|Table of Contents|

Research progress of circRNA in cancers

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 02
Page:
346-351
Research Field:
Publishing date:

Info

Title:
Research progress of circRNA in cancers
Author(s):
CHEN Yanhao12ZHANG Yanling1
1.School of Biotechnology and Laborotary Medicine,Southern Medical University,Guangdong Guangzhou 510515,China;2.Zhongshan School of Medicine,Sun Yat-sen University,Guangdong Guangzhou 515275,China.
Keywords:
circRNAtumornoncoding RNA
PACS:
R730.54
DOI:
10.3969/j.issn.1672-4992.2022.02.037
Abstract:
Circular RNA (circRNA) is a type of covalently closed RNA without 5'-3' terminal.It could be a tumor promoter or tumor suppressor in cancer and play a significant biological role through miRNA sponge,binding with RNA-binding protein,protein scaffolding,regulation to transcription and translation to proteins.circRNA participates in the tumorigenesis and development of cancers by circRNA-miRNA-mRNA axes.circRNA could be a potential biomarker for cancer diagnosis and prognosis,so it has become the focus of research followed miRNA and long noncoding RNA (lncRNA).

References:

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Memo:
广东省自然科学基金(编号:2017A030313447)
Last Update: 1900-01-01