|Table of Contents|

Research progress on the mechanism of acquired multidrug resistance in nasopharyngeal carcinoma and reversal effect of traditional Chinese medicine

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 02
Page:
333-337
Research Field:
Publishing date:

Info

Title:
Research progress on the mechanism of acquired multidrug resistance in nasopharyngeal carcinoma and reversal effect of traditional Chinese medicine
Author(s):
HE Ruiyuan1; GONG Xiaomei2; OU Chunli2; ZHANG Wenyu3; ZHOU Xiaolei2; MIAO Jianhua2; WANG Shuo2
1.Guangxi University of Chinese Medicine,Guangxi Nanning 530200,China;2.Institute of Guangxi Medicinal Plant,Guangxi Nanning 530023,China;3Affiliated Tumor Hospital of Guangxi Medical University,Guangxi Nanning 530021,China.
Keywords:
nasopharyngeal carcinoma; multidrug resistance; traditional Chinese medicine; reversing
PACS:
R739.63
DOI:
10.3969/j.issn.1672-4992.2022.02.034
Abstract:
Multidrug resistance (MDR)is the main cause of chemotherapy failure in locally advanced nasopharyngeal carcinoma.The occurrence and development of MDR in nasopharyngeal carcinoma is a complex process involving multiple factors and pathways,but its mechanism is still unclear.Therefore,elucidating the molecular mechanism of MDR in nasopharyngeal carcinoma is conducive to finding sensitive targets for drug resistance,so as to improve the therapeutic effect.In recent years,the active components in traditional Chinese medicine as natural tumor MDR reversal agents have been the focus of research.In this paper,we discussed the molecular mechanism of MDR in nasopharyngeal carcinoma from the aspects of drug efflux,cell apoptosis,DNA damage repair,autophagy and EMT,detoxification enzyme activity,pyroptosis and tumor microenvironment,and reviewed the research progress of MDR reversal in nasopharyngeal carcinoma by the active components in traditional Chinese medicine.

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Memo

Memo:
National Natural Science Foundation of China(No.81473309）;国家自然科学基金面上项目(编号：81473309)；广西自然科学基金面上项目(编号：2020GXNSFAA259008)
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