endothelial cells,angiogenesis,and tumor progression:an update and prospective[J].Front Cell Dev Biol,2021,9:642352.
[35]JIANG N,ZOU C,ZHU Y,et al.HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling[J].Theranostics,2020,10(6):2553-2570.
[36]LI Y,WANG Z,JIN J,et al.Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway[J].Biochem Biophys Res Commun,2020,523(4):947-953.
[37]DANDAWATE P,SUBRAMANIAM D,PANOVICH P,et al.Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway[J].Sci Rep,2020,10(1):1290.
[38]VILLANUEVA A,ALSINET C,YANGER K,et al.Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice[J].Gastroenterology,2012,143(6):1660-1669.
[39]LEE HY,HONG IS.Targeting liver cancer stem cells:an alternative therapeutic approach for liver cancer[J].Cancers(Basel),2020,12(10):2746.
[40]YU Y,KIM H,CHOI S,et al.Targeting a lipid desaturation enzyme,scd1,selectively eliminates colon cancer stem cells through the suppression of wnt and NOTCH signaling[J].Cells,2021,10(1):106.
[41]LI Y,XIAO Y,LIN HP,et al.In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis[J].Biomaterials,2019,188:160-172.
[42]LIU W,CHEN X,WU M,et al.Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/β-catenin signaling pathway[J].BMC Cardiovasc Disord,2020,20(1):120.
[43]DAI L,ZHAO X,MA L,et al.TNF-α activates PI3K/AKT pathway to promote proliferation of SW620(Lgr5+)colon cancer stem cells[J].Chinese Journal of Cellular and Molecular Immunology,2020,36(1):33-41.
[44]GE JC,WANG YX,CHEN ZB,et al.Integrin alpha 7 correlates with poor clinical outcomes,and it regulates cell proliferation,apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma[J].Cell Signal,2020,66:109465.
[45]WADHWA B,PADDAR M,KHAN S,et al.AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity[J].Oncotarget,2020,11(45):4178-4194.
[46]WANG W,HE S,ZHANG R,et al.ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with β-catenin[J].Biomed Pharmacother,2020,125:109940.
[47]CHOI HS,KIM SL,KIM JH,et al.The FDA-approved anti-asthma medicine ciclesonide inhibits lung cancer stem cells through hedgehog signaling-mediated SOX2 regulation[J].Int J Mol Sci,2020,21(3):1014.
[48]JENG KS,CHANG CF,LIN SS.Sonic hedgehog signaling in organogenesis,tumors,and tumor microenvironments[J].Int J Mol Sci,2020,21(3):758.