|Table of Contents|

Research progress of new drugs developed by DNA damage repair pathway and their application in the treatment of urogenital neoplasms

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 02
Page:
322-325
Research Field:
Publishing date:

Info

Title:
Research progress of new drugs developed by DNA damage repair pathway and their application in the treatment of urogenital neoplasms
Author(s):
LI Xiuming12ZENG Yu2
1.Department of Urology,the Affiliated Hospital of Chengde Medical University,Hebei Chengde 067000,China;2.Department of Urology,Liaoning Cancer Hospital and Institute,Liaoning Shenyang 110042,China.
Keywords:
DNA damage repairDNA damage responseurogenital neoplasmsanti-tumor effect
PACS:
R737
DOI:
10.3969/j.issn.1672-4992.2022.02.031
Abstract:
Genomic instability is an important feature of cancer and is caused by defective response to DNA damage or increased replication pressure.These defects can also become weaknesses of cancer cells that can be exploited to improve the effectiveness of anti-tumor treatments.In recent years,targeted drugs for DNA damage repair pathways have been developed rapidly,and anti-tumor activity and drug safety have been observed.Clinicians should be aware of the potential anti-tumor mechanisms of such drugs,including pharmacological similarities and differences,as well as the clinical results and side effects reported to date,in order to provide patients with optimal treatment options.Here,we summarize the current status of new drugs developed by DNA damage repair pathway and treatment of urogenital neoplasms.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.81572532);国家自然科学基金资助项目(编号:81572532);辽宁省高等学校攀登学者优才计划
Last Update: 1900-01-01