|Table of Contents|

Lipid metabolism characteristics of cancer stem cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 05
Page:
908-912
Research Field:
Publishing date:

Info

Title:
Lipid metabolism characteristics of cancer stem cells
Author(s):
ZHAO Longcheng1WU Fan12
1.Department of Hepatobiliary Surgery,Guangzhou Red Cross Hospital,Medical College of Jinan University,Guangdong Guangzhou 510220,China;2.Department of Hepatobiliary Surgery,Guangzhou Red Cross Hospital,Guangdong Guangzhou 510220,China.
Keywords:
cancer stem cells(CSCs)fatty acids(FA)cholesterolautophagy
PACS:
R730.23
DOI:
10.3969/j.issn.1672-4992.2022.05.032
Abstract:
Cancer stem cells(CSCs)are small group of heterogeneous cells in tumors that are capable of self-renewal and tumorigenesis.They are the underlying drivers of tumor genesis,metastasis,recurrence and drug resistance.At present,the study found CSCs stemness maintenance largely depends on its characteristic of lipid metabolic changes,they can through various means to maintain stemness and its microenvironment,such as:improve the intracellular content of fatty acid(FA)to supply energy,promote the FA β-oxidation to enhance energy efficiency,increase mevalonate pathway to improve synthesis of cholesterol,etc.In addition,lipid droplets(LDs)can provide alternative energy to protect FA from peroxidation when the glycolysis of CSCs is blocked.The interaction between autophagy and lipid metabolism enables CSCs to quickly adapt to the harsh microenvironment generated by chemotherapy.In this review,we reviewed recent studies on lipid metabolism of CSCs,and briefly introduced the necessity of LDs,FA,cholesterol metabolism and autophagy for stemness maintenance of CSCs.

References:

[1]HAN J,WON M,KIM JH,et al.Cancer stem cell-targeted bio-imaging and chemotherapeutic perspective[J].Chem Soc Rev,2020,49(22):7856-7878.
[2]TIRINATO L,LIBERALE C,DI FRANCO S,et al.Lipid droplets:a new player in colorectal cancer stem cells unveiled by spectroscopic imaging[J].Stem Cells,2015,33(1):35-44.
[3]PETAN T,JARC E,JUSOVIC M.Lipid droplets in cancer:guardians of fat in a stressful world[J].Molecules,2018,23(8):1941.
[4]MARTIN S.Caveolae,lipid droplets,and adipose tissue biology:pathophysiological aspects[J].Horm Mol Biol Clin Investig,2013,15(1):11-18.
[5]WILFLING F,THIAM AR,OLARTE MJ,et al.Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting[J].Elife,2014,3:e01607.
[6]WANG G,XU J,ZHAO J,et al.Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice[J].Nat Commun,2020,11(1):220.
[7]CARRACEDO A,CANTLEY LC,PANDOLFI PP.Cancer metabolism:fatty acid oxidation in the limelight[J].Nat Rev Cancer,2013,13(4):227-232.
[8]PARK JH,VITHAYATHIL S,KUMAR S,et al.Fatty acid oxidation-driven src links mitochondrial energy reprogramming and oncogenic properties in triple-negative breast cancer[J].Cell Rep,2016,14(9):2154-2165.
[9]CHEN CL,UTHAYA KUMAR DB,PUNJ V,et al.NANOG metabolically reprograms tumor-initiating stem-like cells through tumorigenic changes in oxidative phosphorylation and fatty acid metabolism[J].Cell Metab,2016,23(1):206-219.
[10]LIU S,CHENG K,ZHANG H,et al.Methylation status of the nanog promoter determines the switch between cancer cells and cancer stem cells[J].Adv Sci(Weinh),2020,7(5):1903035.
[11]LO REO,DOUET J,BUSCHBECK M,et al.Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells[J].Epigenetics,2018,13(8):829-845.
[12]ZHANG C,YUE C,HERRMANN A,et al.STAT3 activation-induced fatty acid oxidation in CD8(+)T effector cells is critical for obesity-promoted breast tumor growth[J].Cell Metab,2020,31(1):148-161.
[13]LI W,ZHANG Q,CHEN K,et al.2-Ethoxystypandrone,a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum,inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells[J].BMC Complement Altern Med,2019,19:38.
[14]YASUMOTO Y,MIYAZAKI H,VAIDYAN LK,et al.Inhibition of fatty acid synthase decreases expression of stemness markers in glioma stem cells[J].PLoS One,2016,11(1):e0147717.
[15]LI J,CONDELLO S,THOMES-PEPIN J,et al.Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells[J].Cell Stem Cell,2017,20(3):303-314.
[16]SUN M,YANG Z.Metabolomic studies of live single cancer stem cells using mass spectrometry[J].Anal Chem,2019,91(3):2384-2391.
[17]VISWESWARAN M,ARFUSO F,WARRIER S,et al.Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells[J].Stem Cells,2020,38(1):6-14.
[18]RIVAS SERNA IM,ROMITO I,MAUGERI A,et al.A Lipidomic signature complements stemness features acquisition in liver cancer cells[J].Int J Mol Sci,2020,21(22):8452.
[19]BORT A,SANCHEZ BG,DE MIGUEL I,et al.Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells[J].Mol Biol Rep,2020,47(4):2635-2647.
[20]LIN L,DING Y,WANG Y,et al.Functional lipidomics:Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism[J].Hepatology,2017,66(2):432-448.
[21]MULLEN PJ,YU R,LONGO J,et al.The interplay between cell signalling and the mevalonate pathway in cancer[J].Nat Rev Cancer,2016,16(11):718-731.
[22]MANCINI R,NOTO A,PISANU ME,et al.Metabolic features of cancer stem cells:the emerging role of lipid metabolism[J].Oncogene,2018,37(18):2367-2378.
[23]IANNELLI F,ROCA MS,LOMBARDI R,et al.Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition[J].J Exp Clin Cancer Res,2020,39:213.
[24]SHARON C,BARANWAL S,PATEL NJ,et al.Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo[J].Oncotarget,2015,6(17):15332-15347.
[25]BRANDI J,DANDO I,POZZA ED,et al.Proteomic analysis of pancreatic cancer stem cells:Functional role of fatty acid synthesis and mevalonate pathways[J].J Proteomics,2017,150:310-322.
[26]SEO Y,KIM J,PARK SJ,et al.Metformin suppresses cancer stem cells through ampk activation and inhibition of protein prenylation of the mevalonate pathway in colorectal cancer[J].Cancers(Basel),2020,12(9):2554.
[27]EHMSEN S,PEDERSEN MH,WANG G,et al.Increased cholesterol biosynthesis is a key characteristic of breast cancer stem cells influencing patient outcome[J].Cell Rep,2019,27(13):3927-3938.
[28]LIANG Y,GOYETTE S,HYDER SM.Cholesterol biosynthesis inhibitor RO 48-8071 reduces progesterone receptor expression and inhibits progestin-dependent stem cell-like cell growth in hormone-dependent human breast cancer cells[J].Breast Cancer(Dove Med Press),2017,9:487-494.
[29]KHAWAR MB,GAO H,LI W.Autophagy and lipid metabolism[J].Adv Exp Med Biol,2019,1206:359-374.
[30]BU H,LIU D,ZHANG G,et al.AMPK/mTOR/ULK1 axis-mediated pathway participates in apoptosis and autophagy induction by oridonin in colon cancer DLD-1 cells[J].Onco Targets Ther,2020,13:8533-8545.
[31]XIE Y,LI J,KANG R,et al.Interplay between lipid metabolism and autophagy[J].Front Cell Dev Biol,2020,8:431.
[32]PANNUTI A,FOREMAN K,RIZZO P,et al.Targeting notch to target cancer stem cells[J].Clin Cancer Res,2010,16(12):3141-3152.
[33]GHANBARI-MOVAHED M,GHANBARI-MOVAHED Z,MOMTAZ S,et al.Unlocking the secrets of cancer stem cells with γ-secretase inhibitors:a novel anticancer strategy[J].Molecules,2021,26(4):972.
[34]AKIL A,GUTIERREZ-GARCIA AK,GUENTER R,et al.Notch signaling in vascular endothelial cells,angiogenesis,and tumor progression:an update and prospective[J].Front Cell Dev Biol,2021,9:642352.
[35]JIANG N,ZOU C,ZHU Y,et al.HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling[J].Theranostics,2020,10(6):2553-2570.
[36]LI Y,WANG Z,JIN J,et al.Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway[J].Biochem Biophys Res Commun,2020,523(4):947-953.
[37]DANDAWATE P,SUBRAMANIAM D,PANOVICH P,et al.Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway[J].Sci Rep,2020,10(1):1290.
[38]VILLANUEVA A,ALSINET C,YANGER K,et al.Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice[J].Gastroenterology,2012,143(6):1660-1669.
[39]LEE HY,HONG IS.Targeting liver cancer stem cells:an alternative therapeutic approach for liver cancer[J].Cancers(Basel),2020,12(10):2746.
[40]YU Y,KIM H,CHOI S,et al.Targeting a lipid desaturation enzyme,scd1,selectively eliminates colon cancer stem cells through the suppression of wnt and NOTCH signaling[J].Cells,2021,10(1):106.
[41]LI Y,XIAO Y,LIN HP,et al.In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis[J].Biomaterials,2019,188:160-172.
[42]LIU W,CHEN X,WU M,et al.Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/β-catenin signaling pathway[J].BMC Cardiovasc Disord,2020,20(1):120.
[43]DAI L,ZHAO X,MA L,et al.TNF-α activates PI3K/AKT pathway to promote proliferation of SW620(Lgr5+)colon cancer stem cells[J].Chinese Journal of Cellular and Molecular Immunology,2020,36(1):33-41.
[44]GE JC,WANG YX,CHEN ZB,et al.Integrin alpha 7 correlates with poor clinical outcomes,and it regulates cell proliferation,apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma[J].Cell Signal,2020,66:109465.
[45]WADHWA B,PADDAR M,KHAN S,et al.AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity[J].Oncotarget,2020,11(45):4178-4194.
[46]WANG W,HE S,ZHANG R,et al.ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with β-catenin[J].Biomed Pharmacother,2020,125:109940.
[47]CHOI HS,KIM SL,KIM JH,et al.The FDA-approved anti-asthma medicine ciclesonide inhibits lung cancer stem cells through hedgehog signaling-mediated SOX2 regulation[J].Int J Mol Sci,2020,21(3):1014.
[48]JENG KS,CHANG CF,LIN SS.Sonic hedgehog signaling in organogenesis,tumors,and tumor microenvironments[J].Int J Mol Sci,2020,21(3):758.

Memo

Memo:
National Natural Science Foundation of China(No.81974442);国家自然科学基金(编号:81974442);广东省自然科学基金(编号:2020A1515010799)
Last Update: 2022-01-27