|Table of Contents|

The expression of A2aR in rectal cancer tissues and its relationship with neoadjuvant chemoradiotherapy sensitivity

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 05
Page:
848-851
Research Field:
Publishing date:

Info

Title:
The expression of A2aR in rectal cancer tissues and its relationship with neoadjuvant chemoradiotherapy sensitivity
Author(s):
YANG Song; SHI Linsen; JIANG Aijun; SUN Jian; ZHAO Benhuo; LIU Guihong
Center of Clinical Oncology,Affiliated Hospital of Xuzhou Medical University,Jiangsu Xuzhou 221002,China.
Keywords:
rectal carcinoma; A2aR; neoadjuvant therapy; pathologic complete response
PACS:
R735.2+7
DOI:
10.3969/j.issn.1672-4992.2022.05.019
Abstract:
Objective:To investigate the expression of adenosine 2a receptor(A2aR) in rectal cancer tissues and its relationship with neoadjuvant chemoradiotherapy sensitivity.Methods:A total of 56 patients with rectal cancer underwent paraffin biopsy before neoadjuvant chemoradiotherapy in our hospital from Jun 2014 to Jun 2019,and the expression of A2aR protein was detected by immunohistochemical staining.The rectal cancer regression grading standard was used to evaluate the sensitivity of rectal cancer tissue to radiotherapy and chemotherapy.Results:The positive expression rate of A2aR in rectal cancer tissues was 57.14%,and its expression was related to the TNM stage,differentiation grade,diameter and stage T,but not related to the age,gender and lymph node metastasis.Among all the patients,31 patients(55.36%) were sensitive to neoadjuvant chemoradiotherapy(RCRG 1-2),and 25 patients(RCRG 3) were insensitive(44.64%).The sensitivity of chemoradiotherapy in rectal cancer was related to the TNM stage,T stage,lymph node metastasis,tumor diameter,differentiation degree and the expression of A2aR,but not related to age and gender.A2aR expression was positively correlated with chemoradiotherapy sensitivity in rectal cancer(rs=0.531，P＜0.001).Multivariate regression analysis showed that A2aR expression(P=0.004) and T stage(P=0.02) were two independent factors affecting chemoradiotherapy sensitivity in rectal cancer.Conclusion:A2aR has a high positive expression rate in rectal cancer tissues and is correlated with neoadjuvant chemoradiotherapy sensitivity.

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Memo

Memo:
江苏省自然科学基金（编号：BK20151149）；江苏省卫健委面上项目（编号：H2019047）；江苏省徐州市医学重点研发项目（新型临床技术诊疗技术攻关）（编号：KC14SH118）；江苏省徐州市临床技术骨干研究计划（编号：2018GG031）
Last Update: 2022-01-27